Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function

Journal of the American Society of Nephrology

Volumn 24, Issue 2, 2013, Pages 309-319

  Schmidt, Insa M ^a,c   Hall, Isaac E ^a   Kale, Sujata ^a   Lee, Sik ^b   He, Chuan Hua ^a   Lee, Yashang ^a   Chupp, Geoffrey L ^a   Moeckel, Gilbert W ^a   Lee, Chun Geun ^a   Elias, Jack A ^a   Parikh, Chirag R ^a   Cantley, Lloyd G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Jeonbuk National University Medical School and Hospital   (South Korea)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRP 39 PROTEIN; CHITINASE; OXYGEN RADICAL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; YKL 40 PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DELAYED GRAFT FUNCTION; DIALYSIS; ENZYME ACTIVATION; IN VITRO STUDY; KIDNEY DONOR; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY TRANSPLANTATION; KIDNEY TUBULE CELL; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL;

EID: 84873358096     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012060579     Document Type: Article

References (52)

1. Molitoris BA, Levin A, Warnock DG, Joannidis M, Mehta RL, Kellum JA, Ronco C, Shah SV; Acute Kidney Injury Network working group: Improving outcomes of acute kidney injury: Report of an initiative. Nat Clin Pract Nephrol 3:439-442, 2007
2. Coca SG, Yusuf B, Shlipak MG, Garg AX, Parikh CR: Long-term risk of mortality and other adverse outcomes after acute kidney injury: A systematic review and meta-analysis. AmJ Kidney Dis 53:961-973, 2009
3. Wald R, Quinn RR, Luo J, Li P, Scales DC, Mamdani MM, Ray JG; University of Toronto Acute Kidney Injury ResearchGroup: Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA 302:1179-1185, 2009
4. James MT, Hemmelgarn BR, Wiebe N, Pannu N, Manns BJ, Klarenbach SW, Tonelli M; Alberta Kidney Disease Network: Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: A cohort study. Lancet 376:2096-2103, 2010
5. Waikar SS, Curhan GC, Wald R, McCarthy EP, Chertow GM: Declining mortality in patients with acute renal failure, 1988 to 2002. J Am Soc Nephrol 17:1143-1150, 2006
6. Anderson S, Eldadah B, Halter JB, Hazzard WR, Himmelfarb J, Horne FM, Kimmel PL, Molitoris BA, Murthy M, O'Hare AM, Schmader KE, High KP: Acute kidney injury in older adults. J Am Soc Nephrol 22:28-38, 2011
7. Elias JA, Homer RJ, Hamid Q, Lee CG: Chitinases and chitinase-like proteins in T (H) 2 inflammation and asthma. J Allergy Clin Immunol 116:497-500, 2005
8. Rejman JJ, Hurley WL: Isolation and characterization of a novel 39 kilodalton whey protein from bovine mammary secretions collected during the nonlactating period. Biochem Biophys Res Commun 150:329-334, 1988
9. Hakala BE, White C, Recklies AD: Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem 268:25803-25810, 1993
10. Hartl D, He CH, Koller B, Da Silva CA, Kobayashi Y, Lee CG, Flavell RA, Elias JA: Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independentmechanism. J Immunol 182:5098-5106, 2009
11. Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med 206:1149-1166, 2009
12. Johansen JS, Cintin C, Jørgensen M, Kamby C, Price PA: SerumYKL-40: A new potential marker of prognosis and location of metastases of patients with recurrent breast cancer. Eur J Cancer 31 A: 1437-1442, 1995
13. Ober C, Chupp GL: The chitinase and chitinase-like proteins: A review of genetic and functional studies in asthma and immune-mediated diseases. Curr Opin Allergy Clin Immunol 9:401-408, 2009
14. Bojesen SE, Johansen JS, Nordestgaard BG: Plasma YKL-40 levels in healthy subjects fromthe general population. Clin Chim Acta 412:709-712, 2011
15. Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA: A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med 357:2016-2027, 2007
16. Rathcke CN, Vestergaard H: YKL-40-an emerging biomarker in cardiovascular disease and diabetes. Cardiovasc Diabetol 8:61, 2009
17. Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, McCaughan GW: Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization. Hepatology 38:577-588, 2003
18. Fontana RJ, Dienstag JL, Bonkovsky HL, Sterling RK, Naishadham D, Goodman ZD, Lok AS, Wright EC, Su GL; HALT-C Trial Group: Serum fibrosis markers are associated with liver disease progression in nonresponder patients with chronic hepatitis C. Gut 59:1401-1409, 2010
19. Thöm I, Andritzky B, Schuch G, Burkholder I, Edler L, Johansen JS, Bokemeyer C, Schumacher U, Laack E: Elevated pretreatment serum concentration of YKL-40-An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer. Cancer 116:4114-4121, 2010
20. Francescone RA, Scully S, Faibish M, Taylor SL, Oh D, Moral L, Yan W, Bentley B, Shao R: Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J Biol Chem 286:15332-15343, 2011
21. Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, Ruhrberg C, Cantley LG: Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 22:317-326, 2011
22. Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA: Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol 73:479-501, 2011
23. Sheridan AM, Schwartz JH, Kroshian VM, Tercyak AM, Laraia J, Masino S, Lieberthal W: Renal mouse proximal tubular cells are more susceptible than MDCK cells to chemical anoxia. Am J Physiol 265:F342-F350, 1993
24. Karihaloo A, O'Rourke DA, Nickel C, Spokes K, Cantley LG: Differential MAPK pathways utilized for HGF-and EGF-dependent renal epithelial morphogenesis. J Biol Chem 276:9166-9173, 2001
25. Mühlberger I, Perco P, Fechete R, Mayer B, Oberbauer R: Biomarkers in renal transplantation ischemia reperfusion injury. Transplantation 88 [Suppl]: S14-S19, 2009
26. Hall IE, Yarlagadda SG, Coca SG, Wang Z, Doshi M, Devarajan P, Han WK, Marcus RJ, Parikh CR: IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. J AmSocNephrol 21:189-197, 2010
27. Hall IE, Doshi MD, Poggio ED, Parikh CR: A comparison of alternative serum biomarkers with creatinine for predicting allograft function after kidney transplantation. Transplantation 91:48-56, 2011
28. Wu H, Chen G, Wyburn KR, Yin J, Bertolino P, Eris JM, Alexander SI, Sharland AF, Chadban SJ: TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 117:2847-2859, 2007
29. Bonventre JV, Weinberg JM: Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 14:2199-2210, 2003
30. Mizuno S, Nakamura T: Prevention of neutrophil extravasation by hepatocyte growth factor leads to attenuations of tubular apoptosis and renal dysfunction in mouse ischemic kidneys. Am J Pathol 166:1895-1905, 2005
31. Sandovici M, Henning RH, van Goor H, Helfrich W, de Zeeuw D, Deelman LE: Systemic gene therapy with interleukin-13 attenuates renal ischemia-reperfusion injury. Kidney Int 73:1364-1373, 2008
32. Schwarz C, Hauser P, Steininger R, Regele H, Heinze G, Mayer G, Oberbauer R: Failure of BCL-2 up-regulation in proximal tubular epithelial cells of donor kidney biopsy specimens is associated with apoptosis and delayed graft function. Lab Invest 82:941-948, 2002
33. Mas VR, Archer KJ, Yanek K, Dumur CI, Capparuccini MI, Mangino MJ, King A, Gibney EM, Fisher R, Posner M, Maluf D: Gene expression patterns in deceased donor kidneys developing delayed graft function after kidney transplantation. Transplantation 85:626-635, 2008
