Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells

Audiology and Neurotology

Volumn 14, Issue 4, 2009, Pages 254-266

  Pfannenstiel, Susanna C ^a   Praetorius, Mark ^c   Plinkert, Peter K ^a   Brough, Douglas E ^b   Staecker, Hinrich ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b GENVEC INC   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adenovector; Aminoglycosides; Bcl 2 gene therapy; Gentamicin; Mice; Ototoxicity; Outer hair cells; Vestibulotoxicity

Indexed keywords

ADENOVIRUS VECTOR; GENTAMICIN; MYOSIN VIIA; PROTEIN BCL 2; ANTIINFECTIVE AGENT; MYOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; CELL DEGENERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; ELECTROCOCHLEOGRAPHY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; HAIR CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROPHYLAXIS; VESTIBULAR SYSTEM; VESTIBULE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; ADENOVIRUS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; GENE THERAPY; GENETICS; HEARING DISORDER; METABOLISM; METHODOLOGY; NICK END LABELING; PATHOLOGY;

ADENOVIRIDAE; ANIMALS; ANTI-BACTERIAL AGENTS; AUDITORY THRESHOLD; CELL SURVIVAL; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; GENE THERAPY; GENTAMICINS; HAIR CELLS, AUDITORY, OUTER; HAIR CELLS, VESTIBULAR; HEARING DISORDERS; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MYOSINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 58249083298     PISSN: 14203030     EISSN: 14219700     Source Type: Journal    
DOI: 10.1159/000192953     Document Type: Article

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