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Bioorganic and Medicinal Chemistry

Volumn 21, Issue 4, 2013, Pages 874-882

Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues

(4) Bhabak, Krishna P a Kleuser, Burkhard b Huwiler, Andrea c Arenz, Christoph a

a HUMBOLDT UNIVERSITY (Germany)

b UNIVERSITY OF POTSDAM (Germany)

c UNIVERSITY OF BERN (Switzerland)

Author keywords

Ceramidase inhibitors; Ceramide; Sphingolipids; Structure activity relationship

Indexed keywords

12 (DIMETHYLAMINO) N (1 HYDROXY 1 PHENYLPROPAN 2 YL)DODECANAMIDE; 12 (DIMETHYLAMINO) N [2 HYDROXY 2 (PYRIDIN 3 YL)ETHYL]DODECANMIDE; 12 (DIMETHYLAMINO) N [2 HYDROXY 2 (PYRIDIN 4 YL)ETHYL]DODECANMIDE; 3 HYDROXY 3 (4 NITROPHENYL) 2 (TETRADECANAMIDO)PROPIONIC ACID; ACID CERAMIDASE; B 13; CERAMIDASE INHIBITOR; CERAMIDE; HYDROLASE INHIBITOR; KBP 102; KBP 105; KBP 93; KBP 94; KBP 99; KPB 49; KPB 67; LCL 464; N [1 (4 AMINOPHENYL) 1,3 DIHYDROXYPROPAN 2 YL]TETRADECANAMIDE; N [3 HYDROXY 1 (4 NITROPHENYL) 1 OXOPROPAN 2 YL]TETRADECANAMIDE; NEUTRAL CERAMIDASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ACID CERAMIDASE; AMIDES; APOPTOSIS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; LAURIC ACIDS; NEUTRAL CERAMIDASE; PROPANOLAMINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873299371 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.12.014 Document Type: Article

Times cited : (30)

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