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Volumn 7, Issue 1, 2013, Pages 13-32

Relapsed and refractory lymphoid neoplasms and multiple myeloma with a focus on carfilzomib

Author keywords

Carfilzomib; Epoxyketone; Myeloma; Proteasome inhibitor; Second generation

Indexed keywords

BORTEZOMIB; CARFILZOMIB; CYCLOPHOSPHAMIDE; CYTARABINE; DELANZOMIB; DEXAMETHASONE; ENTINOSTAT; HISTONE DEACETYLASE INHIBITOR; IDARUBICIN; IXAZOMIB CITRATE; LENALIDOMIDE; OPROZOMIB; PANOBINOSTAT; POMALIDOMIDE; PROTEASOME INHIBITOR; RITUXIMAB; SALINOSPORAMIDE A; THALIDOMIDE; VALPROIC ACID; VORINOSTAT;

EID: 84873345627     PISSN: 11775475     EISSN: 11775491     Source Type: Journal    
DOI: 10.2147/BTT.S24580     Document Type: Review
Times cited : (14)

References (117)
  • 2
    • 42949096020 scopus 로고    scopus 로고
    • Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases
    • Rabl J, Smith DM, Yu Y, Chang S-C, Goldberg AL, Cheng Y. Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell. 2008;30(3):360-368.
    • (2008) Mol Cell , vol.30 , Issue.3 , pp. 360-368
    • Rabl, J.1    Smith, D.M.2    Yu, Y.3    Chang, S.-C.4    Goldberg, A.L.5    Cheng, Y.6
  • 3
    • 33749069075 scopus 로고    scopus 로고
    • ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome
    • Liu C-W, Li X, Thompson D, et al. ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol Cell. 2006;24(1):39-50.
    • (2006) Mol Cell , vol.24 , Issue.1 , pp. 39-50
    • Liu, C.-W.1    Li, X.2    Thompson, D.3
  • 4
    • 0033176770 scopus 로고    scopus 로고
    • The base of the proteasome regulatory particle exhibits chaperone-like activity
    • Braun BC, Glickman M, Kraft R, et al. The base of the proteasome regulatory particle exhibits chaperone-like activity. Nat Cell Biol. 1999;1(4):221-226.
    • (1999) Nat Cell Biol , vol.1 , Issue.4 , pp. 221-226
    • Braun, B.C.1    Glickman, M.2    Kraft, R.3
  • 5
    • 0034327510 scopus 로고    scopus 로고
    • Catalytic activities of the 20S proteasome: A multicatalytic proteinase complex
    • Orlowski M, Wilk S. Catalytic activities of the 20S proteasome: a multicatalytic proteinase complex. Arch Biochem Biophys. 2000;383(1):1-16.
    • (2000) Arch Biochem Biophys , vol.383 , Issue.1 , pp. 1-16
    • Orlowski, M.1    Wilk, S.2
  • 6
    • 0034514655 scopus 로고    scopus 로고
    • Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome
    • Keith DW. Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. Semin Cell Dev Biol. 2000;11(3):141-148.
    • (2000) Semin Cell Dev Biol , vol.11 , Issue.3 , pp. 141-148
    • Keith, D.W.1
  • 7
    • 39749143840 scopus 로고    scopus 로고
    • Discovery of a potent, selective, and orally Active proteasome inhibitor for the treatment of cancer
    • Dorsey BD, Iqbal M, Chatterjee S, et al. Discovery of a potent, selective, and orally Active proteasome inhibitor for the treatment of cancer. J Med Chem. 2008;51(4):1068-1072.
    • (2008) J Med Chem , vol.51 , Issue.4 , pp. 1068-1072
    • Dorsey, B.D.1    Iqbal, M.2    Chatterjee, S.3
  • 8
    • 33646841837 scopus 로고    scopus 로고
    • Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate
    • Kisselev AF, Callard A, Goldberg AL. Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. J Biol Chem. 2006;281(13):8582-8590.
    • (2006) J Biol Chem , vol.281 , Issue.13 , pp. 8582-8590
    • Kisselev, A.F.1    Callard, A.2    Goldberg, A.L.3
  • 9
    • 0031973736 scopus 로고    scopus 로고
    • Immunoproteasome assembly: Cooperative incorporation of interferon γ (IFN-γ)-inducible subunits
    • Griffin TA, Nandi D, Cruz M, et al. Immunoproteasome assembly: cooperative incorporation of interferon γ (IFN-γ)-inducible subunits. J Exp Med. 1998;187(1):97-104.
    • (1998) J Exp Med , vol.187 , Issue.1 , pp. 97-104
    • Griffin, T.A.1    Nandi, D.2    Cruz, M.3
  • 10
    • 77649237033 scopus 로고    scopus 로고
    • Building on bortezomib: Second-generation proteasome inhibitors as anti-cancer therapy
    • Dick LR, Fleming PE. Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy. Drug Discov Today. 2010;15(5-6):243-249.
    • (2010) Drug Discov Today , vol.15 , Issue.5-6 , pp. 243-249
    • Dick, L.R.1    Fleming, P.E.2
  • 11
    • 33744832401 scopus 로고    scopus 로고
    • United States Food and Drug Administration approval summary: Bortezomib for the treatment of progressive multiple myeloma after one prior therapy
    • Kane RC, Farrell AT, Sridhara R, Pazdur R. United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy. Clin Cancer Res. 2006;12(10):2955-2960.
    • (2006) Clin Cancer Res , vol.12 , Issue.10 , pp. 2955-2960
    • Kane, R.C.1    Farrell, A.T.2    Sridhara, R.3    Pazdur, R.4
  • 12
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood. 2010;116(5):679-686.
    • (2010) Blood , vol.116 , Issue.5 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 13
    • 78650303860 scopus 로고    scopus 로고
    • Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: A randomised Phase 3study
    • Cavo M, Tacchetti P, Patriarca F, et al. Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised Phase 3study. Lancet. 2010;376(9758):2075-2085.
