The PE16 (Rv1430) of Mycobacterium tuberculosis Is an Esterase Belonging to Serine Hydrolase Superfamily of Proteins

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Sultana, Rafiya ^a   Vemula, Mani Harika ^a   Banerjee, Sharmishta ^a   Guruprasad, Lalitha ^a  

^a UNIVERSITY OF HYDERABAD   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENYL ACETATE; 4 NITROPHENYL CAPRATE; 4 NITROPHENYL CAPRYLATE; 4 NITROPHENYL ESTER; 4 NITROPHENYL HEXANOATE; 4 NITROPHENYL MYRISTATE; ALANINE; BENZENE DERIVATIVE; BENZYLSULFONYL FLUORIDE; BUTYRIC ACID 4 NITROPHENYL ESTER; ESTERASE; FATTY ACID ESTER; LAURIC ACID 4 NITROPHENYL ESTER; PALMITIC ACID 4 NITROPHENYL ESTER; PROTEIN PE16; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME STABILITY; ESCHERICHIA COLI; EXPRESSION VECTOR; GENOMICS; HYDROLYSIS; IONIC STRENGTH; MOLECULAR CLONING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PE PPE DOMAIN; PH; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN PURIFICATION;

BACTERIAL PROTEINS; BLOTTING, WESTERN; CATALYTIC DOMAIN; CIRCULAR DICHROISM; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; DNA PRIMERS; ESCHERICHIA COLI; ESTERASES; HYDROGEN-ION CONCENTRATION; MULTIGENE FAMILY; MYCOBACTERIUM TUBERCULOSIS; SERINE ENDOPEPTIDASES; TEMPERATURE;

EID: 84873247683     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055320     Document Type: Article

References (49)

