Neonatal sepsis: A continuing disease burden

Turkish Journal of Pediatrics

Volumn 54, Issue 5, 2012, Pages 449-457

  Satar, Mehmet ^a   Özlü, Ferda ^a  

^a CUKUROVA UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Age at onset; Neonatal; Neonatal intensive care unit; Sepsis

Indexed keywords

ADRENALIN; AMINOGLYCOSIDE; AMPICILLIN; C REACTIVE PROTEIN; CATECHOLAMINE; CD64 ANTIGEN; DOPAMINE; GAMMA INTERFERON; GLUCOCORTICOID; HYDROCORTISONE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INOTROPIC AGENT; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE BINDING PROTEIN; MILRINONE; NORADRENALIN; PENTOXIFYLLINE; PROCALCITONIN; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA; VASOPRESSIN;

ACINETOBACTER; ALPHA HEMOLYTIC STREPTOCOCCUS; CANDIDA ALBICANS; CAUSE OF DEATH; CLINICAL FEATURE; COAGULASE NEGATIVE STAPHYLOCOCCUS; COHORT ANALYSIS; DEVELOPING COUNTRY; DRUG DOSE ESCALATION; ERYTHROCYTE SEDIMENTATION RATE; ESCHERICHIA COLI; HUMAN; HYPOTENSION; INCIDENCE; INFECTION RISK; LABORATORY TEST; MICROORGANISM; NEWBORN; NEWBORN DEATH; NEWBORN INTENSIVE CARE; NEWBORN MORBIDITY; NEWBORN MORTALITY; NEWBORN SEPSIS; PATHOGENESIS; PERINATAL ASPHYXIA; PREMATURE FETUS MEMBRANE RUPTURE; PSEUDOMONAS; RETROSPECTIVE STUDY; REVIEW; RISK FACTOR; SEPTIC SHOCK; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS AGALACTIAE; VERTICAL TRANSMISSION; VERY LOW BIRTH WEIGHT;

DEVELOPING COUNTRIES; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; INTENSIVE CARE UNITS, NEONATAL; MORBIDITY; RISK FACTORS; SEPSIS; SURVIVAL RATE;