    • (2010) Lancet , vol.376 , Issue.9758 , pp. 2075-2085
    • Cavo, M.1    Tacchetti, P.2    Patriarca, F.3
  • 14
    • 84870734426 scopus 로고    scopus 로고
    • The improved efficacy of bortezomib containing induction regimens (BCIR) versus nonbortezomib containing induction regimens (NBCIR) in transplant-eligible patients with multiple myeloma (MM): Meta-analysis of Phase III randomized controlled trials (RCTs)
    • Nooka AK, Kaufman JL, Behera M, et al. The improved efficacy of bortezomib containing induction regimens (BCIR) versus nonbortezomib containing induction regimens (NBCIR) in transplant-eligible patients with multiple myeloma (MM): meta-analysis of Phase III randomized controlled trials (RCTs). ASH Annual Meeting Abstracts. 2011;118(21):3994.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3994
    • Nooka, A.K.1    Kaufman, J.L.2    Behera, M.3
  • 15
    • 78649681350 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly bortezomib in multiple myeloma patients
    • Bringhen S, Larocca A, Rossi D, et al. Efficacy and safety of once-weekly bortezomib in multiple myeloma patients. Blood. 2010;116(23):4745-4753.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4745-4753
    • Bringhen, S.1    Larocca, A.2    Rossi, D.3
  • 16
    • 52649114697 scopus 로고    scopus 로고
    • Bortezomib-induced peripheral neuropathy in multiple myeloma: A comprehensive review of the literature
    • Argyriou AA, Iconomou G, Kalofonos HP. Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature. Blood. 2008;112(5):1593-1599.
    • (2008) Blood , vol.112 , Issue.5 , pp. 1593-1599
    • Argyriou, A.A.1    Iconomou, G.2    Kalofonos, H.P.3
  • 18
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: A randomised, Phase 3, non-inferiority study
    • Moreau P, Pylypenko H, Grosicki S, et al. Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, Phase 3, non-inferiority study. Lancet Oncol. 2011;12(5):431-440.
    • (2011) Lancet Oncol , vol.12 , Issue.5 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3
  • 19
    • 53049106912 scopus 로고    scopus 로고
    • Molecular basis of bortezomib resistance: Proteasome subunit β5 (PSMB5) gene mutation and overexpression of PSMB5 protein
    • Oerlemans R, Franke NE, Assaraf YG, et al. Molecular basis of bortezomib resistance: proteasome subunit β5 (PSMB5) gene mutation and overexpression of PSMB5 protein. Blood. 2008;112(6):2489-2499.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2489-2499
    • Oerlemans, R.1    Franke, N.E.2    Assaraf, Y.G.3
  • 20
    • 61849152933 scopus 로고    scopus 로고
    • Many facets of bortezomib resistance/susceptibility
    • Kumar S, Rajkumar SV. Many facets of bortezomib resistance/susceptibility. Blood. 2008;112(6):2177-2178.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2177-2178
    • Kumar, S.1    Rajkumar, S.V.2
  • 21
    • 77950238258 scopus 로고    scopus 로고
    • Evaluation of the proteasome inhibitor MLN9708in preclinical models of human cancer
    • Kupperman E, Lee EC, Cao Y, et al. Evaluation of the proteasome inhibitor MLN9708in preclinical models of human cancer. Cancer Res. 2010;70(5):1970-1980.
    • (2010) Cancer Res , vol.70 , Issue.5 , pp. 1970-1980
    • Kupperman, E.1    Lee, E.C.2    Cao, Y.3
  • 22
    • 84857919694 scopus 로고    scopus 로고
    • Investigational agent MLN9708, an oral proteasome inhibitor in patients (Pts) with relapsed and/or refractory multiple myeloma (MM): Results from the expansion cohorts of a Phase 1 dose-escalation study
    • Richardson PG, Baz R, Wang L, et al. Investigational agent MLN9708, an oral proteasome inhibitor in patients (Pts) with relapsed and/or refractory multiple myeloma (MM): results from the expansion cohorts of a Phase 1 dose-escalation study. ASH Annual Meeting Abstracts. 2011;118(21):301.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 301
    • Richardson, P.G.1    Baz, R.2    Wang, L.3
  • 23
    • 84862697766 scopus 로고    scopus 로고
    • Weekly dosing of the investigational oral proteasome inhibitor MLN9708in patients with relapsed and/or refractory multiple myeloma: Results from a Phase 1 dose-escalation study
    • Kumar S, Bensinger WI, Reeder CB, et al. Weekly dosing of the investigational oral proteasome inhibitor MLN9708in patients with relapsed and/or refractory multiple myeloma: results from a Phase 1 dose-escalation study. ASH Annual Meeting Abstracts. 2011;118(21):816.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 816
    • Kumar, S.1    Bensinger, W.I.2    Reeder, C.B.3
  • 24
    • 84863643928 scopus 로고    scopus 로고
    • Phase 1/2study of oral MLN9708, a novel, investigational proteasome inhibitor in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM)
    • Berdeja JG, Richardson PG, Lonial S, et al. Phase 1/2study of oral MLN9708, a novel, investigational proteasome inhibitor in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM). ASH Annual Meeting Abstracts. 2011;118(21):479.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 479
    • Berdeja, J.G.1    Richardson, P.G.2    Lonial, S.3
  • 25
    • 84988241358 scopus 로고    scopus 로고
    • International uniform response criteria for multiple myeloma
    • Durie BGM, Harousseau JL, Miguel JS, et al. International uniform response criteria for multiple myeloma. Leukemia. 2006;20(9):1467-1473.
    • (2006) Leukemia , vol.20 , Issue.9 , pp. 1467-1473
    • Durie, B.G.M.1    Harousseau, J.L.2    Miguel, J.S.3
  • 26
    • 84870742647 scopus 로고    scopus 로고
    • Oral dosing of the novel proteasome inhibitor CEP-18770 shows marked anti-myeloma effects in SCID-Hu models of multiple myeloma
    • Sanchez E, Li M, Steinberg JA, et al. Oral dosing of the novel proteasome inhibitor CEP-18770 shows marked anti-myeloma effects in SCID-Hu models of multiple myeloma. ASH Annual Meeting Abstracts. 2009;114(22):1840.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 1840
    • Sanchez, E.1    Li, M.2    Steinberg, J.A.3
  • 27
    • 41949110089 scopus 로고    scopus 로고
    • CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
    • Piva R, Ruggeri B, Williams M, et al. CEP-18770: a novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood. 2008;111(5):2765-2775.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2765-2775
    • Piva, R.1    Ruggeri, B.2    Williams, M.3
  • 28
    • 85172063753 scopus 로고    scopus 로고
    • NIH, In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 26, 2012
    • NIH. Phase I study of the proteosome inhibitor CEP 18770in patients with solid tumours or non-Hodgkin's lymphomas. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2007. Available from: http://clinicaltrials.gov/show/NCT00572637. Accessed February 26, 2012.
