Resveratrol inhibits proliferation of primary rat hepatocytes in G0/G1 by inhibiting DNA synthesis

Folia Biologica (Czech Republic)

Volumn 58, Issue 4, 2012, Pages 166-172

  Rubiolo, J A ^a   Lopez Alonso H ^a   Martin Vazquez V ^a   Fol Rodriguez N M ^a   Vieytes, M R ^a   Botana, L M ^a   Vega, F V ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Cell cycle inhibition; Epidermal growth factor; Primary and transformed hepatocytes; Proliferation inhibition; Resveratrol

Indexed keywords

BROXURIDINE; RESVERATROL; ANTIOXIDANT; DNA; STILBENE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL CULTURE; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOSE RESPONSE; DRUG EFFECT; G1 PHASE CELL CYCLE CHECKPOINT; LIVER CELL; M PHASE CELL CYCLE CHECKPOINT; NONHUMAN; S PHASE CELL CYCLE CHECKPOINT; ANIMAL; BIOSYNTHESIS; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DIVISION; CELL LINE; HUMAN; PHYSIOLOGY; RAT;

ANIMALS; ANTIOXIDANTS; CELL DIVISION; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELLS, CULTURED; DNA; G0 PHASE; G1 PHASE; G2 PHASE; HEPATOCYTES; HUMANS; RATS; STILBENES;

