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Volumn 202, Issue 1, 2013, Pages 67-75

Comparison of HIV-1 viral load assay performance in immunological stable patients with low or undetectable viremia

Author keywords

Abbott; Blip; CD8+ CD38+; Low viral load; Real time PCR; Roche

Indexed keywords

NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

EID: 84873367194     PISSN: 03008584     EISSN: 14321831     Source Type: Journal    
DOI: 10.1007/s00430-012-0249-y     Document Type: Article
Times cited : (24)

References (51)
  • 2
    • 78449293783 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 group M quasispecies evolution: Diversity and divergence in patients co-infected with active tuberculosis
    • 20697741 10.1007/s00430-010-0167-9 1:CAS:528:DC%2BC3cXht12qtLfI
    • Biru T, Lennemann T, Stürmer M, Stephan C, Nisius G, Cinatl J, Staszewski S, Gürtler LG (2010) Human immunodeficiency virus type-1 group M quasispecies evolution: diversity and divergence in patients co-infected with active tuberculosis. Med Microbiol Immunol 199:323-332
    • (2010) Med Microbiol Immunol , vol.199 , pp. 323-332
    • Biru, T.1    Lennemann, T.2    Stürmer, M.3    Stephan, C.4    Nisius, G.5    Cinatl, J.6    Staszewski, S.7    Gürtler, L.G.8
  • 5
    • 83055179796 scopus 로고    scopus 로고
    • The SnoB study: Frequency of baseline raltegravir resistance mutations prevalence in different non-B subtypes
    • Sierra S, Lübke N, Walter H, Schülter E, Reuter S, Fätkenheuer G, Bickel M, da Silva H, Kaiser R, Esser S; SnoB-Study group 10.1007/s00430-011-0194-1
    • Sierra S, Lübke N, Walter H, Schülter E, Reuter S, Fätkenheuer G, Bickel M, da Silva H, Kaiser R, Esser S; SnoB-Study group (2011) The SnoB study: frequency of baseline raltegravir resistance mutations prevalence in different non-B subtypes. Med Microbiol Immunol 200:225-232
    • (2011) Med Microbiol Immunol , vol.200 , pp. 225-232
  • 7
    • 0030070991 scopus 로고    scopus 로고
    • Prognosis in HIV-1 infection predicted by the quantity of virus in plasma
    • 8638160 10.1126/science.272.5265.1167 1:CAS:528:DyaK28XjtF2nsrg%3D
    • Mellors J, Rinaldo C Jr, Gupta P, White R, Todd J, Kinglsey L (1996) Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272:1167-1170
    • (1996) Science , vol.272 , pp. 1167-1170
    • Mellors, J.1    Rinaldo, Jr.C.2    Gupta, P.3    White, R.4    Todd, J.5    Kinglsey, L.6
  • 8
    • 84855616052 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adults and Adolescents Department of Health and Human Services (Online) Accessed 14 Oct 2011
    • Panel on Antiretroviral Guidelines for Adults and Adolescents (2011) Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services (Online) http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed 14 Oct 2011
    • (2011) Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents
  • 11
    • 78751616765 scopus 로고    scopus 로고
    • The significance of very low-level viraemia detected by sensitive viral load assays in HIV infected patients on HAART
    • 21073896 10.1016/j.jinf.2010.11.001
    • Widdrington J, Payne B, Medhi M, Valappil M, Schmid ML (2011) The significance of very low-level viraemia detected by sensitive viral load assays in HIV infected patients on HAART. J Infect 62:87-92
    • (2011) J Infect , vol.62 , pp. 87-92
    • Widdrington, J.1    Payne, B.2    Medhi, M.3    Valappil, M.4    Schmid, M.L.5
  • 12
