PPAR ligands decrease human airway smooth muscle cell migration and extracellular matrix synthesis

European Respiratory Journal

Volumn 41, Issue 2, 2013, Pages 425-432

  Stephen, Jancy ^a   Delvecchio, Chris ^a   Spitale, Naomi ^a   Giesler, Amanda ^a   Radford, Katherine ^a   Bilan, Pat ^a   Cox, P Gerard ^a   Capone, John P ^b   Nair, Parameswaran ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Airway smooth muscle migration; Asthma; Extracellular matrix; Peroxisome proliferator activated receptor; Prostaglandin E2

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; CIGLITAZONE; COLLAGEN; CYCLIC AMP; CYCLOOXYGENASE 2; FIBRONECTIN; LUCIFERASE; MESSENGER RNA; MK 866; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIRINIXIC ACID; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROSTAGLANDIN E2; PROTEIN KINASE B; SULINDAC; TROGLITAZONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BREATHING MUSCLE; CELL MIGRATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; EXTRACELLULAR MATRIX; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MIGRATION INHIBITION; PLASMID; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ADULT; AGED; CELL MOVEMENT; CELLS, CULTURED; DINOPROSTONE; EXTRACELLULAR MATRIX; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; MALE; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PHOSPHORIC MONOESTER HYDROLASES; SIGNAL TRANSDUCTION;

EID: 84873370810     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00145009     Document Type: Article

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