EID: 84873175957     PISSN: 00414301     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath P T. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed 2005; 90: 220-224.
2. Thaver D, Zaidi AK. Burden of neonatal infections in developing countries: a review of evidence from community-based studies. Pediatr Infect Dis J 2009; 28(Suppl): S3-S9.
3. [No authors listed]. Neonatal morbidity and mortality: report of the National Neonatal-Perinatal Database. Indian Pediatr 1997; 34: 1039-1042.
4. Ali Z. Neonatal bacterial septicaemia at the Mount Hope Women's Hospital, Trinidad. Ann Trop Paediatr 2004; 24: 41-44.
5. Chacko B, Sohi I. Early onset neonatal sepsis. Indian J Pediatr 2005; 72: 23-26.
6. Wattal C, Oberoi JK. Neonatal sepsis. Indian J Pediatr 2011; 78: 473-474.
7. Turkish Neonatal Society; Nosocomial Infections Study Group. Nosocomial infections in neonatal units in Turkey: epidemiology, problems, unit policies and opinions of healthcare workers. Turk J Pediatr 2010; 52: 50-57.
8. Stoll BJ, Hansen NI, Higgins RD, et al. National Institute of Child Health and Human Development. Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003. Pediatr Infect Dis J 2005; 24: 635-639.
9. Kermorvant-Duchemin E, Laborie S, Rabilloud M, Lapillonne A, Claris O. Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med 2008; 9: 186-191.
10. Wynn J, Cornell TT, Wong HR, Shanley T P, Wheeler DS. The host response to sepsis and developmental impact. Pediatrics 2010; 125: 1031-1041.
11. Stoll BJ, Hansen NI, Sánchez PJ, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics 2011; 127: 817-826.
12. Hall SL, Hall RT, Barnes WG, et al. Relationship of maternal to neonatal colonization with coagulase- negative staphylococci. Am J Perinatol 1990; 7: 384-388.
13. Hyde TB, Hilger TM, Reingold A, Farley MM, O'Brien KL, Schuchat A. Active Bacterial Core surveillance (ABCs) of the Emerging Infections Program Network Trends in incidence and antimicrobial resistance of early-onset sepsis: population-based surveillance in San Francisco and Atlanta. Pediatrics 2002; 110: 690-695.
14. Zaidi AK, Thaver D, Ali SA, Khan TA. Pathogens associated with sepsis in newborns and young infants in developing countries. Pediatr Infect Dis J 2009; 28(Suppl): S10-S18.
15. Yapicioglu H, Satar M, Ozcan K, et al. A 6-year prospective surveillance of healthcare-associated infections in a neonatal intensive care unit from southern part of Turkey. J Paediatr Child Health 2010; 46: 337-342.
16. Baş AY, Demirel N, Zenciroglu A, Göl N, Tanir G. Nosocomial blood stream infections in a neonatal intensive care unit in Ankara, Turkey. Turk J Pediatr 2010; 52: 464-470.
17. Wynn JL, Levy O. Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol 2010; 37: 307-337.
18. Bauer K, Zemlin M, Hummel M, et al. Diversification of Ig heavy chain genes in human preterm neonates prematurely exposed to environmental antigens. J Immunol 2002; 169: 1349-1356.
19. Maródi L. Innate cellular immune responses in newborns. Clin Immunol 2006; 118: 137-144.
20. Kenzel S, Henneke P. The innate immune system and its relevance to neonatal sepsis. Curr Opin Infect Dis 2006; 19: 264-270.
21. Ganatra HA, Stoll BJ, Zaidi AK. International perspective on early-onset neonatal sepsis. Clin Perinatol 2010; 37: 501-523.
22. Zingarelli B, Hake P W, O'Connor M, et al. Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma. Crit Care Med 2009; 37: 1978-1987.
23. Wynn JL, Scumpia PO, Delano MJ, et al. Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock 2007; 28: 675-683.
24. Salem SY, Sheiner E, Zmora E, Vardi H, Shoham-Vardi I, Mazor M. Risk factors for early neonatal sepsis. Arch Gynecol Obstet 2006; 274: 198-202.
25. Nizet V, Klein JO. Bacterial sepsis and meningitis. In: Remington JS, Klein JO, Wilson CB, Nizet V, Maldonada YA (eds). Infectious Diseases of the Fetus and Newborn Infant (7th ed). Philadelphia: Elsevier; 2011: 222-275.
26. Greenberg D, Shinwell ES, Yagupsk P, et al. A prospective study of neonatal sepsis and meningitis in Southern Israel. Pediatr Infect Dis J 1997; 16: 197.
27. Shin YJ, Ki M, Foxman B. Epidemiology of neonatal sepsis in South Korea. Pediatr Int 2009; 51: 225-232.
28. rd. Second-stage fetal tachycardia and neonatal infection. Am J Obstet Gynecol 1984; 148: 779-781.
29. Fanaroff AA, Korones SB, Wright LL, et al. Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infants. The National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Infect Dis J 1998; 17: 593-598.