1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537-544.
2. Brennan PJ, (2003) Structure, function, and biogenesis of the cell wall of Mycobacterium Tuberculosis. Tuberculosis 83(1-3): 91-97.
3. Adindla S, Guruprasad L, (2003) Sequence analysis corresponding to the PPE and PE Proteins in Mycobacterium tuberculosis and other genomes. J Biosci 28: 169-179.
4. Voskuil MI, Schnappinger D, Rutherford R, Liu Y, (2004) Schoolnik GK (2004) Regulation of the Mycobacterium tuberculosis PE/PPE genes. Tuberculosis (Edinb) 84: 256-262.
5. Banu S, Honore N, Saint-Joanis B, Philpott D, Prevost MC, et al. (2002) Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens? Mol Microbiol 44: 9-19.
6. Brennan M J, Delogu G, (2002) The PE multigene family: a 'molecular mantra' for Mycobacteria. Trends Microbiol 10: 246-249.
7. Delogu G, Brennan MJ, (2001) Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis. Infect Immun 69: 5606-5611.
8. Delogu G, Pusceddu C, Bua A, Fadda G, Brennan MJ, et al. (2004) Rv1818c encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure. Mol Microbiol 52: 725-733.
9. Brennan MJ, Delogu G, Chen Y, Bardarov S, Kriakov J, et al. (2001) Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells. Infect Immun 69: 7326-7333.
10. Choudhary RK, Mukhopadhyay S, Chakhaiyar P, Sharma N, Murthy KJR, et al. (2003) PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B cell response. Infect Immun 71: 6338-6343.
11. Ramakrishnan L, Federspiel NA, Falkow S, (2000) Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Science 288: 1436-1439.
12. Li Y, Miltner E, Wu M, Petrofsky M, Bermudez LE, (2005) A Mycobacterium avium PPE gene is associated with the ability of the bacterium to grow in macrophages and virulence in mice. Cell Microbiol 7: 539-548.
13. Tundup S, Akhter Y, Thiagarajan D, Hasnain SE, (2006) Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co- transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett 580: 1285-1293.
14. Mishra KC, de Chastellier C, Narayana Y, Bifani P, Brown AK, et al. (2008) Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY. Infect Immun 76: 127-140.
15. Deb C, Daniel J, Sirakova TD, Abomoelak B, Dubey VS, et al. (2006) A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis. J Biol Chem 281: 3866-3875.
16. Cascioferro A, Delogu G, Colone M, Sali M, Stringaro A, et al. (2007) PE is a functional domain responsible for protein translocation and localization on mycobacterial cell wall. Mol. Microbiol 66: 1536-1547.
17. Daleke MH, Cascioferro A, de Punder K, Ummels R, Abdallah AM, et al. (2011) Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway. J Biol Chem 286: 19024-19034.
18. Gey van Pittius NC, Sampson SL, Lee H, Kim Y, van Helden PD, et al. (2006) Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. BMC Evol Biol 6: 95.
19. Sultana R, Tanneeru K, Guruprasad L (2011) The PE-PPE domain in mycobacterium reveals a Serine α/β Hydrolase fold and function: an in-silico analysis. PLoS ONE 6, e16745.
20. Bradford M, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
21. Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR, (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77: 51-59.
22. Schue M, Maurin D, Dhouib R, Bakala N'Goma JC, Delorme V, et al. (2010) Two cutinase- like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function. Faseb J 24: 1893-1903.
23. West NP, Chow FM, Randall EJ, Wu J, Chen J, et al. (2009) Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification. Faseb J 23: 1694-1704.
24. Pratt J, Cooley JD, Purdy CW, Straus DC, (2000) Lipase activity from strains of Pasteurella multocida. Curr Microbiol 40: 306-309.
25. Chen S, Tong X, Woodard RW, Du G, Wu J, et al. (2008) Identification and characterization of bacterial cutinase. J Biol Chem 283: 25854-25862.
26. Walton TJ, Kolattukudy PE, (1972) Determination of the structures of cutin monomers by a novel depolymerization procedure and combined gas chromatography and mass spectrometry. Biochemistry 11: 1885-1896.
27. Bohm G, Muhr R, Jaenicke R, (1992) Quantitative analysis of protein far UV circular dichroism spectra by neural networks. Protein Eng 5: 191-195.
28. Pencreach G, Baratti JC, (1996) Hydrolysis of p-nitrophenyl palmitate in n-heptane by the Pseudomonas cepacia lipase: a simple test for the determination of lipase activity in organic Media. Enzyme Microb Technol 18: 417-422.
29. López-López S, Nolasco H, Vega Villasante F, (2003) Characterization of digestive gland esterase lipase activity of juvenile redclaw crayfish Cherax quadricarinatus. Comp Biochem Physiol B 135: 337-347.
30. Strong M, Sawaya MR, Wang S, Phillips M, Cascio D, et al. (2006) Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 103(21): 8060-8065.
31. Choudhary RK, Pullakhandam R, Ehtesham NZ, Hasnain SE (2004) Expression and characterization of Rv2430c, a novel immunodominant antigen of Mycobacterium tuberculosis. Protein Expr Purif 36, 249-253.
32. Okkels LM, Brock I, Follmann F, Agger EM, Arend SM, et al. (2003) PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family. Infect Immun 71: 6116-6123.
33. Chaitra MG, Shaila MS, Nayak R, (2008) Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis. J Med Microbiol 57: 1079-1086.
34. Guo JB, Zheng XD, Xu LP, Liu ZY, Xu KH, et al. (2010) Characterization of a Novel Esterase Rv0045c from Mycobacterium tuberculosis. PLoS ONE 5: e13143.
35. Snel B, Bork P, Huynen M, (2000) Genome evolution. Gene fusion versus gene fission. Trends in Genetics 16: 9-11.
36. World Health Organization (WHO) (2006) Global and regional incidence. Tuberculosis Fact sheet No 104. WHO, Mar 2006. http://www.who.int/mediacentre/factsheets/fs104/- en/inde-x.html. Accessed 6 Oct 2006.
37. Daffe M, Draper P, (1998) The envelope layers of mycobacteria with reference to their pathogenicity. Adv Microb Physiol 39: 131-203.
38. Minnikin DE, Kremer L, Dove LG, Besra GS, (2002) The Methyl-Branched fortifications of Mycobacterium tuberculosis. Chem Biol 9: 545-553.
39. Kremer L, de Chastellier C, Dobson G, Gibson KJ, Bifani P, et al. (2005) Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol. Mol Microbiol 57: 1113-1126.
40. Garton NJ, Christensen H, Minnikin DE, Adegbola RA, Barer MR, (2002) Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum. Microbiol 148: 2951-2958.
41. Neyrolles O, Herna'ndez-Pando R, Pietri-Rouxel F, Forne's P, Tailleux L, et al. (2006) Is adipose tissue a place for Mycobacterium tuberculosis persistence? PLoS ONE 1: 43.
42. Daniel J, Deb C, Dubey VS, Sirakova TD, Abomoelak B, et al. (2004) Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture. J Bacteriol 186: 5017-5030.
43. Cotes K, Dhouib R, Douchet I, Chahinian H, de Caro A, et al. (2007) Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids. Biochem J 408: 417-427.
44. Barry CE 3rd (2001) Interpreting cell wall 'virulence factors' of Mycobacterium tuberculosis. Trends Microbiol 9: 237-241.
45. Kusner DJ, (2005) Mechanisms of mycobacterial persistence in tuberculosis. Clin Immunol 114: 239-247.
46. McKinney JD, Honer zu Bentrup K, Munoz-Elias EJ, Miczak A, Chen B, et al. (2000) Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 406: 735-738.
47. Parker SK, Barkley RM, Rino JG, Vasil ML, (2009) Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin. PLoS ONE 4(1): e4281.
48. Sassetti CM, Boyd DH, Rubin EJ, (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48: 77-84.
49. Lamichhane G, Zignol M, Blades NJ, Geiman DE, Dougherty A, et al. (2003) Apostgenomic method for predicting essential genes at subsaturation levels of mutagenesis: Application to Mycobacterium tuberculosis. Proc Natl Acad Sci USA 100: 7213-7218.