    • 33747689078 scopus 로고    scopus 로고
    • Persistent low-level viraemia and virological failure in HIV-1-infected patients treated with highly active antiretroviral therapy
    • 16925729 10.1111/j.1468-1293.2006.00403.x 1:CAS:528:DC%2BD28XhtVOqtLrM
    • Sungkanuparph S, Groger RK, Overton ET, Fraser VJ, Powderly WG (2006) Persistent low-level viraemia and virological failure in HIV-1-infected patients treated with highly active antiretroviral therapy. HIV Med 7:437-441
    • (2006) HIV Med , vol.7 , pp. 437-441
    • Sungkanuparph, S.1    Groger, R.K.2    Overton, E.T.3    Fraser, V.J.4    Powderly, W.G.5
  • 13
    • 34848818076 scopus 로고    scopus 로고
    • HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation
    • 17926652 1:CAS:528:DC%2BD2sXht1Ggu7%2FM
    • Steel A, Cox AE, Shamji MH, John L, Nelson M, Henderson DC, Gotch FM, Gazzard BG, Kelleher P (2007) HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation. Antivir Ther 12:971-975
    • (2007) Antivir Ther , vol.12 , pp. 971-975
    • Steel, A.1    Cox, A.E.2    Shamji, M.H.3    John, L.4    Nelson, M.5    Henderson, D.C.6    Gotch, F.M.7    Gazzard, B.G.8    Kelleher, P.9
  • 18
    • 0035824741 scopus 로고    scopus 로고
    • Durability of HIV-1 viral suppression over 3.3 years with multi-drug antiretroviral therapy in previously drug-naive individuals
    • 11740188 10.1097/00002030-200112070-00005 1:CAS:528: DC%2BD38XktF2qsQ%3D%3D
    • Phillips AN, Miller V, Sabin C, Cozzi Lepri A, Klauke S, Bickel M, Doerr HW, Hill A, Staszewski S (2001) Durability of HIV-1 viral suppression over 3.3 years with multi-drug antiretroviral therapy in previously drug-naive individuals. AIDS 15:2379-2384
    • (2001) AIDS , vol.15 , pp. 2379-2384
    • Phillips, A.N.1    Miller, V.2    Sabin, C.3    Cozzi Lepri, A.4    Klauke, S.5    Bickel, M.6    Doerr, H.W.7    Hill, A.8    Staszewski, S.9
  • 19
    • 0037131203 scopus 로고    scopus 로고
    • Prevalence and clinical correlates of HIV viremia ('blips') in patients with previous suppression below the limits of quantification
    • 12370502 10.1097/00002030-200210180-00008 1:CAS:528:DC%2BD38Xns1Cmtrc%3D
    • Sklar PA, Ward DJ, Baker RK, Wood KC, Gafoor Z, Alzola CF, Moorman AC, Holmberg SD (2002) Prevalence and clinical correlates of HIV viremia ('blips') in patients with previous suppression below the limits of quantification. AIDS 16:2035-2041
    • (2002) AIDS , vol.16 , pp. 2035-2041
    • Sklar, P.A.1    Ward, D.J.2    Baker, R.K.3    Wood, K.C.4    Gafoor, Z.5    Alzola, C.F.6    Moorman, A.C.7    Holmberg, S.D.8
  • 20
    • 27444436338 scopus 로고    scopus 로고
    • Intermittent episodes of detectable HIV viremia in patients receiving nonnucleoside reverse-transcriptase inhibitor-based or protease inhibitor-based highly active antiretroviral therapy regimens are equivalent in incidence and prognosis
    • 16206110 10.1086/496985 1:CAS:528:DC%2BD2MXht1Wit7%2FI
    • Sungkanuparph S, Overton ET, Seyfried W, Groger RK, Fraser VJ, Powderly WG (2005) Intermittent episodes of detectable HIV viremia in patients receiving nonnucleoside reverse-transcriptase inhibitor-based or protease inhibitor-based highly active antiretroviral therapy regimens are equivalent in incidence and prognosis. Clin Infect Dis 41:1326-1332
    • (2005) Clin Infect Dis , vol.41 , pp. 1326-1332
    • Sungkanuparph, S.1    Overton, E.T.2    Seyfried, W.3    Groger, R.K.4    Fraser, V.J.5    Powderly, W.G.6