    • (2007) Phase I study of the proteosome inhibitor CEP 18770in patients with solid tumours or non-Hodgkin's lymphomas
  • 30
    • 85172060373 scopus 로고    scopus 로고
    • NIH, In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 26, 2012
    • NIH. CEP-18770in combination with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01348919. Accessed February 26, 2012.
    • (2011) CEP-18770in combination with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma
  • 31
    • 84870755998 scopus 로고    scopus 로고
    • Efficacy and tolerability of CEP-18770in combination with dexamethasone and lenalidomide using a SCID-Hu model of multiple myeloma (MM)
    • November 18
    • Sanchez E, Nichols CM, Lam AC, et al. Efficacy and tolerability of CEP-18770in combination with dexamethasone and lenalidomide using a SCID-Hu model of multiple myeloma (MM). ASH Annual Meeting Abstracts. November 18, 2011;118(21):2946.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 2946
    • Sanchez, E.1    Nichols, C.M.2    Lam, A.C.3
  • 32
    • 33750209537 scopus 로고    scopus 로고
    • A novel proteasome inhibitor NPI-0052 as an anticancer therapy
    • Chauhan D, Hideshima T, Anderson KC. A novel proteasome inhibitor NPI-0052 as an anticancer therapy. Br J Cancer. 2006;95:961-965.
    • (2006) Br J Cancer , vol.95 , pp. 961-965
    • Chauhan, D.1    Hideshima, T.2    Anderson, K.C.3
  • 33
    • 77649237983 scopus 로고    scopus 로고
    • Pharmacodynamic and efficacy studies of a novel proteasome NPI-0052in human plasmacytoma Xenograft Mouse Model
    • Singh AV, Lloyd GK, Palladino MA, Chauhan D, Anderson KC. Pharmacodynamic and efficacy studies of a novel proteasome NPI-0052in human plasmacytoma Xenograft Mouse Model. ASH Annual Meeting Abstracts. 2008;112(11):3665.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , Issue.11 , pp. 3665
    • Singh, A.V.1    Lloyd, G.K.2    Palladino, M.A.3    Chauhan, D.4    Anderson, K.C.5
  • 34
    • 27644562277 scopus 로고    scopus 로고
    • A novel orally active inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
    • Chauhan D, Catley L, Li G, et al. A novel orally active inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell. 2005;8(5):407-419.
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 407-419
    • Chauhan, D.1    Catley, L.2    Li, G.3
  • 35
    • 79951489147 scopus 로고    scopus 로고
    • Phase 1 clinical trial of the novel structure proteasome inhibitor NPI-0052in patients with relapsed and relapsed/refractory multiple myeloma (MM)
    • Richardson P, Hofmeister C, Jakubowiak A, et al. Phase 1 clinical trial of the novel structure proteasome inhibitor NPI-0052in patients with relapsed and relapsed/refractory multiple myeloma (MM). ASH Annual Meeting Abstracts. 2009;114(22):431.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 431
    • Richardson, P.1    Hofmeister, C.2    Jakubowiak, A.3
  • 36
    • 77949315484 scopus 로고    scopus 로고
    • Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Ciccarelli B, Richardson PG, Palladino MA, Anderson KC. Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma. Blood. 2010;115(4):834-845.
    • (2010) Blood , vol.115 , Issue.4 , pp. 834-845
    • Chauhan, D.1    Singh, A.V.2    Ciccarelli, B.3    Richardson, P.G.4    Palladino, M.A.5    Anderson, K.C.6
  • 37
    • 85172052552 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 26, 2012
    • NIH. Phase 1 clinical trial of NPI-0052in patients with advanced solid tumor malignancies or refractory lymphoma. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2006. Available from: http://clinicaltrials.gov/show/NCT00396864. Accessed February 26, 2012.
    • (2006) Phase 1 clinical trial of NPI-0052in patients with advanced solid tumor malignancies or refractory lymphoma
  • 38
    • 85172056140 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 26, 2012
    • NIH. Phase 1 clinical trial of NPI-0052in patients with relapsed or relapsed/refractory multiple myeloma. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2007. Available from: http://clinicaltrials.gov/show/NCT00461045. Accessed February 26, 2012.
    • (2007) Phase 1 clinical trial of NPI-0052in patients with relapsed or relapsed/refractory multiple myeloma
  • 40
    • 78649755360 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Aujay M, et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood. 2010;116(23):4906-4915.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4906-4915
    • Chauhan, D.1    Singh, A.V.2    Aujay, M.3
  • 41
    • 81155138545 scopus 로고    scopus 로고
    • A Phase I, open-label, dose-escalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors
    • Abstr 3075
    • Papadopoulos K, Mendelson D, Tolcher A, et al. A Phase I, open-label, dose-escalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors. J Clin Oncol. 2011;Suppl 29:Abstr 3075.
    • (2011) J Clin Oncol , Issue.SUPPL. 29
    • Papadopoulos, K.1    Mendelson, D.2    Tolcher, A.3
  • 42
    • 85172058388 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Avilable from:, Accessed February 27, 2012
    • NIH. Open-label study of the safety and activity of ONX 0912in patients with hematological malignancies. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Avilable from: http://clinicaltrials.gov/show/NCT01416428. Accessed February 27, 2012.
    • (2011) Open-label study of the safety and activity of ONX 0912in patients with hematological malignancies
  • 43
    • 0033230405 scopus 로고    scopus 로고
    • Towards subunit-specific proteasome inhibitors: Synthesis and evaluation of peptide α′, β′-epoxyketones
    • Elofsson M, Splittgerber U, Myung J, Mohan R, Crews CM. Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide α′, β′-epoxyketones. Chemistry and Biology. 1999;6(11):811-822.
