Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease

EMBO Molecular Medicine

Volumn 5, Issue 2, 2013, Pages 210-220

  Kentsis, Alex ^a   Shulman, Andrew ^a   Ahmed, Saima ^a   Brennan, Eileen ^a   Monuteaux, Michael C ^a   Lee, Young Ho ^b   Lipsett, Susan ^a   Paulo, Joao A ^a   Dedeoglu, Fatma ^a   Fuhlbrigge, Robert ^a   Bachur, Richard ^a   Bradwin, Gary ^a   Arditi, Moshe ^b   Sundel, Robert P ^a   Newburger, Jane W ^a   Steen, Hanno ^a   Kim, Susan ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Biomarker; Kawasaki disease; Mass spectrometry; Urinary proteome; Vasculitis

Indexed keywords

ACETYLSALICYLIC ACID; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CYTOKINE; DESMOGLEIN 2; FILAMIN C; IMMUNOGLOBULIN; INTERLEUKIN 6 RECEPTOR; MEPRIN; OBSCURIN; TALIN; THROMBOMODULIN; UNCLASSIFIED DRUG;

ARTHRITIS; ARTICLE; CHILD; CYTOMEGALOVIRUS INFECTION; DIAGNOSTIC ACCURACY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; LYME DISEASE; MAJOR CLINICAL STUDY; MALE; MOUSE; MUCOCUTANEOUS LYMPH NODE SYNDROME; NONHUMAN; OTITIS MEDIA; PNEUMONIA; POSTVIRAL FATIGUE SYNDROME; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEOMICS; PYELONEPHRITIS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; SERUM SICKNESS; STREPTOCOCCAL PHARYNGITIS; URINALYSIS;

ANIMALS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CONTRACTILE PROTEINS; FEMALE; HUMANS; INFANT; MALE; MASS SPECTROMETRY; METALLOENDOPEPTIDASES; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; MUCOCUTANEOUS LYMPH NODE SYNDROME; PROTEOMICS;

EID: 84873324800     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201201494     Document Type: Article

References (45)