  • 21
    • 0037040359 scopus 로고    scopus 로고
    • Genotypic analysis of plasma HIV-1 RNA after influenza vaccination of patients with previously undetectable viral loads
    • 11872996 10.1097/00002030-200203080-00004 1:CAS:528:DC%2BD38XivVyhsr0%3D
    • Kolber MA, Gabr AH, De La Rosa A, Glock JA, Jayaweera D, Miller N, Dickinson GM (2002) Genotypic analysis of plasma HIV-1 RNA after influenza vaccination of patients with previously undetectable viral loads. AIDS 16:537-542
    • (2002) AIDS , vol.16 , pp. 537-542
    • Kolber, M.A.1    Gabr, A.H.2    De La Rosa, A.3    Glock, J.A.4    Jayaweera, D.5    Miller, N.6    Dickinson, G.M.7
  • 23
    • 67651062415 scopus 로고    scopus 로고
    • Increased frequency of HIV-1 viral load blip rate observed after switching from Roche Cobas Amplicor to Cobas Taqman assay
    • 19553776 10.1097/QAI.0b013e3181aa13b3 1:CAS:528:DC%2BD1MXns1erur8%3D
    • Smit E, Bhattacharya S, Osman H, Taylor S (2009) Increased frequency of HIV-1 viral load blip rate observed after switching from Roche Cobas Amplicor to Cobas Taqman assay. J Acquir Immune Defic Syndr 51:364-365
    • (2009) J Acquir Immune Defic Syndr , vol.51 , pp. 364-365
    • Smit, E.1    Bhattacharya, S.2    Osman, H.3    Taylor, S.4
  • 24
    • 2142829435 scopus 로고    scopus 로고
    • Genotypic analysis of HIV-1 drug resistance at the limit of detection: Virus production without evolution in treated adults with undetectable HIV loads
    • 15073683 10.1086/382488 1:CAS:528:DC%2BD2cXktlCiur8%3D
    • Kieffer TL, Finucane MM, Nettles RE, Quinn TC, Broman KW, Ray SC, Persaud D, Siliciano RF (2004) Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads. J Infect Dis 189:1452-1465
    • (2004) J Infect Dis , vol.189 , pp. 1452-1465
    • Kieffer, T.L.1    Finucane, M.M.2    Nettles, R.E.3    Quinn, T.C.4    Broman, K.W.5    Ray, S.C.6    Persaud, D.7    Siliciano, R.F.8
  • 25
    • 42649135133 scopus 로고    scopus 로고
    • Immunologic, virologic, and clinical consequences of episodes of transient viremia during suppressive combination antiretroviral therapy
    • 18285709 10.1097/QAI.0b013e31816a1d4f
    • van Sighem A, Zhang S, Reiss P, Gras L, van der Ende M, Kroon F, Prins J, de Wolf F (2008) Immunologic, virologic, and clinical consequences of episodes of transient viremia during suppressive combination antiretroviral therapy. J Acquir Immune Defic Syndr 48:104-108
    • (2008) J Acquir Immune Defic Syndr , vol.48 , pp. 104-108
    • Van Sighem, A.1    Zhang, S.2    Reiss, P.3    Gras, L.4    Van Der Ende, M.5    Kroon, F.6    Prins, J.7    De Wolf, F.8
  • 27
    • 68149087762 scopus 로고    scopus 로고
    • Low-level viremia in HIV-1 infection: Consequences and implications for switching to a new regimen
    • 19487182 10.1310/hct1002-116
    • Cohen C (2009) Low-level viremia in HIV-1 infection: consequences and implications for switching to a new regimen. HIV Clin Trials 10:116-124
    • (2009) HIV Clin Trials , vol.10 , pp. 116-124
    • Cohen, C.1
  • 30
    • 77950485243 scopus 로고    scopus 로고
    • Correction of underquantification of human immunodeficiency virus type 1 load with the second version of the Roche Cobas AmpliPrep/Cobas TaqMan assay
    • 20164284 10.1128/JCM.01226-09
    • De Bel A, Marissens D, Debaisieux L, Liesnard C, Van den Wijngaert S, Lauwers S, Pierard D (2010) Correction of underquantification of human immunodeficiency virus type 1 load with the second version of the Roche Cobas AmpliPrep/Cobas TaqMan assay. J Clin Microbiol 48:1337-1342