    • (1999) Chemistry and Biology , vol.6 , Issue.11 , pp. 811-822
    • Elofsson, M.1    Splittgerber, U.2    Myung, J.3    Mohan, R.4    Crews, C.M.5
  • 45
    • 84859633087 scopus 로고    scopus 로고
    • Neurodegeneration induced by bortezomib exposure in vitro occurs via proteasome independent mechanisms
    • Arastu-Kapur S, Ball AJ, Anderl JL, Bennett MK, Kirk CJ. Neurodegeneration induced by bortezomib exposure in vitro occurs via proteasome independent mechanisms. ASH Annual Meeting Abstracts. 2009;114(22):2859.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 2859
    • Arastu-Kapur, S.1    Ball, A.J.2    Anderl, J.L.3    Bennett, M.K.4    Kirk, C.J.5
  • 46
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006;5(9):769-784.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 47
    • 65549136174 scopus 로고    scopus 로고
    • Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells
    • Fuchs O, Provaznikova D, Marinov I, Kuzelova K, Spicka I. Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells. Cardiovasc Hematol Disord Drug Targets. 2009;9(1):62-77.
    • (2009) Cardiovasc Hematol Disord Drug Targets , vol.9 , Issue.1 , pp. 62-77
    • Fuchs, O.1    Provaznikova, D.2    Marinov, I.3    Kuzelova, K.4    Spicka, I.5
  • 48
    • 81055149914 scopus 로고    scopus 로고
    • Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma
    • Hideshima T, Richardson PG, Anderson KC. Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma. Mol Cancer Ther. 2011;10(11):2034-2042.
    • (2011) Mol Cancer Ther , vol.10 , Issue.11 , pp. 2034-2042
    • Hideshima, T.1    Richardson, P.G.2    Anderson, K.C.3
  • 49
    • 9144220841 scopus 로고    scopus 로고
    • Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications
    • Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. Proc Natl Acad Sci U S A. 2004;101(2):540-545.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.2 , pp. 540-545
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 50
    • 68749093915 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis
    • Zhang QL, Wang L, Zhang YW, et al. The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis. Leukemia. 2009;23(8):1507-1514.
    • (2009) Leukemia , vol.23 , Issue.8 , pp. 1507-1514
    • Zhang, Q.L.1    Wang, L.2    Zhang, Y.W.3
  • 51
    • 69349097803 scopus 로고    scopus 로고
    • Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma
    • Badros A, Burger AM, Philip S, et al. Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma. Clin Cancer Res. 2009;15(16):5250-5257.
    • (2009) Clin Cancer Res , vol.15 , Issue.16 , pp. 5250-5257
    • Badros, A.1    Burger, A.M.2    Philip, S.3
  • 52
    • 77956121105 scopus 로고    scopus 로고
    • Co-treatment with panobinostat enhances bortezomib-induced unfolded protein response, endoplasmic reticulum stress and apoptosis of human mantle cell lymphoma cells
    • Rao R, Fiskus W, Yang Y, et al. Co-treatment with panobinostat enhances bortezomib-induced unfolded protein response, endoplasmic reticulum stress and apoptosis of human mantle cell lymphoma cells. ASH Annual Meeting Abstracts. 2008;112(11):887.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , Issue.11 , pp. 887
    • Rao, R.1    Fiskus, W.2    Yang, Y.3
  • 53
    • 80052784486 scopus 로고    scopus 로고
    • Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo
    • Dasmahapatra G, Lembersky D, Son MP, et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Mol Cancer Ther. 2011;10(9):1686-1697.
    • (2011) Mol Cancer Ther , vol.10 , Issue.9 , pp. 1686-1697
    • Dasmahapatra, G.1    Lembersky, D.2    Son, M.P.3
  • 54
    • 77953937449 scopus 로고    scopus 로고
    • The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo
    • Dasmahapatra G, Lembersky D, Kramer L, et al. The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo. Blood. 2010;115(22):4478-4487.
    • (2010) Blood , vol.115 , Issue.22 , pp. 4478-4487
    • Dasmahapatra, G.1    Lembersky, D.2    Kramer, L.3
  • 55
    • 79960487350 scopus 로고    scopus 로고
    • Treatment with histone deacetylase 6-specific inhibitor WT-161 disrupts hsp90 function, abrogates aggresome formation and sensitizes human mantle cell lymphoma cells to lethal ER stress induced by proteasome inhibitor carfilzomib
    • Rao R, Fiskus W, Balusu R, et al. Treatment with histone deacetylase 6-specific inhibitor WT-161 disrupts hsp90 function, abrogates aggresome formation and sensitizes human mantle cell lymphoma cells to lethal ER stress induced by proteasome inhibitor carfilzomib. ASH Annual Meeting Abstracts. 2010;116(21):2856.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 2856
    • Rao, R.1    Fiskus, W.2    Balusu, R.3
  • 56
    • 85172053852 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Study of carfilzomib and vorinostat for relapsed or refractory lymphoma. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01276717. Accessed February 27, 2012.
    • (2011) Study of carfilzomib and vorinostat for relapsed or refractory lymphoma
  • 58
    • 85172056291 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Carfilzomib plus panobinostat in relapsed/refractory multiple myeloma (MM). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01301807. Accessed February 27, 2012.
    • (2011) Carfilzomib plus panobinostat in relapsed/refractory multiple myeloma (MM)
  • 59
    • 85172049475 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Study of the combination of panobinostat and carfilzomib in patients qith relapsed/refractory multiple myeloma. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01496118. Accessed February 27, 2012.
    • (2011) Study of the combination of panobinostat and carfilzomib in patients qith relapsed/refractory multiple myeloma
  • 60
    • 33847410207 scopus 로고    scopus 로고
    • The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells
    • Stapnes C, Døskeland AP, Hatfield K, et al. The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. Br J Haematol. 2007;136(6):814-828.