1. Adachi J, Kumar C, Zhang Y, Olsen JV, Mann M (2006) The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol 7: R80.
2. Baker AL, Lu M, Minich LL, Atz AM, Klein GL, Korsin R, Lambert L, Li JS, Mason W, Radojewski E, et al (2009) Associated symptoms in the ten days before diagnosis of Kawasaki disease. J Pediatr 154: 592- 595, e592.
3. Bangert I, Tumulka F, Abele R (2011) The lysosomal polypeptide transporter TAPL: more than a housekeeping factor? Biol Chem 392: 61-66.
4. Bond JS, Matters GL, Banerjee S, Dusheck RE (2005) Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer. FEBS Lett 579: 3317-3322.
5. Bonnemann CG, Thompson TG, van der Ven PF, Goebel HH, Warlo I, Vollmers B, Reimann J, Herms J, Gautel M, Takada F, et al (2003) Filamin C accumulation is a strong but nonspecific immunohistochemical marker of core formation in muscle. J Neurol Sci 206: 71-78.
6. Burns JC, Mason WH, Glode MP, Shulman ST, Melish ME, Meissner C, Bastian J, Beiser AS, Meyerson HM, Newburger JW (1991) Clinical and epidemiologic characteristics of patients referred for evaluation of possible Kawasaki disease. United States Multicenter Kawasaki Disease Study Group. J Pediatr 118: 680-686.
7. Checchia PA, Borensztajn J, Shulman ST (2001) Circulating cardiac troponin I levels in Kawasaki disease. Pediatr Cardiol 22: 102-106.
8. Choi H, Fermin D, Nesvizhskii AI (2008) Significance analysis of spectral count data in label-free shotgun proteomics. Mol Cell Proteomics 7: 2373-2385.
9. Chow YM, Lin CY, Hwang B (1993) Serum and urinary interleukin-6 (IL-6) levels as predicting factors of Kawasaki disease activity. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 34: 77-83.
10. Dedeoglu F, Sundel RP (2007) Vasculitis in children. Rheum Dis Clin North Am 33: 555-583.
11. Ebata R, Abe J, Yasukawa K, Hamada H, Higashi K, Suwazono Y, Saito H, Terai M, Kohno Y (2011) Increased production of vascular endothelial growth factor-d and lymphangiogenesis in acute Kawasaki disease. Circ J 75: 1455-1462.
12. Ebihara T, Endo R, Kikuta H, Ishiguro N, Ma X, Shimazu M, Otoguro T, Kobayashi K (2005) Differential gene expression of S100 protein family in leukocytes from patients with Kawasaki disease. Eur J Pediatr 164: 427-431.
13. Elias JE, Gygi SP (2007) Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat Methods 4: 207-214.
14. Gedalia A (2007) Kawasaki disease: 40 years after the original report. Curr Rheumatol Rep 9: 336-341.
15. Herzog C, Kaushal GP, Haun RS (2005) Generation of biologically active interleukin-1beta by meprin B. Cytokine 31: 394-403.
16. Huang MY, Gupta-Malhotra M, Huang JJ, Syu FK, Huang TY (2010) Acute-phase reactants and a supplemental diagnostic aid for Kawasaki disease. Pediatr Cardiol 31: 1209-1213.
17. Kaneko K, Yoshimura K, Ohashi A, Kimata T, Shimo T, Tsuji S (2011) Prediction of the risk of coronary arterial lesions in Kawasaki disease by brain natriuretic peptide. Pediatr Cardiol 32: 1106-1109.
18. Kentsis A (2011) Challenges and opportunities for discovery of disease biomarkers using urine proteomics. Pediatr Int 53: 1-6.
19. Kentsis A, Lin YY, Kurek K, Colicchio M, Wang YY, Monigatti F, Campagne F, Lee RS, Horwitz BH, Steen H, et al (2010) Discovery and validation of urine markers of acute pediatric appendicitis using high accuracy mass spectrometry. Ann Emerg Med 55: 62-70.
20. Kentsis A, Monigatti F, Dorff K, Campagne F, Bachur RG, Steen H (2009) Urine proteomics for profiling of human disease using high accuracy mass spectrometry. Proteomics Clin Appl 3: 1052-1061.
21. Lehman TJ, Warren R, Gietl D, Mahnovski V, Prescott M (1988) Variable expression of Lactobacillus casei cell wall-induced coronary arteritis: an animal model of Kawasaki's disease in selected inbred mouse strains. Clin Immunol Immunopathol 48: 108-118.
22. Lin CY, Lin CC, Hwang B, Chiang B (1992) Serial changes of serum interleukin-6, interleukin-8, and tumor necrosis factor alpha among patients with Kawasaki disease. J Pediatr 121: 924-926.
23. Ling XB, Lau K, Kanegaye JT, Pan Z, Peng S, Ji J, Liu G, Sato Y, Yu TT, Whitin JC, et al (2011) A diagnostic algorithm combining clinical and molecular data distinguishes Kawasaki disease from other febrile illnesses. BMC Med 9: 130.
24. Madsen J, Mollenhauer J, Holmskov U (2010) Review: Gp-340/DMBT1 in mucosal innate immunity. Innate Immun 16: 160-167.
25. McCrindle BW, Li JS, Minich LL, Colan SD, Atz AM, Takahashi M, Vetter VL, Gersony WM, Mitchell PD, Newburger JW (2007) Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements. Circulation 116: 174-179.
