Intralymphatic allergen-specific immunotherapy: An effective and safe alternative treatment route for pollen-induced allergic rhinitis

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 2, 2013, Pages 412-420

  Hylander, Terese ^a   Latif, Leith ^b   Petersson Westin, Ulla ^b   Cardell, Lars Olaf ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allergen specific immunotherapy; allergic rhinitis; intralymphatic immunotherapy; seasonal allergic rhinitis

Indexed keywords

ALUTARD; IMMUNOGLOBULIN E; PLACEBO;

ABDOMINAL DISEASE; ADULT; ALLERGIC RHINITIS; ANGIONEUROTIC EDEMA; ARTICLE; BIRCH; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GRASS POLLEN; HUMAN; HUMAN CELL; IMMUNOTHERAPY; INFLAMMATORY CELL; INTRALYMPHATIC ALLERGEN SPECIFIC IMMUNOTHERAPY; LUNG DISEASE; LYMPHADENOPATHY; LYMPHOCYTE ACTIVATION; MALE; POLLEN ALLERGY; PRIORITY JOURNAL; PRURITUS; SEASONAL VARIATION; SKIN REDNESS; T LYMPHOCYTE; TREATMENT RESPONSE; URTICARIA;

ADULT; ALLERGENS; BETULA; CD4-POSITIVE T-LYMPHOCYTES; DESENSITIZATION, IMMUNOLOGIC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFLAMMATION; INJECTIONS, INTRALYMPHATIC; LEUKOCYTE COUNT; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; NASAL LAVAGE FLUID; NOSE; PILOT PROJECTS; POLLEN; RHINITIS, ALLERGIC, SEASONAL; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84873359531     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.10.056     Document Type: Article

References (42)

