Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats

Free Radical Biology and Medicine

Volumn 55, Issue , 2013, Pages 21-26

  Kara, Adem ^a   Akman, Sumeyra ^a   Ozkanlar, Seckin ^a   Tozoglu, Ummuhan ^b   Kalkan, Yildiray ^c   Canakci, Cenk Fatih ^a   Tozoglu, Sinan ^b  

^a ATATÜRK UNIVERSITY   (Turkey)

^b AKDENIZ UNIVERSITY   (Turkey)

^c RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

Author keywords

Antioxidants; Cytokines; Free radicals; Inflammation; Melatonin; Periodontitis

Indexed keywords

GLUTATHIONE; INTERLEUKIN 1BETA; MELATONIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HISTOLOGY; IMMUNOMODULATION; MALE; MOLAR TOOTH; NONHUMAN; OXIDATIVE STRESS; PERIODONTITIS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; IMMUNOMODULATION; MALE; MELATONIN; PERIODONTITIS; RATS; RATS, WISTAR;

EID: 84873320222     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.11.002     Document Type: Article

References (42)

1. Akman, S.; Canakci, V.; Kara, A.; Tozoglu, U.; Arabaci, T.; Dagsuyu, I.M. Therapeutic effects of alpha-lipoic acid and vitamin C on alveolar bone resorption after experimental periodontitis in rats: a biochemical, histochemical and stereologic study. J. Periodontol., 10.1902/jop.2012.120252, in press
2. I.L. Chapple Role of free radicals and antioxidants in the pathogenesis of the inflammatory periodontal diseases Clin. Mol. Pathol 49 1996 M247 M255
3. J.J. Zambon, H. Reynolds, J.G. Fisher, M. Shlossman, R. Dunford, and R.J. Genco Microbiological and immunological studies of adult periodontitis in patients with noninsulin-dependent diabetes-mellitus J. Periodontol. 59 1988 23 31
4. A. Cutando, J. Aneiros-Fernandez, A. Lopez-Valverde, S. Arias-Santiago, J. Aneiros-Cachaza, and R.J. Reiter A new perspective in oral health: potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity Arch. Oral Biol. 56 2011 944 950
5. M. Battino, P. Bullon, M. Wilson, and H. Newman Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species Crit. Rev. Oral Biol. Med. 10 1999 458 476
6. G. Gomez-Moreno, A. Cutando-Soriano, C. Arana, P. Galindo, J. Bolanos, D. Acuna-Castroviejo, and H.L. Wang Melatonin expression in periodontal disease J. Periodont. Res. 42 2007 536 540
7. A. Gustafsson, and B. Asman Increased release of free oxygen radicals from peripheral neutrophils in adult periodontitis after Fc gamma-receptor stimulation J. Clin. Periodontol 23 1996 38 44
8. R.J. Reiter, D. Melchiorri, E. Sewerynek, B. Poeggeler, L. Barlow-Walden, J. Chuang, G.G. Ortiz, and D. Acuña-Castroviejo A review of the evidence supporting melatonin's role as an antioxidant J. Pineal Res. 18 1995 1 11
9. A. Pilger, and H. Rüdiger 8-Hydroxy-2′-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures Int. Arch. Occup. Environ. Health 80 2006 1 15
10. M. Lodovici, C. Casalini, R. Cariaggi, L. Michelucci, and P. Dolara Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes Free Radic. Biol. Med. 28 2000 13 17
11. V.J. Thannickal, and B.L. Fanburg Reactive oxygen species in cell signaling Am. J. Physiol. Lung Cell Mol. Physiol 279 2000 L1005 L1028
12. J. Nordberg, and E.S.J. Arner Reactive oxygen species, antioxidants, and the mammalian thioredoxin system Free Radic. Biol. Med. 31 2001 1287 1312
13. F. Antunes, L.R.C. Barclay, K.U. Ingold, M. King, J.Q. Norris, J.C. Scaiano, and F.D. Xi On the antioxidant activity of melatonin Free Radic. Biol. Med. 26 1999 117 128
14. A. Cutando, G. Gomez-Moreno, C. Arana, D. Acuna-Castroviejo, and R.J. Reiter Melatonin: potential functions in the oral cavity J. Periodontol. 78 2007 1094 1102
15. R.J. Reiter, and D.X. Tan Role of CSF in the transport of melatonin J. Pineal Res. 33 2002 61-61
16. C. Rodriguez, J.C. Mayo, R.M. Sainz, I. Antolin, F. Herrera, V. Martin, and R.J. Reiter Regulation of antioxidant enzymes: a significant role for melatonin J. Pineal Res. 36 2004 1 9
17. R.J. Reiter Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals Eur. J. Endocrinol 134 1996 412 420
18. M. Allegra, R. Reiter, D.X. Tan, C. Gentile, L. Tesoriere, and M. Livrea The chemistry of melatonin's interaction with reactive species J. Pineal Res. 34 2003 1 10
19. D.P. Cardinali, M.G. Ladizesky, V. Boggio, R.A. Cutrera, and C. Mautalen Melatonin effects on bone: experimental facts and clinical perspectives J. Pineal Res. 34 2003 81 87