    • (2010) J Clin Microbiol , vol.48 , pp. 1337-1342
    • De Bel, A.1    Marissens, D.2    Debaisieux, L.3    Liesnard, C.4    Van Den Wijngaert, S.5    Lauwers, S.6    Pierard, D.7
  • 31
    • 34250673163 scopus 로고    scopus 로고
    • Multicenter evaluation of the new Abbott RealTime assays for quantitative detection of human immunodeficiency virus type 1 and hepatitis C virus RNA
    • 17409216 10.1128/JCM.02385-06 1:CAS:528:DC%2BD2sXnsVKrt7c%3D
    • Schutten M, Peters D, Back NK, Beld M, Beuselinck K, Foulongne V, Geretti AM, Pandiani L, Tiemann C, Niesters HG (2007) Multicenter evaluation of the new Abbott RealTime assays for quantitative detection of human immunodeficiency virus type 1 and hepatitis C virus RNA. J Clin Microbiol 45:1712-1717
    • (2007) J Clin Microbiol , vol.45 , pp. 1712-1717
    • Schutten, M.1    Peters, D.2    Back, N.K.3    Beld, M.4    Beuselinck, K.5    Foulongne, V.6    Geretti, A.M.7    Pandiani, L.8    Tiemann, C.9    Niesters, H.G.10
  • 32
    • 67650308688 scopus 로고    scopus 로고
    • Reliability at the lower limits of HIV-1 RNA quantification in clinical samples: A comparison of RT-PCR versus bDNA assays
    • 19547711 10.1371/journal.pone.0006008
    • Lubelchek RJ, Max B, Sandusky CJ, Hota B, Barker DE (2009) Reliability at the lower limits of HIV-1 RNA quantification in clinical samples: a comparison of RT-PCR versus bDNA assays. PLoS ONE 4:e6008
    • (2009) PLoS ONE , vol.4 , pp. 6008
    • Lubelchek, R.J.1    Max, B.2    Sandusky, C.J.3    Hota, B.4    Barker, D.E.5
  • 33
    • 79954588023 scopus 로고    scopus 로고
    • Performance evaluation of the COBAS/TaqMan HIV-1 v2.0 in HIV-1 positive patients with low viral load: A comparative study
    • 21419171 10.1016/j.jviromet.2011.03.014 1:CAS:528:DC%2BC3MXkvFamt74%3D
    • Paba P, Fabeni L, Ciccozzi M, Perno CF, Ciotti M (2011) Performance evaluation of the COBAS/TaqMan HIV-1 v2.0 in HIV-1 positive patients with low viral load: a comparative study. J Virol Methods 173:399-402
    • (2011) J Virol Methods , vol.173 , pp. 399-402
    • Paba, P.1    Fabeni, L.2    Ciccozzi, M.3    Perno, C.F.4    Ciotti, M.5
  • 34
    • 78149491596 scopus 로고    scopus 로고
    • Lack of correlation between three commercial platforms for the evaluation of human immunodeficiency virus type 1 (HIV-1) viral load at the clinically critical lower limit of quantification
    • 20884287 10.1016/j.jcv.2010.08.016
    • Yan CS, Hanafi I, Kelleher AD, Carr AD, Amin J, McNally LP, Cunningham PH (2010) Lack of correlation between three commercial platforms for the evaluation of human immunodeficiency virus type 1 (HIV-1) viral load at the clinically critical lower limit of quantification. J Clin Virol 49:249-253
    • (2010) J Clin Virol , vol.49 , pp. 249-253
    • Yan, C.S.1    Hanafi, I.2    Kelleher, A.D.3    Carr, A.D.4    Amin, J.5    McNally, L.P.6    Cunningham, P.H.7
  • 35
    • 79952443361 scopus 로고    scopus 로고
    • Emerging integrase inhibitor resistance mutations in raltegravir-treated HIV-1-infected patients with low-level viremia
    • 21326075 10.1097/QAD.0b013e3283445834 1:CAS:528:DC%2BC3MXislOksLo%3D
    • Gallien S, Delaugerre C, Charreau I, Braun J, Boulet T, Barrail-Tran A, de Castro N, Molina JM, Kuritzkes DR (2011) Emerging integrase inhibitor resistance mutations in raltegravir-treated HIV-1-infected patients with low-level viremia. AIDS 25:665-669
