Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome P450-activated prodrugs

Molecular Pharmaceutics

Volumn 10, Issue 2, 2013, Pages 532-537

  Huttunen, Kristiina M ^a   Tani, Niina ^a   Juvonen, Risto O ^a   Raunio, Hannu ^a   Rautio, Jarkko ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

5 aminosalicylic acid; bioactivation bioconversion; cyclic phosphate; cytochrome P450 enzyme; prodrug

Indexed keywords

5 AMINO 2 ((2 OXIDO 4 PHENYL 1,3,2 DIOXAPHOSPHINAN 2 YL)OXY)BENZOIC ACID; 5 AMINO 2 ((4 (2 CHLOROPHENYL) 2 OXIDO 1,3,2 DIOXAPHOSPHINAN 2 YL)OXY)BENZOIC ACID; 5 AMINO 2 ((4 (3 CHLOROPHENYL) 2 OXIDO 1,3,2 DIOXAPHOSPHINAN 2 YL)OXY)BENZOIC ACID; 5 AMINO 2 ((4 (4 CHLOROPHENYL) 2 OXIDO 1,3,2 DIOXAPHOSPHINAN 2 YL)OXY)BENZOIC ACID; AMINOSALICYLIC ACID; CYTOCHROME P450; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVATION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; RAT;

CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; MAGNETIC RESONANCE SPECTROSCOPY; MESALAMINE; MOLECULAR STRUCTURE; PRODRUGS;

EID: 84873326782     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300330v     Document Type: Article

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