    • (2007) Br J Haematol , vol.136 , Issue.6 , pp. 814-828
    • Stapnes, C.1    Døskeland, A.P.2    Hatfield, K.3
  • 61
    • 84874929075 scopus 로고    scopus 로고
    • Sensitivity of pediatric acute leukemia cells to bortezomib and epoxyketone-based proteasome inhibitors: Correlations with proteasome subunit expression
    • Niewerth D, Franke N, Jansen G, et al. Sensitivity of pediatric acute leukemia cells to bortezomib and epoxyketone-based proteasome inhibitors: correlations with proteasome subunit expression. ASH Annual Meeting Abstracts. 2011;118(21):1513.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 1513
    • Niewerth, D.1    Franke, N.2    Jansen, G.3
  • 62
    • 85172067775 scopus 로고    scopus 로고
    • The novel proteasome inhibitor carfilzomib functions independently of p53 to induce potent cytotoxicity in primary chronic lymphocytic leukemia cells and a defective NF-{kappa}B response
    • Gupta SV, Hertlein EK, Woyach JA, et al. The novel proteasome inhibitor carfilzomib functions independently of p53 to induce potent cytotoxicity in primary chronic lymphocytic leukemia cells and a defective NF-{kappa}B response. ASH Annual Meeting Abstracts. 2011;118(21):3510.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3510
    • Gupta, S.V.1    Hertlein, E.K.2    Woyach, J.A.3
  • 63
    • 84873340961 scopus 로고    scopus 로고
    • Carfilzomib, an irreversible proteasome inhibitor induces long-term growth inhibition of mantle cell lymphoma in vivo
    • Zhang L, Qian J, Ou Z, et al. Carfilzomib, an irreversible proteasome inhibitor induces long-term growth inhibition of mantle cell lymphoma in vivo. ASH Annual Meeting Abstracts. 2011;118(21):3740.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3740
    • Zhang, L.1    Qian, J.2    Ou, Z.3
  • 64
    • 79956121097 scopus 로고    scopus 로고
    • Carfilzomib (CFZ): A novel proteasome inhibitor that induces cell cycle arrest and cell death in rituximab-chemotherapy resistant lymphoma and potentiates the anti-tumor activity of chemotherapeutic agents
    • Gu J, Hernandez-Ilizaliturri FJ, Kaufman GP, Mavis C, Czuczman MS. Carfilzomib (CFZ): a novel proteasome inhibitor that induces cell cycle arrest and cell death in rituximab-chemotherapy resistant lymphoma and potentiates the anti-tumor activity of chemotherapeutic agents. ASH Annual Meeting Abstracts. 2010;116(21):4908.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 4908
    • Gu, J.1    Hernandez-Ilizaliturri, F.J.2    Kaufman, G.P.3    Mavis, C.4    Czuczman, M.S.5
  • 65
    • 85172045365 scopus 로고    scopus 로고
    • The novel proteasome inhibitor carfilzomib (CFZ) potentiates the anti-tumor activity of chemotherapeutic agents in rituximab-chemotherapy resistant lymphoma through inducing G2/M cell cycle arrest and cell death
    • Gu J, Czuczman NM, Kaufman GP, Mavis C, Hernandez-Ilizaliturri FJ, Czuczman MS. The novel proteasome inhibitor carfilzomib (CFZ) potentiates the anti-tumor activity of chemotherapeutic agents in rituximab-chemotherapy resistant lymphoma through inducing G2/M cell cycle arrest and cell death. ASH Annual Meeting Abstracts. 2011;118(21):4970.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 4970
    • Gu, J.1    Czuczman, N.M.2    Kaufman, G.P.3    Mavis, C.4    Hernandez-Ilizaliturri, F.J.5    Czuczman, M.S.6
  • 66
    • 84873384027 scopus 로고    scopus 로고
    • Chemo-resistance in diffuse large cell lymphoma: Novel drug combinations targeting NFAT/NF-Kb growth/survival/chemo-resistance signaling pathways in validated novel experimental systems
    • Pham LV, Tamayo AT, Li C, Lee J, Fayad L, Ford RJ. Chemo-resistance in diffuse large cell lymphoma: novel drug combinations targeting NFAT/NF-Kb growth/survival/chemo-resistance signaling pathways in validated novel experimental systems. ASH Annual Meeting Abstracts. 2011;118(21):1428.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 1428
    • Pham, L.V.1    Tamayo, A.T.2    Li, C.3    Lee, J.4    Fayad, L.5    Ford, R.J.6
  • 67
    • 79953300497 scopus 로고    scopus 로고
    • Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to antitumor activity in Waldenstrom's macroglobulinemia
    • Sacco A, Aujay M, Morgan B, et al. Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to antitumor activity in Waldenstrom's macroglobulinemia. Clin Cancer Res. 2011;17(7):1753-1764.
    • (2011) Clin Cancer Res , vol.17 , Issue.7 , pp. 1753-1764
    • Sacco, A.1    Aujay, M.2    Morgan, B.3
  • 68
    • 65649139708 scopus 로고    scopus 로고
    • Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)
    • Zhou H-J, Aujay MA, Bennett MK, et al. Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J Med Chem. 2009;52(9):3028-3038.
    • (2009) J Med Chem , vol.52 , Issue.9 , pp. 3028-3038
    • Zhou, H.-J.1    Aujay, M.A.2    Bennett, M.K.3
  • 69
    • 79955498420 scopus 로고    scopus 로고
    • Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: A link to clinical adverse events
    • Arastu-Kapur S, Anderl JL, Kraus M, et al. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res. 2011;17(9):2734-2743.
    • (2011) Clin Cancer Res , vol.17 , Issue.9 , pp. 2734-2743
    • Arastu-Kapur, S.1    Anderl, J.L.2    Kraus, M.3
  • 70
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • Kuhn DJ, Chen Q, Voorhees PM, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood. 2007;110(9):3281-3290.
    • (2007) Blood , vol.110 , Issue.9 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3
  • 71
    • 34447116376 scopus 로고    scopus 로고
    • Antitumora of PR-171, a novel irreversible inhibitor of the proteasome
    • Demo SD, Kirk CJ, Aujay MA, et al. Antitumora of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res. 2007;67(13):6383-6391.
    • (2007) Cancer Res , vol.67 , Issue.13 , pp. 6383-6391
    • Demo, S.D.1    Kirk, C.J.2    Aujay, M.A.3
  • 72
    • 18244406798 scopus 로고    scopus 로고
    • Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib
    • Berkers CR, Verdoes M, Lichtman E, et al. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Meth. 2005;2(5):357-362.