    • (2011) AIDS , vol.25 , pp. 665-669
    • Gallien, S.1    Delaugerre, C.2    Charreau, I.3    Braun, J.4    Boulet, T.5    Barrail-Tran, A.6    De Castro, N.7    Molina, J.M.8    Kuritzkes, D.R.9
  • 36
    • 0034521513 scopus 로고    scopus 로고
    • Loss of antiretroviral drug susceptibility at low viral load during early virological failure in treatment-experienced patients
    • 11153669 10.1097/00002030-200012220-00009 1:CAS:528: DC%2BD3MXmtVaitw%3D%3D
    • Parkin NT, Deeks SG, Wrin MT, Yap J, Grant RM, Lee KH, Heeren D, Hellmanna NS, Petropoulos CJ (2000) Loss of antiretroviral drug susceptibility at low viral load during early virological failure in treatment-experienced patients. AIDS 14:2877-2887
    • (2000) AIDS , vol.14 , pp. 2877-2887
    • Parkin, N.T.1    Deeks, S.G.2    Wrin, M.T.3    Yap, J.4    Grant, R.M.5    Lee, K.H.6    Heeren, D.7    Hellmanna, N.S.8    Petropoulos, C.J.9
  • 38
    • 77950502841 scopus 로고    scopus 로고
    • Performance evaluation of the new Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test version 2.0 for quantification of human immunodeficiency virus type 1 RNA
    • 20164281 10.1128/JCM.01832-09 1:CAS:528:DC%2BC3cXmt1Kgtbs%3D
    • Pas S, Rossen JW, Schoener D, Thamke D, Pettersson A, Babiel R, Schutten M (2010) Performance evaluation of the new Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test version 2.0 for quantification of human immunodeficiency virus type 1 RNA. J Clin Microbiol 48:1195-1200
    • (2010) J Clin Microbiol , vol.48 , pp. 1195-1200
    • Pas, S.1    Rossen, J.W.2    Schoener, D.3    Thamke, D.4    Pettersson, A.5    Babiel, R.6    Schutten, M.7
  • 39
    • 77951864344 scopus 로고    scopus 로고
    • Detection of HIV-1 at between 20 and 49 copies per milliliter by the Cobas TaqMan HIV-1 v2.0 assay is associated with higher pretherapy viral load and less time on antiretroviral therapy
    • 20181895 10.1128/JCM.02388-09
    • Pascual-Pareja JF, Martinez-Prats L, Luczkowiak J, Fiorante S, Rubio R, Pulido F, Otero JR, Delgado R (2010) Detection of HIV-1 at between 20 and 49 copies per milliliter by the Cobas TaqMan HIV-1 v2.0 assay is associated with higher pretherapy viral load and less time on antiretroviral therapy. J Clin Microbiol 48:1911-1912
    • (2010) J Clin Microbiol , vol.48 , pp. 1911-1912
    • Pascual-Pareja, J.F.1    Martinez-Prats, L.2    Luczkowiak, J.3    Fiorante, S.4    Rubio, R.5    Pulido, F.6    Otero, J.R.7    Delgado, R.8
  • 45
    • 33846543809 scopus 로고    scopus 로고
    • Comparison of four commercial quantitative HIV-1 assays for viral load monitoring in clinical daily routine
    • 17243923 10.1515/CCLM.2007.008 1:CAS:528:DC%2BD2sXhsFKitrw%3D
    • Braun P, Ehret R, Wiesmann F, Zabbai F, Knickmann M, Kuhn R, Thamm S, Warnat G, Knechten H (2007) Comparison of four commercial quantitative HIV-1 assays for viral load monitoring in clinical daily routine. Clin Chem Lab Med 45:93-99
    • (2007) Clin Chem Lab Med , vol.45 , pp. 93-99
    • Braun, P.1    Ehret, R.2    Wiesmann, F.3    Zabbai, F.4    Knickmann, M.5    Kuhn, R.6    Thamm, S.7    Warnat, G.8    Knechten, H.9
  • 46
    • 67650021214 scopus 로고    scopus 로고
    • Evaluation of the Abbott m2000 RealTime human immunodeficiency virus type 1 (HIV-1) assay for HIV load monitoring in South Africa compared to the Roche Cobas AmpliPrep-Cobas Amplicor, Roche Cobas AmpliPrep-Cobas TaqMan HIV-1, and BioMerieux NucliSENS EasyQ HIV-1 assays