26. Nakamura Y, Yashiro M, Uehara R, Sadakane A, Chihara I, Aoyama Y, Kotani K, Yanagawa H (2010) Epidemiologic features of Kawasaki disease in Japan: results of the 2007-2008 nationwide survey. J Epidemiol 20: 302-307.
27. Newburger JW, Sleeper LA, McCrindle BW, Minich LL, Gersony W, Vetter VL, Atz AM, Li JS, Takahashi M, Baker AL, et al (2007) Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease. N Engl J Med 356: 663-675.
28. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, Shulman ST, Bolger AF, Ferrieri P, Baltimore RS, et al (2004) Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 110: 2747-2771.
29. Oetting WS, Rogers TB, Krick TP, Matas AJ, Ibrahim HN (2006) Urinary beta2-microglobulin is associated with acute renal allograft rejection. Am J Kidney Dis 47: 898-904.
30. Peng Q, Wu Q, Chen CH, Hong H, Zhang LY (2006) Value of serum soluble interleukin-2R, interleukin-6 and C-reactive protein in the early diagnosis of Kawasaki disease. Zhongguo Dang Dai Er Ke Za Zhi 8: 208-210.
31. Pisitkun T, Johnstone R, Knepper MA (2006) Discovery of urinary biomarkers. Mol Cell Proteomics 5: 1760-1771.
32. Rai AJ, Stemmer PM, Zhang Z, Adam BL, Morgan WT, Caffrey RE, Podust VN, Patel M, Lim LY, Shipulina NV, et al (2005) Analysis of Human Proteome Organization Plasma Proteome Project (HUPO PPP) reference specimens using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry: multi-institution correlation of spectra and identification of biomarkers. Proteomics 5: 3467-3474.
33. Rowley AH, Baker SC, Orenstein JM, Shulman ST (2008) Searching for the cause of Kawasaki disease - cytoplasmic inclusion bodies provide new insight. Nat Rev Microbiol 6: 394-401.
34. Sato YZ, Molkara DP, Daniels LB, Tremoulet AH, Shimizu C, Kanegaye JT, Best BM, Snider JV, Frazer JR, Maisel A, et al (2011) Cardiovascular biomarkers in acute Kawasaki disease. Int J Cardiol, DOI: 10.1016/j.ijcard.2011.06.065.
35. Schulte DJ, Yilmaz A, Shimada K, Fishbein MC, Lowe EL, Chen S, Wong M, Doherty TM, Lehman T, Crother TR, et al (2009) Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease. J Immunol 183: 5311-5318.
36. Simonini G, Masi L, Giani T, Piscitelli E, Cimaz R, Vierucci S, Brandi ML, Falcini F (2005) Osteoprotegerin serum levels in Kawasaki disease: an additional potential marker in predicting children with coronary artery involvement. J Rheumatol 32: 2233-2238.
37. Suda K, Iemura M, Nishiono H, Teramachi Y, Koteda Y, Kishimoto S, Kudo Y, Itoh S, Ishii H, Ueno T, et al (2011) Long-term prognosis of patients with Kawasaki disease complicated by giant coronary aneurysms: a single-institution experience. Circulation 123: 1836-1842.
38. Suganami Y, Kawashima H, Hasegawa D, Sato S, Hoshika A (2008) Clinical application of rapid assay of serum interleukin-6 in Kawasaki disease. Pediatr Int 50: 264-266.
39. Taubert KA, Rowley AH, Shulman ST (1991) Nationwide survey of Kawasaki disease and acute rheumatic fever. J Pediatr 119: 279-282.
40. Weng KP, Hsieh KS, Ho TY, Huang SH, Lai CR, Chiu YT, Huang SC, Lin CC, Hwang YT, Ger LP (2010) IL-1B polymorphism in association with initial intravenous immunoglobulin treatment failure in Taiwanese children with Kawasaki disease. Circ J 74: 544-551.
41. Wilder MS, Palinkas LA, Kao AS, Bastian JF, Turner CL, Burns JC (2007) Delayed diagnosis by physicians contributes to the development of coronary artery aneurysms in children with Kawasaki syndrome. Pediatr Infect Dis J 26: 256-260.
42. Woroniecki RP, Orlova TN, Mendelev N, Shatat IF, Hailpern SM, Kaskel FJ, Goligorsky MS, O'Riordan E (2006) Urinary proteome of steroid-sensitive and steroid-resistant idiopathic nephrotic syndrome of childhood. Am J Nephrol 26: 258-267.
43. Xiu-Yu S, Jia-Yu H, Qiang H, Shu-Hui D (2010) Platelet count and erythrocyte sedimentation rate are good predictors of Kawasaki disease: ROC analysis. J Clin Lab Anal 24: 385-388.
44. Yellen ES, Gauvreau K, Takahashi M, Burns JC, Shulman S, Baker AL, Innocentini N, Zambetti C, Pancheri JM, Ostrow A, et al (2010) Performance of 2004 American Heart Association recommendations for treatment of Kawasaki disease. Pediatrics 125: e234-241.
45. Zimmerli LU, Schiffer E, Zurbig P, Good DM, Kellmann M, Mouls L, Pitt AR, Coon JJ, Schmieder RE, Peter KH, et al (2008) Urinary proteomic biomarkers in coronary artery disease. Mol Cell Proteomics 7: 290-298.