Influence of fluphenazine dihydrochloride on model dipalmitoylphosphatidylcholine membranes and human genotoxically damaged lymphocyte cultures

Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia

Volumn 25, Issue 3, 2012, Pages 270-273

  Petrus, Joanna ^a   Czarnik Matusewicz, Boguslawa ^a   Jaszczyszyn, Agata ^b   Ga̧siorowski, Kazimierz ^b   Cieślik Boczula, Katarzyna ^a   Wesołowska, Olga ^b   Michalak, Krystyna ^b   Świa̧tek, Piotr ^b   Malinka, Wiesław ^b  

^a UNIVERSITY OF WROC AW   (Poland)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Chemosensitizing agents; Differential scanning calorimetry; Fluphenazine dihydrochloride; Membrane interactions; P glycoprotein; Rhodamine 123

Indexed keywords

BENZO[A]PYRENE; DIPALMITOYLPHOSPHATIDYLCHOLINE; FLUPHENAZINE; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123;

ARTICLE; CELL DAMAGE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFECT; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; MEMBRANE FLUIDITY; MEMBRANE STRUCTURE; PHOSPHOLIPID BILAYER; PHOSPHOLIPID MEMBRANE; PROTEIN TRANSPORT; TEMPERATURE SENSITIVITY;

EID: 84873327387     PISSN: 08670609     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Boyum A.: Separation of leukocytes from blood and bone marrow Scand. J. Clin. Lab. Invest., 21, 77, 1968.
2. 31P NMR studies. J. Phys. Chem. B., 113, 15495, 2009.
3. Drori S., Eytan G.D., Assaraf Y.G.: Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability. Eur. J. Biochem., 228, 1020, 1995.
4. 31P NMR studies on the interaction of some phenothiazine derivatives with dipalmitoylphosphatidylcholine model membranes. Biochim. Biophys. Acta, 507, 185, 1978.
5. Hendrich A.B. et al.: The alterations of lipid bilayer fluidity induced by newly synthesized phenothiazine derivative. Biophys. Chem., 98, 275, 2002.
6. Hendrich A.B. et al.: Newphenothiazine-type multidrug resistance modifiers: anti-MDR activity versus membrane perturbing potency. Biochem. Biophys. Res. Commun., 304, 260, 2003.
7. Hien T.T. et al.: Molecular mechanizm of suppression of MDR1 by puerarin from Pueraria lobata via NF-ȨB pathway and cAMP-responsive element transcriptional activitydependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. Mol. Nutr. Food Res., 54, 918, 2010.
8. Jaszczyszyn A., Ga̧siorowski K.: Mechanizmy chemoprewencyjnego działania nowo syntezowanych analogow flufenazyny. Borgis'Wydawnictwo Medyczne, Warszawa 2006.
9. Jaszczyszyn A., Ga̧siorowski K.: Aktywność chemouwrazliwiaja̧ca flufenazyny w chemoprewencji późnej nowotworu. In: Promocja zdrowia, profilaktyka i opieka w chorobach przewlektych - współczesne problemy. T. 1. Abramczyk A et al. (eds). A & A Optimed., 171, Wrocław 2011.
10. Jaszczyszyn A. et al.: New fluphenazine analogues as inhibitors of P-glycoprotein in human lymphocyte cultures. Współcz. Onkol, 16, 332, 2012.
11. Jaszczyszyn A. et al.: Wpływ wysokich stȩżeń flufenazyny na funkcjȩ transportowa̧ glikoproteiny P i na żywotność limfocytów uszkodzonych genotoksycznie in vitro. In: Problemy opieki nad chorym przewlekle. Uchmanowicz I, RosiriczukTonderys J. (eds). MedPharm Polska, 347. Wrocław 2012.
12. Li H. et al.: Using rhodamine 123 accumulation in CD8+ cells as a surrogate indicator to study the P-glycoprotein modulating effect cepharanthine hydrochloride in vivo. J. Biomed. Biotechnol., 281651, 2011.
13. Michalak K. et al.: Lipid membrane perturbation caused by some isoflavones and phenothiazines, and the activity of these compounds as inhibitors of multidrug resistance. Cell. Mol. Biol. Lett., 7, 293, 2002.
14. Rothnic A. et al.: The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence. Eur. Biophys. J., 30, 430, 2001.