Cryptococcus gattii Induces a Cytokine Pattern That Is Distinct from Other Cryptococcal Species

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Schoffelen, Teske ^a   Illnait Zaragozi, Maria Teresa ^b   Joosten, Leo A B ^a   Netea, Mihai G ^a   Boekhout, Teun ^c,d   Meis, Jacques F ^e   Sprong, Tom ^a,e  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUTO DE MEDICINA TROPICAL PEDRO KOURÍ   (Cuba)

^c CBS KNAW FUNGAL BIODIVERSITY CENTRE   (Netherlands)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

^e CANISIUS WILHELMINA HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS GATTII; CRYPTOCOCCUS NEOFORMANS; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; FUNGAL STRAIN; FUNGUS ISOLATION; HOST RESISTANCE; HUMAN; HUMAN CELL; INNATE IMMUNITY; NONHUMAN; PROTEIN FUNCTION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; SPECIES COMPARISON; TH17 CELL; UPREGULATION;

CRYPTOCOCCUS; CRYPTOCOCCUS GATTII; CYTOKINES; HUMANS; LEUKOCYTES, MONONUCLEAR; RECEPTORS, PATTERN RECOGNITION; SPECIES SPECIFICITY; TOLL-LIKE RECEPTORS;

EID: 84873182892     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055579     Document Type: Article

References (29)

1. Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, et al. (2009) Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23: 525-530.
2. Speed B, Dunt D, (1995) Clinical and host differences between infections with the two varieties of Cryptococcus neoformans. Clin Infect Dis 21: 28-34 discussion 35-26.
3. Chayakulkeeree M, Perfect JR, (2006) Cryptococcosis. Infect Dis Clin North Am 20: 507-544, v-vi.
4. Byrnes EJ, Li W, Lewit Y, Ma H, Voelz K, et al. (2010) Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. PLoS Pathog 6: e1000850.
5. Chaturvedi V, Chaturvedi S, (2011) Cryptococcus gattii: a resurgent fungal pathogen. Trends Microbiol 19: 564-571.
6. Kidd SE, Hagen F, Tscharke RL, Huynh M, Bartlett KH, et al. (2004) A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc Natl Acad Sci U S A 101: 17258-17263.
7. Eyerich S, Eyerich K, Cavani A, Schmidt-Weber C, (2010) IL-17 and IL-22: siblings, not twins. Trends Immunol 31: 354-361.
8. van de Veerdonk F, Gresnigt M, Kullberg B, van der Meer J, Joosten L, et al. (2009) Th17 responses and host defense against microorganisms: an overview. BMB Rep 42: 776-787.
9. van de Veerdonk FL, Kullberg BJ, Netea MG, (2010) Pathogenesis of invasive candidiasis. Curr Opin Crit Care 16: 453-459.
10. Eyerich K, Foerster S, Rombold S, Seidl HP, Behrendt H, et al. (2008) Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22. J Invest Dermatol 128: 2640-2645.
11. Yauch LE, Mansour MK, Shoham S, Rottman JB, Levitz SM, (2004) Involvement of CD14, toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo. Infect Immun 72: 5373-5382.
12. Biondo C, Midiri A, Messina L, Tomasello F, Garufi G, et al. (2005) MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans. Eur J Immunol 35: 870-878.
13. Nakamura K, Miyagi K, Koguchi Y, Kinjo Y, Uezu K, et al. (2006) Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans. FEMS Immunol Med Microbiol 47: 148-154.
14. Nakamura K, Miyazato A, Xiao G, Hatta M, Inden K, et al. (2008) Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway. J Immunol 180: 4067-4074.
15. Shoham S, Huang C, Chen JM, Golenbock DT, Levitz SM, (2001) Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule. J Immunol 166: 4620-4626.
16. Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H, (2009) Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol 10: 864-871.
17. Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, et al. (2009) Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 119: 3573-3585.
18. Ngamskulrungroj P, Chang Y, Sionov E, Kwon-Chung KJ, (2012) The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model. MBio 3.
19. Ma H, Hagen F, Stekel DJ, Johnston SA, Sionov E, et al. (2009) The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation. Proc Natl Acad Sci U S A 106: 12980-12985.
20. Brown GD, Netea MG, SpringerLink (Online service) (2007) Immunology of Fungal Infections. Dordrecht: Springer.
21. Levitz SM, Farrell TP, Maziarz RT, (1991) Killing of Cryptococcus neoformans by human peripheral blood mononuclear cells stimulated in culture. J Infect Dis 163: 1108-1113.
22. Siddiqui AA, Shattock RJ, Harrison TS, (2006) Role of capsule and interleukin-6 in long-term immune control of Cryptococcus neoformans infection by specifically activated human peripheral blood mononuclear cells. Infect Immun 74: 5302-5310.
23. Mody CH, Syme RM, (1993) Effect of polysaccharide capsule and methods of preparation on human lymphocyte proliferation in response to Cryptococcus neoformans. Infect Immun 61: 464-469.
24. Doering TL, (2009) How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans. Annu Rev Microbiol 63: 223-247.
25. van de Veerdonk F, Kullberg B, van der Meer J, Gow N, Netea M, (2008) Host-microbe interactions: innate pattern recognition of fungal pathogens. Curr Opin Microbiol 11: 305-312.
26. Kasperkovitz PV, Khan NS, Tam JM, Mansour MK, Davids PJ, et al. (2011) Toll-like receptor 9 modulates macrophage antifungal effector function during innate recognition of Candida albicans and Saccharomyces cerevisiae. Infect Immun 79: 4858-4867.
27. Popa C, Abdollahi-Roodsaz S, Joosten LA, Takahashi N, Sprong T, et al. (2007) Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4. Infect Immun 75: 4831-4837.
28. Stunz LL, Lenert P, Peckham D, Yi AK, Haxhinasto S, et al. (2002) Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells. Eur J Immunol 32: 1212-1222.
29. Illnait-Zaragozi MT, Martínez-Machín GF, Fernández-Andreu CM, Boekhout T, Meis JF, et al. (2010) Microsatellite typing of clinical and environmental Cryptococcus neoformans var. grubii isolates from Cuba shows multiple genetic lineages. PLoS One 5: e9124.