    • (2005) Nat Meth , vol.2 , Issue.5 , pp. 357-362
    • Berkers, C.R.1    Verdoes, M.2    Lichtman, E.3
  • 73
    • 84872192025 scopus 로고    scopus 로고
    • Selective inhibition of the proteasome's {beta}2 catalytic subunit alone does not induce cytotoxicity, but resensitizes bortezomib-refractory myeloma cells for bortezomib treatment
    • Kraus M, Florea B, Bader J, et al. Selective inhibition of the proteasome's {beta}2 catalytic subunit alone does not induce cytotoxicity, but resensitizes bortezomib-refractory myeloma cells for bortezomib treatment. ASH Annual Meeting Abstracts. 2011;118(21):2915.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 2915
    • Kraus, M.1    Florea, B.2    Bader, J.3
  • 74
    • 70350708810 scopus 로고    scopus 로고
    • Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
    • Parlati F, Lee SJ, Aujay M, et al. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 2009;114(16):3439-3447.
    • (2009) Blood , vol.114 , Issue.16 , pp. 3439-3447
    • Parlati, F.1    Lee, S.J.2    Aujay, M.3
  • 75
    • 85172064518 scopus 로고    scopus 로고
    • Potent inhibition of multiple proteasome subunits by carfilzomib in multiple myeloma and solid tumor patients
    • Lee SJ, Woo TM, Arastu-Kapur S, Wong AF, Renau TE, Kirk CJ. Potent inhibition of multiple proteasome subunits by carfilzomib in multiple myeloma and solid tumor patients. ASH Annual Meeting Abstracts. 2011;118(21):5068.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 5068
    • Lee, S.J.1    Woo, T.M.2    Arastu-Kapur, S.3    Wong, A.F.4    Renau, T.E.5    Kirk, C.J.6
  • 76
    • 84862486640 scopus 로고    scopus 로고
    • A phase 1b/2study of prolonged infusion carfilzomib in patients with relapsed and/or refractory (R/R) multiple myeloma: Updated efficacy and tolerability from the completed 20/56mg/m2 expansion cohort of PX-171-007
    • Papadopoulos KP, Lee P, Singhal S, et al. A phase 1b/2study of prolonged infusion carfilzomib in patients with relapsed and/or refractory (R/R) multiple myeloma: updated efficacy and tolerability from the completed 20/56mg/m2 expansion cohort of PX-171-007. ASH Annual Meeting Abstracts. 2011;118(21):2930.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 2930
    • Papadopoulos, K.P.1    Lee, P.2    Singhal, S.3
  • 77
    • 80053148350 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats
    • Yang J, Wang Z, Fang Y, et al. Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats. Drug Metab Dispos. 2011;39(10):1873-1882.
    • (2011) Drug Metab Dispos , vol.39 , Issue.10 , pp. 1873-1882
    • Yang, J.1    Wang, Z.2    Fang, Y.3
  • 78
    • 81155138545 scopus 로고    scopus 로고
    • A Phase I, open-label, dose-escalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors
    • Abstr 3075
    • Papadopoulos K, Mendelson D, Tolcher A, et al. A Phase I, open-label, dose-escalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors. J Clin Oncol. 2011;Suppl 29:Abstr 3075.
    • (2011) J Clin Oncol , Issue.SUPPL. 29
    • Papadopoulos, K.1    Mendelson, D.2    Tolcher, A.3
  • 79
    • 72549116835 scopus 로고    scopus 로고
    • A Phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
    • O'Connor OA, Stewart AK, Vallone M, et al. A Phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin Cancer Res. 2009;15(22):7085-7091.
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 7085-7091
    • O'Connor, O.A.1    Stewart, A.K.2    Vallone, M.3
  • 80
    • 0037111832 scopus 로고    scopus 로고
    • Phase I trial of the proteasome inhibitor PS-341in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase I trial of the proteasome inhibitor PS-341in patients with refractory hematologic malignancies. J Clin Oncol. 2002;20(22):4420-4427.
    • (2002) J Clin Oncol , vol.20 , Issue.22 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 81
    • 28444436266 scopus 로고    scopus 로고
    • Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma
    • Lonial S, Waller EK, Richardson PG, et al. Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood. 2005;106(12):3777-3784.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3777-3784
    • Lonial, S.1    Waller, E.K.2    Richardson, P.G.3
  • 82
    • 50249150555 scopus 로고    scopus 로고
    • Phase 1single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies
    • Alsina M, Trudel S, Vallone M, Molineaux C, Kunkel L, Goy A. Phase 1single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies. ASH Annual Meeting Abstracts. 2007;110(11):411.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 411
    • Alsina, M.1    Trudel, S.2    Vallone, M.3    Molineaux, C.4    Kunkel, L.5    Goy, A.6
  • 83
    • 70349643684 scopus 로고    scopus 로고
    • Final results of PX-171-003-A0, part 1 of an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
    • Abstr 8504
    • Jagannath S, Vij R, Stewart K, et al. Final results of PX-171-003-A0, part 1 of an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). J Clin Oncol. 2009;27(Suppl 15s):Abstr 8504.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15S
    • Jagannath, S.1    Vij, R.2    Stewart, K.3
  • 84
    • 84857923822 scopus 로고    scopus 로고
    • Final results from the bortezomib-naive group of PX-171-004, a Phase 2study of single-agent carfilzomib in patients with relapsed and/or refractory MM
    • Vij R, Kaufman JL, Jakubowiak AJ, et al. Final results from the bortezomib-naive group of PX-171-004, a Phase 2study of single-agent carfilzomib in patients with relapsed and/or refractory MM. ASH Annual Meeting Abstracts. 2011;118(21):813.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 813
    • Vij, R.1    Kaufman, J.L.2    Jakubowiak, A.J.3
  • 85
    • 77249116395 scopus 로고    scopus 로고
    • PX-171-004, An ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM); updated results from the bortezomib-treated cohort
    • Siegel D, Wang L, Orlowski RZ, et al. PX-171-004, An ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM); updated results from the bortezomib-treated cohort. ASH Annual Meeting Abstracts. 2009;114(22):303.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 303
    • Siegel, D.1    Wang, L.2    Orlowski, R.Z.3
  • 86
    • 78649237411 scopus 로고    scopus 로고
    • Results of an ongoing open-label, Phase II study of carfilzomib in patients with relapsed and/or refractory multiple myeloma (R/R MM)
    • Abstr 8000
    • Vij R, Siegel D, Kaufman J, et al. Results of an ongoing open-label, Phase II study of carfilzomib in patients with relapsed and/or refractory multiple myeloma (R/R MM). J Clin Oncol. 2010;28(Suppl 15s):Abstr 8000.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15S
    • Vij, R.1    Siegel, D.2    Kaufman, J.3
  • 87
    • 78549295085 scopus 로고    scopus 로고
    • Phase II study of carfilzomib in patients with relapsed/refractory multiple myeloma and renal insufficiency
    • Abstr 8128
    • Badros A, Vij R, Martin T, et al. Phase II study of carfilzomib in patients with relapsed/refractory multiple myeloma and renal insufficiency. J Clin Oncol. 2010;28(Suppl 15s):Abstr 8128.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15S
    • Badros, A.1    Vij, R.2    Martin, T.3
  • 88
    • 84862688138 scopus 로고    scopus 로고
    • Interim results from PX-171-006, a Phase (Ph) II multicenter dose-expansion study of carfilzomib (CFZ), lenalidomide (LEN), and low-dose dexamethasone (loDex) in relapsed and/or refractory multiple myeloma (R/R MM)
    • Abstr 8025
    • Wang M, Bensinger W, Martin T, et al. Interim results from PX-171-006, a Phase (Ph) II multicenter dose-expansion study of carfilzomib (CFZ), lenalidomide (LEN), and low-dose dexamethasone (loDex) in relapsed and/or refractory multiple myeloma (R/R MM). J Clin Oncol. 2011;(Suppl 29):Abstr 8025.