1. A.B. Kay Allergy and allergic diseases: first of two parts N Engl J Med 344 2001 30 37
2. J. Bousquet, N. Khaltaev, A.A. Cruz, J. Denburg, W.J. Fokkens, and A. Togias Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) Allergy 63 2008 8 160
3. A.J. Frew 25. Immunotherapy of allergic disease J Allergy Clin Immunol 111 2003 S712 S719
4. S.J. Till, J.N. Francis, K. Nouri-Aria, and S.R. Durham Mechanisms of immunotherapy J Allergy Clin Immunol 113 2004 1025 1034 quiz 35
5. M. Larche, C.A. Akdis, and R. Valenta Immunological mechanisms of allergen-specific immunotherapy Nat Rev Immunol 6 2006 761 771
6. J. Bousquet, R. Lockey, and H.J. Malling Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper J Allergy Clin Immunol 102 1998 558 562
7. L. Cox, H. Nelson, R. Lockey, C. Calabria, T. Chacko, and I. Finegold Allergen immunotherapy: a practice parameter third update J Allergy Clin Immunol 127 2011 S1 S55
8. A.J. Frew Allergen immunotherapy J Allergy Clin Immunol 125 2010 S306 S313
9. S.T. Holgate, and R. Polosa Treatment strategies for allergy and asthma Nat Rev Immunol 8 2008 218 230
10. G. Senti, P. Johansen, and T.M. Kundig Intralymphatic immunotherapy Curr Opin Allergy Clin Immunol 9 2009 537 543
11. J.M. Martinez-Gomez, P. Johansen, I. Erdmann, G. Senti, R. Crameri, and T.M. Kundig Intralymphatic injections as a new administration route for allergen-specific immunotherapy Int Arch Allergy Immunol 150 2009 59 65
12. R.M. Zinkernagel, S. Ehl, P. Aichele, S. Oehen, T. Kundig, and H. Hengartner Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity Immunol Rev 156 1997 199 209
13. R.M. Zinkernagel Localization dose and time of antigens determine immune reactivity Semin Immunol 12 2000 163 171 discussion 257-344
14. B.R. von Beust, P. Johansen, K.A. Smith, A. Bot, T. Storni, and T.M. Kundig Improving the therapeutic index of CpG oligodeoxynucleotides by intralymphatic administration Eur J Immunol 35 2005 1869 1876
15. K.J. Maloy, I. Erdmann, V. Basch, S. Sierro, T.A. Kramps, and R.M. Zinkernagel Intralymphatic immunization enhances DNA vaccination Proc Natl Acad Sci U S A 98 2001 3299 3303
16. P. Johansen, A.C. Haffner, F. Koch, K. Zepter, I. Erdmann, and K. Maloy Direct intralymphatic injection of peptide vaccines enhances immunogenicity Eur J Immunol 35 2005 568 574
17. G. Senti, R. Crameri, D. Kuster, P. Johansen, J.M. Martinez-Gomez, and N. Graf Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections J Allergy Clin Immunol 129 2012 1290 1296
18. G. Senti, B.M. Prinz Vavricka, I. Erdmann, M.I. Diaz, R. Markus, and S.J. McCormack Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial Proc Natl Acad Sci U S A 105 2008 17908 17912
19. T.M. Kundig Immunotherapy concepts under investigation Allergy 66 2011 60 62
20. D. Larenas-Linnemann, and L.S. Cox European allergen extract units and potency: review of available information Ann Allergy Asthma Immunol 100 2008 137 145
21. A.K. Ekman, R. Virtala, M. Fransson, M. Adner, M. Benson, and L. Jansson Systemic up-regulation of TLR4 causes lipopolysaccharide-induced augmentation of nasal cytokine release in allergic rhinitis Int Arch Allergy Immunol 159 2012 6 14
22. M. Fransson, M. Benson, G. Wennergren, and L.O. Cardell A role for neutrophils in intermittent allergic rhinitis Acta Otolaryngol 124 2004 616 620
23. O. Pfaar, J. Kleine-Tebbe, K. Hormann, and L. Klimek Allergen-specific immunotherapy: which outcome measures are useful in monitoring clinical trials? Immunol Allergy Clin North Am 31 2011 289 309 x
24. A. Mansson, O. Bachar, M. Adner, and L.O. Cardell Nasal CpG oligodeoxynucleotide administration induces a local inflammatory response in nonallergic individuals Allergy 64 2009 1292 1300
25. J. Hellgren, A. Cervin, S. Nordling, A. Bergman, and L.O. Cardell Allergic rhinitis and the common cold-high cost to society Allergy 65 2010 776 783
26. T.B. Casale Status of immunotherapy: current and future J Allergy Clin Immunol 113 2004 1036 1039
27. L.K. James, and S.R. Durham Update on mechanisms of allergen injection immunotherapy Clin Exp Allergy 38 2008 1074 1088
28. G. Senna, E. Ridolo, M. Calderon, C. Lombardi, G.W. Canonica, and G. Passalacqua Evidence of adherence to allergen-specific immunotherapy Curr Opin Allergy Clin Immunol 9 2009 544 548
29. P. Popper, C.R. Mantyh, S.R. Vigna, J.E. Maggio, and P.W. Mantyh The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes Peptides 9 1988 257 267
30. V.F. Ragusa, and A. Massolo Non-fatal systemic reactions to subcutaneous immunotherapy: a 20-year experience comparison of two 10-year periods Eur Ann Allergy Clin Immunol 36 2004 52 55
31. A.B. Kay Allergy and allergic diseases: second of two parts N Engl J Med 344 2001 109 113
32. M.H. Shamji, and S.R. Durham Mechanisms of immunotherapy to aeroallergens Clin Exp Allergy 41 2011 1235 1246
33. A.O. Eifan, M.H. Shamji, and S.R. Durham Long-term clinical and immunological effects of allergen immunotherapy Curr Opin Allergy Clin Immunol 11 2011 586 593
34. L.M. Lichtenstein, K. Ishizaka, P.S. Norman, A.K. Sobotka, and B.M. Hill IgE antibody measurements in ragweed hay fever: relationship to clinical severity and the results of immunotherapy J Clin Invest 52 1973 472 482
35. G.J. Gleich, E.M. Zimmermann, L.L. Henderson, and J.W. Yunginger Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study J Allergy Clin Immunol 70 1982 261 271
36. A. Mansson, O. Bachar, M. Adner, S. Bjornsson, and L.O. Cardell Leukocyte phenotype changes induced by specific immunotherapy in patients with birch allergy J Investig Allergol Clin Immunol 20 2010 476 483
37. H.J. Malling Immunotherapy as an effective tool in allergy treatment Allergy 53 1998 461 472
38. W.W. Storms Minimal persistent inflammation, an emerging concept in the nature and treatment of allergic rhinitis: the possible role of leukotrienes Ann Allergy Asthma Immunol 91 2003 131 140
39. O. Cevit, S.G. Kendirli, M. Yilmaz, D.U. Altintas, and G.B. Karakoc Specific allergen immunotherapy: effect on immunologic markers and clinical parameters in asthmatic children J Investig Allergol Clin Immunol 17 2007 286 291
40. D.M. Dorfman, and A. Shahsafaei CD69 expression correlates with expression of other markers of Th1 T cell differentiation in peripheral T cell lymphomas Hum Pathol 33 2002 330 334
41. H. Zola Markers of cell lineage, differentiation and activation J Biol Regul Homeost Agents 14 2000 218 219
42. S.F. Ziegler, F. Ramsdell, and M.R. Alderson The activation antigen CD69 Stem Cells 12 1994 456 465