Hepatocytes determine the hypoxic microenvironment and radiosensitivity of colorectal cancer cells through production of nitric oxide that targets mitochondrial respiration

International Journal of Radiation Oncology Biology Physics

Volumn 85, Issue 3, 2013, Pages 820-827

  Jiang, Heng ^a   Verovski, Valeri N ^a   Leonard, Wim ^a   Law, Ka Lun ^a   Vermeersch, Marieke ^a   Storme, Guy ^a   Van Den Berge, Dirk ^a   Gevaert, Thierry ^a   Sermeus, Alexandra ^a   De Ridder, Mark ^a  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITASE; CELL LINES; CO-CULTURE SYSTEM; CO-CULTURES; COLORECTAL CANCER; COLORECTAL CANCER CELL; CYTOKINES; DIFFUSION LIMITED; ENZYMATIC ACTIVITIES; FLUORESCENCE PROBES; HEPATOCYTES; HYPOXIA-INDUCED RADIORESISTANCE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIVER METASTASIS; MICROENVIRONMENTS; MITOCHONDRIAL INHIBITORS; MITOCHONDRIAL RESPIRATION; OXYGEN LEVELS; OXYGEN-SENSING; RADIO-SENSITIZATION; RADIOPROTECTION; RADIORESISTANCE; REOXYGENATION; REVERSE TRANSCRIPTION; TUMOR CELLS; WESTERN BLOTTING;

CELL CULTURE; DISEASES; ENZYME ACTIVITY; NITRIC OXIDE; OXYGEN; OXYGENATION; TUMORS;

CELLS;

ACONITATE HYDRATASE; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRITE; OXYGEN;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL HYPOXIA; COCULTURE; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; FLUOROMETRY; HUMAN; HUMAN CELL; LIVER CELL; LIVER METASTASIS; MACROPHAGE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN SUPPLY; OXYGENATION; PRIORITY JOURNAL; RADIATION PROTECTION; RADIOSENSITIVITY; REOXYGENATION; RESPIRATORY ARREST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; CELL RESPIRATION; COCULTURE TECHNIQUES; COLORECTAL NEOPLASMS; ENZYME INDUCTION; HCT116 CELLS; HEPATOCYTES; HT29 CELLS; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MACROPHAGES; MICE; MICE, INBRED BALB C; MITOCHONDRIA, LIVER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXYGEN CONSUMPTION; RADIATION TOLERANCE; TUMOR MICROENVIRONMENT;

EID: 84873278515     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.07.2359     Document Type: Article

References (20)

1. J.M. Brown, and A.J. Giaccia The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy Cancer Res 58 1998 1408 1416
2. N. Crokart, B.F. Jordan, and C. Baudelet Glucocorticoids modulate tumor radiation response through a decrease in tumor oxygen consumption Clin Cancer Res 13 2007 630 635
3. M.W. Dewhirst, I.C. Navia, and D.M. Brizel Multiple etiologies of tumor hypoxia require multifaceted solutions Clin Cancer Res 13 2007 375 377
4. C. Diepart, O. Karroum, and J. Magat Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors Cancer Res 72 2012 482 490
5. F. Frérart, P. Sonveaux, and G. Rath The acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide: Towards a new and safe radiosensitizing strategy Clin Cancer Res 14 2008 2768 2774
6. B.F. Jordan, J. Peeterbroeck, and O. Karroum Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms Cancer Lett 293 2010 213 219
7. G.C. Brown Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase Biochim Biophys Acta 1504 2001 46 57
8. J. Stadler, T.R. Billiar, and R.D. Curran Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes Am J Physiol 260 1991 C910 C916
9. J. Hynes, L.D. Marroquin, and V.I. Ogurtsov Investigation of drug-induced mitochondrial toxicity using fluorescence-based oxygen-sensitive probes Toxicol Sci 92 2006 186 200
10. H. Jiang, M. De Ridder, and V.N. Verovski Activated macrophages as a novel determinant of tumor cell radioresponse: The role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing Int J Radiat Oncol Biol Phys 76 2010 1520 1527
11. D.M. Cochran, D. Fukumura, and M. Ancukiewicz Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells Ann Biomed Eng 34 2006 1247 1258
12. A.K. Nussler, M. Di Silvio, and T.R. Billiar Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin J Exp Med 176 1992 261 264
13. L. Wojtczak The Crabtree effect: A new look at the old problem Acta Biochim Pol 43 1996 361 368
14. M.Y. Janssens, D.L. Van den Berge, and V.N. Verovski Activation of inducible nitric oxide synthase results in nitric oxide-mediated radiosensitization of hypoxic EMT-6 tumor cells Cancer Res 58 1998 5646 5648
15. D.L. Van den Berge, M. De Ridder, and V.N. Verovski Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase Br J Cancer 84 2001 1122 1125
16. M. De Ridder, H. Jiang, and G. Van Esch IFN-gamma+ CD8+ T lymphocytes: Possible link between immune and radiation responses in tumor-relevant hypoxia Int J Radiat Oncol Biol Phys 71 2008 647 651
17. M. De Ridder, D. Verellen, and V. Verovski Hypoxic tumor cell radiosensitization through nitric oxide Nitric Oxide 19 2008 164 169
18. N. Meister, T. Shalaby, and A.O. von Bueren Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio- and chemotherapy Eur J Cancer 43 2007 1833 1841
19. R. Neta Modulation of radiation damage by cytokines Stem Cells 15 1997 87 94
20. V.N. Verovski, D.L. Van den Berge, and G.A. Soete Intrinsic radiosensitivity of human pancreatic tumour cells and the radiosensitising potency of the nitric oxide donor sodium nitroprusside Br J Cancer 74 1996 1734 1742