    • (2011) J Clin Oncol , Issue.SUPPL. 29
    • Wang, M.1    Bensinger, W.2    Martin, T.3
  • 89
    • 84863644110 scopus 로고    scopus 로고
    • A randomized, multicenter, Phase (Ph) III study comparing carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (Dex) to LEN and Dex in patients (Pts) with relapsed multiple myeloma (MM)
    • abstr TPS225
    • Moreau P, Palumbo A, Stewart A, et al. A randomized, multicenter, Phase (Ph) III study comparing carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (Dex) to LEN and Dex in patients (Pts) with relapsed multiple myeloma (MM). J Clin Oncol. 2011;(Suppl 29): abstr TPS225.
    • (2011) J Clin Oncol , Issue.SUPPL. 29
    • Moreau, P.1    Palumbo, A.2    Stewart, A.3
  • 90
    • 84857261392 scopus 로고    scopus 로고
    • Final results of a frontline phase 1/2 dtudy of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in multiple myeloma (MM)
    • Jakubowiak AJ, Dytfeld D, Jagannath S, et al. Final results of a frontline phase 1/2 dtudy of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in multiple myeloma (MM). ASH Annual Meeting Abstracts. 2011;118(21):631.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 631
    • Jakubowiak, A.J.1    Dytfeld, D.2    Jagannath, S.3
  • 91
    • 84864568291 scopus 로고    scopus 로고
    • Carfilzomib combined with thalidomide and dexamethasone (CARTHADEX) as induction treatment prior to high-dose melphalan (HDM) in newly diagnosed patients with multiple myeloma (MM). a trial of the European Myeloma Network EMN
    • Sonneveld P, Hacker E, Zweegman S, et al. Carfilzomib combined with thalidomide and dexamethasone (CARTHADEX) as induction treatment prior to high-dose melphalan (HDM) in newly diagnosed patients with multiple myeloma (MM). a trial of the European Myeloma Network EMN. ASH Annual Meeting Abstracts. 2011;118(21):633.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 633
    • Sonneveld, P.1    Hacker, E.2    Zweegman, S.3
  • 92
    • 84859760906 scopus 로고    scopus 로고
    • Integrated safety from Phase 2studies of monotherapy carfilzomib in patients with relapsed and refractory multiple myeloma (MM): An updated analysis
    • Singhal S, Siegel DS, Martin T, et al. Integrated safety from Phase 2studies of monotherapy carfilzomib in patients with relapsed and refractory multiple myeloma (MM): an updated analysis. ASH Annual Meeting Abstracts. 2011;118(21):1876.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 1876
    • Singhal, S.1    Siegel, D.S.2    Martin, T.3
  • 93
    • 84873330252 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. A study of carfilzomib maintenance therapy in subjects previously enrolled in carfilzomib treatment protocols. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2009. Available from: http://clinicaltrials.gov/show/NCT00884312. Accessed February 27, 2012.
    • (2009) A study of carfilzomib maintenance therapy in subjects previously enrolled in carfilzomib treatment protocols
  • 94
    • 79955503406 scopus 로고    scopus 로고
    • Baseline peripheral neuropathy does not impact the efficacy and tolerability of the novel proteasome inhibitor carfilzomib (CFZ): Results of a subset analysis of a Phase 2 trial in patients with relapsed and refractory multiple myeloma (R/R MM)
    • Martin T, Singhal SB, Vij R, et al. Baseline peripheral neuropathy does not impact the efficacy and tolerability of the novel proteasome inhibitor carfilzomib (CFZ): results of a subset analysis of a Phase 2 trial in patients with relapsed and refractory multiple myeloma (R/R MM). ASH Annual Meeting Abstracts. 2010;116(21):3031.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 3031
    • Martin, T.1    Singhal, S.B.2    Vij, R.3
  • 95
    • 84872213259 scopus 로고    scopus 로고
    • Unfavorable cytogenetic characteristics do not adversely impact response rates in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib on the 003 (A1) study
    • Jakubowaik AJ, Siegel DS, Singhal S, et al. Unfavorable cytogenetic characteristics do not adversely impact response rates in patients with relapsed and/or refractory multiple myeloma treated with single-agent carfilzomib on the 003 (A1) study. ASH Annual Meeting Abstracts. 2011;118(21):1875.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 1875
    • Jakubowaik, A.J.1    Siegel, D.S.2    Singhal, S.3
  • 96
    • 79951490687 scopus 로고    scopus 로고
    • Phase I study of carfilzomib in patients (Pts) with relapsed and refractory multiple myeloma (MM) and varying degrees of renal insufficiency
    • Badros AZ, Vij R, Martin T, et al. Phase I study of carfilzomib in patients (Pts) with relapsed and refractory multiple myeloma (MM) and varying degrees of renal insufficiency. ASH Annual Meeting Abstracts. 2009;114(22):3877.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 3877
    • Badros, A.Z.1    Vij, R.2    Martin, T.3
  • 97
    • 84862495709 scopus 로고    scopus 로고
    • Multivariate modelling reveals evidence of a dose-response relationship in Phase 2 studies of single-agent carfilzomib
    • Squifflet P, Michiels S, Siegel DS, Vij R, Ro S, Buyse ME. Multivariate modelling reveals evidence of a dose-response relationship in Phase 2 studies of single-agent carfilzomib. ASH Annual Meeting Abstracts. 2011;118(21):1877.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 1877
    • Squifflet, P.1    Michiels, S.2    Siegel, D.S.3    Vij, R.4    Ro, S.5    Buyse, M.E.6
  • 98
    • 84859785906 scopus 로고    scopus 로고
    • The speed of response to single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma: An exploratory analysis of results from 2multicenter Phase 2 clinical yrials
    • Wang L, Siegel DS, Jakubowiak AJ, et al. The speed of response to single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma: an exploratory analysis of results from 2multicenter Phase 2 clinical yrials. ASH Annual Meeting Abstracts. 2011;118(21):3969.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3969
