High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber

Biomedical Optics Express

Volumn 4, Issue 2, 2013, Pages 260-270

  Papadopoulos, Ioannis N ^a   Farahi, Salma ^a   Moser, Christophe ^a   Psaltis, Demetri ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE; IMAGE RESOLUTION; MEDICAL IMAGING; OPTICAL FIBERS; TISSUE;

CELLULAR PHENOTYPES; COLLECTION EFFICIENCY; DIGITAL SCANNING; ENDOSCOPIC IMAGING; FIELD OF VIEWS; FLUORESCENCE IMAGE; HIGH QUALITY; HIGH QUALITY IMAGES; HIGH RESOLUTION; LASER LIGHTS; MINIMALLY INVASIVE; MULTIMODE OPTICAL FIBERS; NEURONAL CELL; SUBMICRON; TISSUE PENETRATIONS; ULTRA-THIN;

ENDOSCOPY;

EID: 84873248082     PISSN: None     EISSN: 21567085     Source Type: Journal    
DOI: 10.1364/BOE.4.000260     Document Type: Article

References (28)

1. B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber optic fluorescence imaging," Nat. Methods 2, 941-950 (2005).
2. F. Helmchen, "Miniaturization of fluorescence microscopes using fibre optics," Exp. Physiol. 87, 737-745 (2002).
3. J. Jung and M. Schnitzer, "Multiphoton endoscopy," Opt. Lett. 28, 902-904 (2003).
4. J. Jung, A. Mehta, E. Aksay, R. Stepnoski, and M. Schnitzer, "In vivo mammalian brain imaging using one-and two-photon fluorescence microendoscopy," J. Neurophysiol. 92, 3121-3133 (2004).
5. M. J. Levene, D. Dombeck, K. Kasischke, R. Molloy, and W. Webb, "In vivo multiphoton microscopy of deep brain tissue," J. Neurophysiol. 91, 1908-1912 (2004).
6. T. A. Murray and M. J. Levene, "Singlet gradient index lens for deep in vivo multiphoton microscopy," J. Biomed. Opt. 17, 0211061-0211064 (2012).
7. A. F. Gmitro and D. Aziz, "Confocal microscopy through a fiber-optic imaging bundle," Opt. Lett. 18, 565-567 (1993).
8. W. Gobel, J. N. D. Kerr, A. Nimmerjahn, and F. Helmchen, "Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective," Opt. Lett. 29, 2521-2523 (2004).
9. M. T. Myaing, D. J. MacDonald, and X. Li, "Fiber-optic scanning two-photon fluorescence endoscope," Opt. Lett. 31, 1076-1078 (2006).
10. C. J. Engelbrecht, R. S. Johnston, E. J. Seibel, and F. Helmchen, "Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo," Opt. Express 16, 5556 (2008).
11. D. Rivera, C. Brown, D. Ouzounov, I. Pavlova, D. Kobat, W. Webb, and C. Xu, "Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue," Proc. Natl. Acad. Sci. USA 108, 17598-17603 (2011).
12. R. Rokitski and S. Fainman, "Propagation of ultrashort pulses in multimode fiber in space and time," Opt. Express 11, 1497-1502 (2003).
13. R. Di Leonardo and S. Bianchi, "Hologram transmission through multi-mode optical fibers," Opt. Express 19, 247-254 (2011).
14. T. Čižmár and K. Dholakia, "Shaping the light transmission through a multimode optical fibre: complex transformation analysis and applications in biophotonics," Opt. Express 19, 18871-18884 (2011).
15. I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, "Focusing and scanning light through a multimode optical fiber using digital phase conjugation," Opt. Express 20, 10583 (2012).
16. S. Bianchi and R. Di Leonardo, "A multi-mode fiber probe for holographic micromanipulation and microscopy," Lab Chip 12, 635-639 (2012).
17. T. Čižmár and K. Dholakia, "Exploiting multimode waveguides for pure fibre-based imaging," Nat. Commun. 3, 1027 (2012).
18. Y. Choi, C. Yoon, M. Kim, T. Yang, C. Fang-Yen, R. Dasari, K. Lee, and W. Choi, "Scanner-free and wide-field endoscopic imaging by using a single multimode optical fiber," Phys. Rev. Lett. 109, 203901 (2012).
19. E. N. Leith and J. Upatnieks, "Holographic imagery through diffusing media," J. Opt. Soc. Am. 56, 523-523 (1966).
20. H. Kogelnik and K. S. Pennington, "Holographic imaging through a random medium," J. Opt. Soc. Am. 58, 273-274 (1968).
21. G. S. Agarwal, A. T. Friberg, and E. Wolf, "Scattering theory of distortion correction by phase conjugation," J. Opt. Soc. Am. 73, 529-537 (1983).
22. Z. Yaqoob, D. Psaltis, M. S. Feld, and C. Yang, "Optical phase conjugation for turbidity suppression in biological samples," Nat. Photon. 2, 110-115 (2008).
23. S. M. Popoff, G. Lerosey, R. Carminati, M. Fink, A. Boccara, and S. Gigan, "Measuring the transmission matrix in optics: an approach to the study and control of light propagation in disordered media," Phys. Rev. Lett. 104, 100601 (2010).
24. A. A. Yariv, "Three-dimensional pictorial transmission in optical fibers," Appl. Phys. Lett. 28, 88-89 (1976).
25. Y. Tomita, K. Kyuma, R. Yahalom, and A. A. Yariv, "Demonstration of amplitude-distortion correction by modal dispersal and phase conjugation," Opt. Lett. 12, 1020-1022 (1987).
26. I. McMichael, P. Yeh, and P. Beckwith, "Correction of polarization and modal scrambling in multimode fibers by phase conjugation," Opt. Lett. 12, 507-509 (1987).
27. C. Bellanger, A. Brignon, J. Colineau, and J. P. Huignard, "Coherent fiber combining by digital holography," Opt. Lett. 33, 2937-2939 (2008).
28. C. J. R. Sheppard and A. Choudhury, "Image formation in the scanning microscope," J. Mod. Opt. 24, 1051-1073 (1977).