EID: 84873185315     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Ahmad, N., Adhami, V. M., Afaq, F., Feyes, D. K., Mukhtar, H. (2001) Resveratrol causes WAF-l/p21-mediated G (1) - phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin. Cancer Res. 7, 1466-1473.
2. Alfert, M., Geschwind, I. L. (1958) The development of polysomaty in rat liver. Exp. Cell Res. 15, 230-232.
3. Berry, M., Friend, D. (1969) High-yield preparation of isolated rat liver parenchymal cells. J. Cell. Biol. 43, 506-520.
4. Bertelli, A., Bertelli, A. A., Gozzini, A., Giovannini, L. (1998) Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp. Clin. Res. 24, 133-138.
5. Bertelli, A. A., Giovannini, L., Stradi, R., Bertelli, A., Tillement, J. P. (1996) Plasma, urine and tissue levels of trans-and cis-resveratrol (3, 4', 5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Int. J. Tissue React. 18, 67-71.
6. Bohm, N., Noltemeyer, N. (1981) Development of binuclearity and DNA-polyploidization in the growing mouse liver. Histochemistry. 72, 55-61.
7. Brodsky, W. Y., Uryvaeva, I. V. (1977) Cell polyploidy: its relation to tissue growth and function. Int. Rev. Cytol. 50, 275-332.
8. Bronstad, G. O., Sand, T. E., Christoffersen, T. (1983) Bidirectional concentration-dependent effects of glucagon and dibutyryl cyclic AMP on DNA synthesis in cultured adult rat hepatocytes. Biochim. Biophys. Acta 763, 58-63.
9. Delmas, D., Passilly-Degrace, P., Jannin, B., Cherkaoui Malki, M., Latruffe, N. (2002) Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells. Int. J. Mol. Med. 10, 193-199.
10. Dong, Z. (2003) Molecular mechanism of the chemopreventive effect of resveratrol. Mutat. Res. 523-524, 145-150.
11. Eckl, P. M. (1993) Occurrence and possible consequences of multipolar mitoses in primary cultures of adult rat hepatocytes. J. Cell. Physiol. 154, 601-607.
12. El-Mowafy, A. M., Alkhalaf, M. (2003) Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis 24, 869-873.
13. Epstein, C. J. (1967) Cell size, nuclear content, and the development of polyploidy in the mammalian liver. Proc. Natl. Acad. Sci. USA 57, 327-334.
14. Estrov, Z., Shishodia, S., Faderl, S., Harris, D., Van, Q., Kantarjian, H. M., Talpaz, M., Aggarwal, B. B. (2003) Resveratrol blocks interleukin-1 β-induced activation of the nuclear transcription factor NF-κB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102, 987-995.
15. Fausto, N., Campbell, J. S. (2003) The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech. Dev. 120, 117-130.
16. Fremont, L. (2000) Biological effects of resveratrol. Life Sci. 66, 663-673.
17. Gautam, S. C., Xu, Y. X., Dumaguin, M., Janakiraman, N., Chapman, R. A. (2000) Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging. Bone Marrow Transplant. 25, 639-645.
18. Gosslau, A., Chen, M., Ho, C. T., Chen, K. Y. (2005) A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts. Br. J. Cancer 92, 513-521.
19. Gusman, J., Malonne, H., Atassi, G. (2001) A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis 22, 1111-1117.
20. Hsieh, T. C., Wu, J. M. (1999) Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines. Exp. Cell. Res. 249, 109-115.
21. Huang, C., Ma, W. Y, Goranson, A., Dong, Z. (1999) Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis 20, 237-242.
22. Ignatowicz, E., Baer-Dubowska, W. (2001) Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol. J. Pharmacol. 53, 557-569.
23. Kasdallah-Grissa, A., Mornagui, B., Aouani, E., Hammami, M., El May, M., Gharbi, N., Kamoun, A., El-Fazaa, S. (2007) Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver. Life Sci. 80, 1033-1039.
24. Kuhnle, G., Spencer, J. R, Chowrimootoo, G., Schroeter, H., Debnam, E. S., Srai, S. K., Rice-Evans, C., Hahn, U. (2000) Resveratrol is absorbed in the small intestine as resveratrol glucuronide. Biochem. Biophys. Res. Commun. 272, 212-217.
25. Lancon, A., Delmas, D., Osman, H., Thenot, J. R, Jannin, B., Latruffe, N. (2004) Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process. Biochem. Biophys. Res. Commun. 316, 1132-1137.
26. Liang, Y C., Tsai, S. H., Chen, L., Lin-Shiau, S. Y, Lin, J. K. (2003) Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. Biochem. Pharmacol. 65, 1053-1060.
27. Liontas, A., Yeger, H. (2004) Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Anticancer Res. 24, 987-998.
28. Lu, J., Ho, C. H., Ghai, G., Chen, K. Y (2001) Resveratrol analog, 3, 4, 5, 4'-tetrahydroxystilbene, differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts. Carcinogenesis 22, 321-328.
29. Mgbonyebi, O. P., Russo, J., Russo, I. H. (1998) Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int. J. Oncol. 12, 865-869.
30. Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., Kim, M. K., Beaven, M. A., Burgin, A. B., Manganiello, V., Chung, J. H. (2012) Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-433.
31. Ragione, F. D., Cucciolla, V., Bordello, A., Pietra, V. D., Racioppi, L., Soldati, G., Manna, C., Galletti, P., Zappia, V. (1998) Resveratrol arrests the cell division cycle at S/G2 phase transition. Biochem. Biophys. Res. Commun. 250, 53-58.
32. Refsnes, M., Thoresen, G. H., Sandnes, D., Dajani, O. F., Dajani, L., Christoffersen, T. (1992) Stimulatory and inhibitory effects of catecholamines on DNA synthesis in primary rat hepatocyte cultures: role of α1 - and β-adrenergic mechanisms. J. Cell. Physiol. 151, 164-171.
33. Rubiolo, J. A., Mithieux, G., Vega, F. V (2008) Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur. J. Pharmacol. 591, 66-72.
34. Rubiolo, J. A., Vega, F. V. (2008) Resveratrol protects primary rat hepatocytes against necrosis induced by reactive oxygen species. Biomed. Pharmacother. 62, 606-612.
35. Sale, S., Verschoyle, R. D., Boocock, D., Jones, D. J., Wilsher, N., Ruparelia, K. C., Potter, G. A., Farmer, P. B., Steward, W. P., Gescher, A. J. (2004) Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3, 4, 5, 4'-tetramethoxystilbene. Br. J. Cancer 90, 736-744.
36. Seglen, P. O. (1976) Preparation of isolated rat liver cells. Methods Cell. Biol. 13, 29-83.
37. Severin, E., Willers, R., Bettecken, T. (1984) Flow cytometric analysis of mouse hepatocyte ploidy. II. The development of polyploidy pattern in four mice strains with different life spans. Cell Tissue Res. 238, 649-652.
38. Signorelli, P., Ghidoni, R. (2005) Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J. Nutr. Biochem. 16, 449-466.
39. Styles, J. A., Kelly, M., Pritchard, N. R., Elcombe, C. R. (1988) A species comparison of acute hyperplasia induced by the peroxisome proliferator methylclofenapate: involvement of the binucleated hepatocyte. Carcinogenesis 9, 1647-1655.
40. Vintermyr, O. K., Mellgren, G., Boe, R., Doskeland, S. O. (1989) Cyclic adenosine monophosphate acts synergistically with dexamethasone to inhibit the entrance of cultured adult rat hepatocytes into S-phase: with a note on the use of nucleolar and extranucleolar [3H]-thymidine labelling patterns to determine rapid changes in the rate of onset of DNA replication. J. Cell. Physiol. 141, 371-382.
41. Vitrac, X., Desmouliere, A., Brouillaud, B., Krisa, S., Deffieux, G., Barthe, N., Rosenbaum, J., Merillon, J. M. (2003) Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sci. 72, 2219-2233.
42. Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., Jr., Walle, U. K. (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 32, 1377-1382.
43. Walle, T., Walle, U. K., Sedmera, D., Klausner, M. (2006) Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue. Drug Metab. Dispos. 34, 346-350.
44. Wallerath, T., Deckert, G., Ternes, T., Anderson, H., Li, H., Witte, K., Forstermann, U. (2002) Resveratrol, a polyphenols phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106, 1652-1658.
45. Wheatley, D. N. (1972) Binucleation in mammalian liver. Studies on the control of cytokinesis in vivo. Exp. Cell. Res. 74, 455-465.
46. Yu, C., Shin, Y. G., Chow, A., Li, Y., Kosmeder, J. W., Lee, Y S., Hirschelman, W. H., Pezzuto, J. M., Mehta, R. G., van Breemen, R. B. (2002) Human, rat, and mouse metabolism of resveratrol. Pharm. Res. 19, 1907-1914.