    • Wang, L.1    Siegel, D.S.2    Jakubowiak, A.J.3
  • 99
    • 80053152019 scopus 로고    scopus 로고
    • Long-term treatment and tolerability of the novel proteasome inhibitor carfilzomib (CFZ) in patients with relapsed and/or refractory multiple myeloma (R/R MM)
    • Jagannath S, Vij R, Kaufman JL, et al. Long-term treatment and tolerability of the novel proteasome inhibitor carfilzomib (CFZ) in patients with relapsed and/or refractory multiple myeloma (R/R MM). ASH Annual Meeting Abstracts. 2010;116(21):1953.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 1953
    • Jagannath, S.1    Vij, R.2    Kaufman, J.L.3
  • 100
    • 84859750766 scopus 로고    scopus 로고
    • PX-171-003-A1, an open-label, single-arm, Phase (Ph) II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (R/R MM): Long-term follow-up and subgroup analysis
    • Abstr 8027
    • Siegel D, Martin T, Wang M, et al. PX-171-003-A1, an open-label, single-arm, Phase (Ph) II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (R/R MM): long-term follow-up and subgroup analysis. J Clin Oncol. 2011;Suppl 29:Abstr 8027.
    • (2011) J Clin Oncol , Issue.SUPPL. 29
    • Siegel, D.1    Martin, T.2    Wang, M.3
  • 101
    • 85172055511 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Carfilzomib in patients with relapsed acute myeloid or acute lymphoblastic leukemia (AML ALL). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010. Available from: http:/clinicaltrials.gov/show/NCT01137747. Accessed February 27, 2012.
    • (2010) Carfilzomib in patients with relapsed acute myeloid or acute lymphoblastic leukemia (AML ALL)
  • 103
    • 85172043538 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 26, 2012
    • NIH. Carfilzomib in treating patients with relapsed or refractory T-cell lymphoma. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http:/clinicaltrials.gov/show/NCT01336920. Accessed February 26, 2012.
    • (2011) Carfilzomib in treating patients with relapsed or refractory T-cell lymphoma
  • 104
    • 85172065659 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from, Accessed February 27, 2012
    • NIH. Phase 1b multicenter study of carfilzomib with lenalidomide and dexamethasone in relapsed multiple myeloma. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2008. Available from http:/clinicaltrials.gov/show/NCT00603447. Accessed February 27, 2012.
    • (2008) Phase 1b multicenter study of carfilzomib with lenalidomide and dexamethasone in relapsed multiple myeloma
  • 106
    • 85172051332 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Study of carfilzomib for multiple myeloma patients who are relapsed/refractory to bortezomib-containing treatments. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01365559. Accessed February 27, 2012.
    • (2011) Study of carfilzomib for multiple myeloma patients who are relapsed/refractory to bortezomib-containing treatments
  • 107
    • 85172066413 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Trial of carfilzomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma (CARMYSAP). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010. Available from: http://clinicaltrials.gov/show/NCT01279694. Accessed February 27, 2012.
    • (2010) Trial of carfilzomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma (CARMYSAP)
  • 109
    • 85172058210 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Arry-520 + carfilzomib for multiple myeloma (MM). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012. Available from: http://clinicaltrials.gov/show/NCT01372540. Accessed February 27, 2012.
    • (2012) Arry-520 + carfilzomib for multiple myeloma (MM)
  • 112
    • 85172064150 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Carfilzomib, rituximab and dexamethasone in Waldenstrom's macroglobulinemia (CaRD). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01470196. Accessed February 27, 2012.
    • (2011) Carfilzomib, rituximab and dexamethasone in Waldenstrom's macroglobulinemia (CaRD)
  • 113
    • 85172052834 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Infusional carfilzomib in patients with relapsed or refractory multiple myeloma. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01351623. Accessed February 27, 2012.
    • (2011) Infusional carfilzomib in patients with relapsed or refractory multiple myeloma
  • 114
    • 85172060127 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Carfilzomib, cyclophosphamide and dexamethasone in newly diagnosed multiple myeloma patients (CCD). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01346787. Accessed February 27, 2012.
    • (2011) Carfilzomib, cyclophosphamide and dexamethasone in newly diagnosed multiple myeloma patients (CCD)
  • 115
    • 85172059915 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Available from:, Accessed February 27, 2012
    • NIH. Carfilzomib, lenalidomide, and dexamethasone in new multiple myeloma patients. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011. Available from: http://clinicaltrials.gov/show/NCT01402284. Accessed February 27, 2012.
    • (2011) Carfilzomib, lenalidomide, and dexamethasone in new multiple myeloma patients
  • 117
    • 85172051744 scopus 로고    scopus 로고
    • NIH., In:, [website on the Internet]. Bethesda, MD: US National Library of Medicine, Avilable from:, Accessed February 27, 2012
    • NIH. A study of carfilzomib vs best supportive care in subjects with relapsed and refractory multiple myeloma (FOCUS). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010. Avilable from: http://clinicaltrials.gov/show/NCT01302392. Accessed February 27, 2012.
    • (2010) A study of carfilzomib vs best supportive care in subjects with relapsed and refractory multiple myeloma (FOCUS)


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