Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 77, Issue , 2013, Pages 21-28

  Yang, Jie ^a   Lv, Fang ^a   Chen, Xiao qing ^b   Cui, Wei xi ^a   Chen, Li hong ^c   Wen, Xiao dong ^a   Wang, Qiang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

I. hainanensis; LC MS; NAFLD; Pharmacokinetics; Rat plasma

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHLOROGENIC ACID; CHOLESTEROL; GLUCOSE DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ILEX HAINANENSIS EXTRACT; KAEMPFEROL 7 O BETA GLUCOSIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ILEX; ILEX HAINANENSIS; LIVER WEIGHT; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL FACTORS; CHLOROGENIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; FATTY LIVER; GLYCOSIDES; ILEX; KAEMPFEROLS; MALE; MEDICINE, CHINESE TRADITIONAL; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRITERPENES;

EID: 84873256840     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.01.011     Document Type: Article

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