34. Ricardo SD, van Goor H, Eddy AA: Macrophage diversity in renal injury and repair. J Clin Invest 118:3522-3530, 2008
35. Jiang B, Liao R: The paradoxical role of inflammation in cardiac repair and regeneration. J Cardiovasc Transl Res 3:410-416, 2010
36. Moers C, Smits JM, Maathuis MH, Treckmann J, van Gelder F, Napieralski BP, van Kasterop-Kutz M, van der Heide JJ, Squifflet JP, van Heurn E, Kirste GR, Rahmel A, Leuvenink HG, Paul A, Pirenne J, Ploeg RJ: Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 360:7-19, 2009
37. Ferguson R, Grinyó J, Vincenti F, Kaufman DB, Woodle ES, Marder BA, Citterio F, Marks WH, Agarwal M, Wu D, Dong Y, Garg P: Immunosuppression with belatacept-based, corticosteroid-avoiding regimens in de novo kidney transplant recipients. Am J Transplant 11:66-76, 2011
38. Vincenti F, Larsen C, Durrbach A, Wekerle T, Nashan B, Blancho G, Lang P, Grinyo J, Halloran PF, Solez K, Hagerty D, Levy E, Zhou W, Natarajan K, Charpentier B; Belatacept Study Group: Costimulation blockade with belatacept in renal transplantation. N Engl J Med 353:770-781, 2005
39. Menke J, Iwata Y, Rabacal WA, Basu R, Yeung YG, Humphreys BD, Wada T, Schwarting A, Stanley ER, Kelley VR: CSF-1 signals directly to renal tubular epithelial cells to mediate repair inmice. JClin Invest 119:2330-2342, 2009
40. Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, Nowlin BT, Pei H, Chen L, Zheng JJ, Carroll TJ, Pollard JW, McMahon AP, Lang RA, Duffield JS: MacrophageWnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A 107:4194-4199, 2010
41. Lin SL, Castaño AP, Nowlin BT, Lupher ML Jr, Duffield JS: Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations. J Immunol 183:6733-6743, 2009
42. Carlos CP, Mendes GE, Miquelin AR, Luz MA, da Silva CG, van Rooijen N, Coimbra TM, Burdmann EA: Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity. Transplantation 89:1362-1370, 2010
43. Perico N, Cattaneo D, Sayegh MH, Remuzzi G: Delayed graft function in kidney transplantation. Lancet 364:1814-1827, 2004
44. Tang IY, Meier-Kriesche HU, Kaplan B: Immunosuppressive strategies to improve outcomes of kidney transplantation. Semin Nephrol 27:377-392, 2007
45. US Renal Data System: USRDS 2010 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2010
46. Hall IE, Koyner JL, Doshi MD, Marcus RJ, Parikh CR: Urine cystatin C as a biomarker of proximal tubular function immediately after kidney transplantation. Am J Nephrol 33:407-413, 2011
47. Kjaergaard AD, Bojesen SE, Johansen JS, Nordestgaard BG: Elevated plasma YKL-40 levels and ischemic stroke in the general population. Ann Neurol 68:672-680, 2010
48. Bilim O, Takeishi Y, Kitahara T, Ishino M, Sasaki T, Suzuki S, Shishido T, Kubota I: Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure. J Card Fail 16:873-879, 2010
49. Schafer JA, Watkins ML, Li L, Herter P, Haxelmans S, Schlatter E: A simplified method for isolation of large numbers of defined nephron segments. Am J Physiol 273:F650-F657, 1997
50. Schmitt R, Marlier A, Cantley LG: Zag expression during aging suppresses proliferation after kidney injury. J Am Soc Nephrol 19:2375-2383, 2008
51. Hader C, Marlier A, Cantley L: Mesenchymal-epithelial transition in epithelial response to injury: The role of Foxc2. Oncogene 29:1031-1040, 2010
52. Johnston O, O'kelly P, Spencer S, Donohoe J, Walshe JJ, Little DM, Hickey D, Conlon PJ: Reduced graft function (with or without dialysis) vs immediate graft function-a comparison of long-term renal allograft survival. Nephrol Dial Transplant 21:2270-2274, 2006