20. M. Turgut, Y. Uyanikgil, M. Baka, A.T. Tunc, A. Yavasoglu, M.E. Yurtseven, and S. Kaplan Pinealectomy exaggerates and melatonin treatment suppresses neuroma formation of transected sciatic nerve in rats: gross morphological, histological and stereological analysis J. Pineal Res. 38 2005 284 291
21. M. Battino, S. Bompadre, A. Politi, M. Fioroni, C. Rubini, and P. Bullon Antioxidant status (CoQ 10 and Vit. E levels) and immunohistochemical analysis of soft tissues in periodontal diseases Biofactors 25 2005 213 217
22. B.O. Cetinkaya, G.C. Keles, B. Ayas, E.E. Sakallioglu, and G. Acikgoz The expression of vascular endothelial growth factor in a rat model at destruction and healing stages of periodontal disease J. Periodontol. 78 2007 1129 1135
23. B.O. Cetinkaya, G.C. Keles, B. Ayas, and P. Gurgor Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats J. Periodontol. 79 2008 1950 1961
24. T. Tomofuji, D. Ekuni, T. Sanbe, K. Irie, T. Azuma, T. Maruyama, N. Tamaki, J. Murakami, S. Kokeguchi, and T. Yamamoto Effects of vitamin C intake on gingival oxidative stress in rat periodontitis Free Radic. Biol. Med. 46 2009 163 168
25. N. Simsek, M. Kaya, A. Kara, I. Can, A. Karadeniz, and Y. Kalkan Effects of melatonin on islet neogenesis and beta cell apoptosis in streptozotocin- induced diabetic rats: an immunohistochemical study Domest. Anim. Endocrinol. 43 2012 47 57
26. M. Kanter Protective effects of melatonin on the experimental traumatic brain injury model in rats J. Head Trauma Rehabil 26 2011 429-429
27. M. Kanter, H. Uysal, T. Karaca, and H.O. Sagmanligil Depression of glucose levels and partial restoration of pancreatic beta-cell damage by melatonin in streptozotocin-induced diabetic rats Arch. Toxicol 80 2006 362 369
28. S. Cuzzocrea, B. Zingarelli, P. Hake, A.L. Salzman, and C. Szabo Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation Free Radic. Biol. Med. 24 1998 450 459
29. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal-tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358
30. J. Sedlak, and R.H. Lindsay Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal. Biochem. 25 1968 192
31. E. Kulczykowska, and P.M. Iuvone Highly sensitive and specific assay of plasma melatonin using high-performance liquid chromatography with fluorescence detection preceded by solid-phase extraction J. Chromatogr. Sci 36 1998 175 178
32. C. Susin, and C.K. Rosing Effect of variable moderate chronic stress on ligature-induced periodontal disease in Wistar rats Acta Odontol. Scand 61 2003 273 277
33. D.X. Tan, L.C. Manchester, R.J. Reiter, B.F. Plummer, L.J. Hardies, S.T. Weintraub, and A.M.M. Shepherd A novel melatonin metabolite, cyclic 3-hydroxymelatonin: a biomarker of in vivo hydroxyl radical generation Biochem. Biophys. Res. Commun. 253 1998 614 620
34. H. Tamura, A. Takasaki, I. Miwa, K. Tanoguchi, R. Maekawa, H. Asada, T. Taketani, A. Matsuoka, Y. Yamagata, K. Shimamura, H. Morioka, H. Ishikawa, R.J. Reiter, and N. Sugino Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate J. Pineal Res. 44 2008 280 287
35. G. Ghosh, K. De, S. Maity, D. Bandyopadhyay, S. Bhattacharya, R.J. Reiter, and A. Bandyopadhyay Melatonin protects against oxidative damage and restores expression of GLUT4 gene in the hyperthyroid rat heart J. Pineal Res. 42 2007 71 82
36. M. Guha, P. Maity, V. Choubey, K. Mitra, R.J. Reiter, and U. Bandyopadhyay Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection J. Pineal Res. 43 2007 372 381
37. C.F. Canakci, Y. Cicek, A. Yildirim, U. Sezer, and V. Canakci Increased levels of 8-hydroxydeoxyguanosine and malondialdehyde and its relationship with antioxidant enzymes in saliva of periodontitis patients Eur. J. Dent. 3 2009 100
38. R. Srinath, A.B. Acharya, and S.L. Thakur Salivary and gingival crevicular fluid melatonin in periodontal health and disease J. Periodontol. 81 2010 277 283
39. D.T. Graves The potential role of chemokines and inflammatory cytokines in periodontal disease progression Clin. Infect. Dis 28 1999 482 490
40. E. Sewerynek, D. Melchiorri, L.D. Chen, and R.J. Reiter Melatonin reduces both basal and bacterial lipopolysaccharide-induced lipid peroxidation in vitro Free Radic. Biol. Med. 19 1995 903 909
41. M.I. Cengiz, S. Cengiz, and H.L. Wang Melatonin and oral cavity Int. J. Dent. 2012 2012 491872
42. D. Salvemini, E. Mazzon, L. Dugo, I. Serraino, A. De Sarro, A.P. Caputi, and S. Cuzzocrea Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic Arthritis Rheum. 44 2001 2909 2921