30. Metsvaht T, Pisarev H, Ilmoja ML, et al. Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis. BMC Pediatr 2009; 9: 72.
31. Ng PC, Lam HS. Diagnostic markers for neonatal sepsis. Curr Opin Pediatr 2006; 18: 125-131.
32. Turner D, Hammerman C, Rudensky B, Schlesinger Y, Goia C, Schimmel MS. Procalcitonin in preterm infants during the first few days of life: introducing an age related nomogram. Arch Dis Child Fetal Neonatal Ed 2006; 91: 283-286.
33. Ng PC, Li G, Chui KM, et al. Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection. Pediatr Res 2004; 56: 796-803.
34. Layseca-Espinosa E, Pérez-González L F, Torres-Montes A, et al. Expression of CD64 as a potential marker of neonatal sepsis. Pediatr Allergy Immunol 2002; 13: 319-327.
35. Pavcnik - Arnol M, Hojker S, Derganc M. Lipopolysaccharide-binding protein in critically illneonates and children with suspected infection: comparison with procalcitonin, interleukin-6, and Creactive protein. Intensive Care Med 2004; 30: 1454-1460.
36. Behrendt D, Dembinski J, Heep A, Bartmann P. Lipopolysaccharide binding protein in preterm infants. Arch Dis Child Fetal Neonatal Ed 2004; 89: 551-554.
37. Groselj-Grenc M, Ihan A, Pavcnik-Arnol M, Kopitar AN, Gmeiner-Stopar T, Derganc M. Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and Creactive protein in sepsis of critically ill neonates and children. Intensive Care Med 2009; 35: 1950-1958.
38. Schultz C, Temming P, Bucsky P, Göpel W, Strunk T, Härtel C. Immature anti-inflammatory response in neonates. Clin Exp Immunol 2004; 135: 130-136.
39. Hotoura E, Giapros V, Kostoula A, Spirou P, Andronikou S. Tracking changes of lymphocyte subsets and pre- inflammatory mediators in full-term neonates with suspected or documented infection. Scand J Immunol 2011; 73: 250-255.
40. Døllner H, Vatten L, Austgulen R. Early diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6, soluble tumour necrosis factor receptors and soluble adhesion molecules. J Clin Epidemiol 2001; 54: 1251-1257.
41. Chirico G, Loda C. Laboratory aid to the diagnosis and therapy of infection in the neonate. Pediatr Rep 2011; 3: e1.
42. Benitz WE. Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clin Perinatol 2010; 37: 421-438.
43. Santana Reyes C, García-Muñoz F, Reyes D, González G, Dominguez C, Domenech E. Role of cytokines (interleukin-1beta, 6, 8, tumour necrosis factor-alpha, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis. Acta Paediatr 2003; 92: 221-227.
44. Juretić E, Juretić A, Uzarević B, Petrovecki M. Alterations in lymphocyte phenotype of infected preterm newborns. Biol Neonate 2001; 80: 223-227.
45. Godula-Stuglik U, Mazur B, Mikusz G, Torbus T, Tomanek L. Lymphocyte subpopulations in full-term septic neonates. Pediatr Int 1999; 41: 500-505.
46. Hodge G, Hodge S, Han P, Haslam R. Multiple leucocyte activation markers to detect neonatal infection. Clin Exp Immunol 2004; 135: 125-129.
47. Barton P, Garcia J, Kouatli A, et al. Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study. Chest 1996; 109: 1302-1312.
48. Paradisis M, Evans N, Kluckow M, Osborn D. Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants. J Pediatr 2009; 154: 189-195.
49. Seri I, Noori S. Diagnosis and treatment of neonatal hypotension outside the transitional period. Early Hum Dev 2005; 81: 405-411.
50. Meyer S, Gottschling S, Gortner L. Arginine-vasopressin as a rescue therapy in children and neonates for catecholamine resistant shock. Eur J Pediatr 2008; 167: 357.
51. Meyer S, Loffler G, Polcher T, et al. Vasopressin in catecholamine-resistant septic and cardiogenic shock in very-low-birthweight infants. Acta Paediatr 2006; 95: 1309-1312.
52. Ohlsson A, Lacy JB. Intravenous immunoglobulin for preventing infection in preterm and/or low-birth- weight infants. Cochrane Database Syst Rev 2004; (1): CD000361.
53. Haque KN, Pammi M. Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates. Cochrane Database Syst Rev 2011; (10): CD004205.
54. Lauterbach R, Pawlik D, Kowalczyk D, Ksycínski W, Helwich E, Zembala M. Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial. Crit Care Med 1999; 27: 807-814.
55. Mohan P, Brocklehurst P. Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropaenia. Cochrane Database Syst Rev 2003; (4): CD003956.
56. Tarnow-Mordi W, Isaacs D, Dutta S. Adjunctive immunologic interventions in neonatal sepsis. Clin Perinatol 2010; 37: 481-499.
57. Northern Neonatal Nursing Initiative Trial Group. Randomised trial of prophylactic early fresh-frozen plasma or gelatin or glucose in preterm babies: outcome at 2 years. Lancet 1996; 348: 229-232.