    • 19420172 10.1128/JCM.01761-08
    • Scott LE, Noble LD, Moloi J, Erasmus L, Venter WD, Stevens W (2009) Evaluation of the Abbott m2000 RealTime human immunodeficiency virus type 1 (HIV-1) assay for HIV load monitoring in South Africa compared to the Roche Cobas AmpliPrep-Cobas Amplicor, Roche Cobas AmpliPrep-Cobas TaqMan HIV-1, and BioMerieux NucliSENS EasyQ HIV-1 assays. J Clin Microbiol 47:2209-2217
    • (2009) J Clin Microbiol , vol.47 , pp. 2209-2217
    • Scott, L.E.1    Noble, L.D.2    Moloi, J.3    Erasmus, L.4    Venter, W.D.5    Stevens, W.6
  • 47
    • 78650907952 scopus 로고    scopus 로고
    • Comparative evaluation of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 version 2 test using the TaqMan 48 analyzer and the Abbott RealTime HIV-1 assay
    • 20980564 10.1128/JCM.01285-10
    • van Rensburg EJ, Tait K, Watt A, Schall R (2011) Comparative evaluation of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 version 2 test using the TaqMan 48 analyzer and the Abbott RealTime HIV-1 assay. J Clin Microbiol 49:377-379
    • (2011) J Clin Microbiol , vol.49 , pp. 377-379
    • Van Rensburg, E.J.1    Tait, K.2    Watt, A.3    Schall, R.4
  • 48
    • 66149147547 scopus 로고    scopus 로고
    • Impact of discrepancies between the Abbott realtime and cobas TaqMan assays for quantification of human immunodeficiency virus type 1 group M non-B subtypes
    • 19297599 10.1128/JCM.02134-08 1:STN:280:DC%2BD1MzgvFWnsw%3D%3D
    • Wirden M, Tubiana R, Marguet F, Leroy I, Simon A, Bonmarchand M, Ait-Arkoub Z, Murphy R, Marcelin AG, Katlama C, Calvez V (2009) Impact of discrepancies between the Abbott realtime and cobas TaqMan assays for quantification of human immunodeficiency virus type 1 group M non-B subtypes. J Clin Microbiol 47:1543-1545
    • (2009) J Clin Microbiol , vol.47 , pp. 1543-1545
    • Wirden, M.1    Tubiana, R.2    Marguet, F.3    Leroy, I.4    Simon, A.5    Bonmarchand, M.6    Ait-Arkoub, Z.7    Murphy, R.8    Marcelin, A.G.9    Katlama, C.10    Calvez, V.11
  • 50
    • 42449117109 scopus 로고    scopus 로고
    • CD8/CD38 activation yields important clinical information of effective antiretroviral therapy: Findings from the first year of the CIPRA-SA cohort
    • Glencross DK, Janossy G, Coetzee LM, Lawrie D, Scott LE, Sanne I, McIntyre JA, Stevens W (2008) CD8/CD38 activation yields important clinical information of effective antiretroviral therapy: findings from the first year of the CIPRA-SA cohort. Cytometry B Clin Cytom 74B(Suppl 1):S131-S140
    • (2008) Cytometry B Clin Cytom , vol.74 , Issue.SUPPL. 1
    • Glencross, D.K.1    Janossy, G.2    Coetzee, L.M.3    Lawrie, D.4    Scott, L.E.5    Sanne, I.6    McIntyre, J.A.7    Stevens, W.8
  • 51
    • 0032146161 scopus 로고    scopus 로고
    • CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency
    • 9704938 10.1097/00042560-199808010-00004 1:STN:280:DyaK1czmvVKgtA%3D%3D
    • Liu Z, Cumberland WG, Hultin LE, Kaplan AH, Detels R, Giorgi JV (1998) CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency. J Acquir Immune Defic Syndr Hum Retrovirol 18:332-340
    • (1998) J Acquir Immune Defic Syndr Hum Retrovirol , vol.18 , pp. 332-340
    • Liu, Z.1    Cumberland, W.G.2    Hultin, L.E.3    Kaplan, A.H.4    Detels, R.5    Giorgi, J.V.6


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