메뉴 건너뛰기




Volumn 11, Issue 7, 2012, Pages 933-936

Amyotrophic lateral sclerosis treatment with ultramicronized palmitoylethanolamide: A case report

Author keywords

Electromyography; Mast cells; Microglia; Motor neuron disease; Neurodegeneration; Palmitoylethanolamide; Spinal inflammation

Indexed keywords

NORMAST; PALMIDROL; UNCLASSIFIED DRUG;

EID: 84873158343     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527311201070933     Document Type: Article
Times cited : (23)

References (25)
  • 1
    • 77952963099 scopus 로고    scopus 로고
    • Motor neurone disease: A practical update on diagnosis and management
    • Wood-Allum, C.; Shaw, P.J. Motor neurone disease: a practical update on diagnosis and management. Clin. Med., 2010, 10(3), 252-258.
    • (2010) Clin. Med. , vol.10 , Issue.3 , pp. 252-258
    • Wood-Allum, C.1    Shaw, P.J.2
  • 3
    • 80755163102 scopus 로고    scopus 로고
    • Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
    • Ferraiuolo, L.; Kirby, J.; Grierson, A.J.; Sendtner, M.; Shaw, P.J. Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat. Rev. Neurol., 2011, 7(11), 616-630.
    • (2011) Nat. Rev. Neurol. , vol.7 , Issue.11 , pp. 616-630
    • Ferraiuolo, L.1    Kirby, J.2    Grierson, A.J.3    Sendtner, M.4    Shaw, P.J.5
  • 4
    • 53049105819 scopus 로고    scopus 로고
    • ALS drug development: Reflections of the past and a way forward
    • Aggarwal, S.; Cudkowicz, M. ALS drug development: reflections of the past and a way forward. Neurotherapeutics, 2008, 5(4), 516-527.
    • (2008) Neurotherapeutics , vol.5 , Issue.4 , pp. 516-527
    • Aggarwal, S.1    Cudkowicz, M.2
  • 5
    • 49649095887 scopus 로고    scopus 로고
    • Neuroscience: Standard model
    • Schnabel, J. Neuroscience: standard model. Nature, 2008, 454(7205), 682-685.
    • (2008) Nature , vol.454 , Issue.7205 , pp. 682-685
    • Schnabel, J.1
  • 6
    • 84856905668 scopus 로고    scopus 로고
    • Current and prospective diseasemodifying therapies for amyotrophic lateral sclerosis
    • Morren, J.A.; Galvez-Jimenez, N. Current and prospective diseasemodifying therapies for amyotrophic lateral sclerosis. Expert Opin. Investig. Drugs, 2012, 21(3), 297-320.
    • (2012) Expert Opin. Investig. Drugs , vol.21 , Issue.3 , pp. 297-320
    • Morren, J.A.1    Galvez-Jimenez, N.2
  • 7
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • Di Marzo, V. Targeting the endocannabinoid system: to enhance or reduce? Nat. Rev. Drug Dis., 2008, 7(5), 438-455.
    • (2008) Nat. Rev. Drug Dis. , vol.7 , Issue.5 , pp. 438-455
    • Di Marzo, V.1
  • 8
    • 0036797445 scopus 로고    scopus 로고
    • Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: Inhibition of nitric oxide and cyclo-oxygenase systems
    • Costa, B.; Conti, S.; Giagnoni, G.; Colleoni, M. Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systems. Br. J. Pharmacol., 2002, 137(4), 413-420.
    • (2002) Br. J. Pharmacol. , vol.137 , Issue.4 , pp. 413-420
    • Costa, B.1    Conti, S.2    Giagnoni, G.3    Colleoni, M.4
  • 9
    • 53349089891 scopus 로고    scopus 로고
    • The endogenous fatty acid amide, palmitoylethanolamide, has antiallodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: Involvement of CB1, TRPV1 and PPAR receptors and neurotrophic factors
    • Costa, B.; Comelli, F.; Bettoni, I.; Colleoni, M.; Giagnoni, G. The endogenous fatty acid amide, palmitoylethanolamide, has antiallodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPAR receptors and neurotrophic factors. Pain, 2008, 139(3), 541-550.
    • (2008) Pain , vol.139 , Issue.3 , pp. 541-550
    • Costa, B.1    Comelli, F.2    Bettoni, I.3    Colleoni, M.4    Giagnoni, G.5
  • 12
    • 79960209448 scopus 로고    scopus 로고
    • Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury
    • Esposito, E.; Paterniti, I.; Mazzon, E.; Genovese, T.; Di Paola, R.; Galuppo, M.; Cuzzocrea, S. Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury. Brain Behav. Immun., 2011, 25(6), 1099-1112.
    • (2011) Brain Behav. Immun. , vol.25 , Issue.6 , pp. 1099-1112
    • Esposito, E.1    Paterniti, I.2    Mazzon, E.3    Genovese, T.4    Di Paola, R.5    Galuppo, M.6    Cuzzocrea, S.7
  • 13
    • 0029870716 scopus 로고    scopus 로고
    • The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons
    • Skaper, S.D.; Buriani, A.; Dal Toso, R.; Petrelli, L.; Romanello, S.; Facci, L.; Leon, A. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc. Natl. Acad Sci USA, 1996, 93(9), 3984-3989.
    • (1996) Proc. Natl. Acad Sci USA , vol.93 , Issue.9 , pp. 3984-3989
    • Skaper, S.D.1    Buriani, A.2    Dal Toso, R.3    Petrelli, L.4    Romanello, S.5    Facci, L.6    Leon, A.7
  • 15
    • 84866299618 scopus 로고    scopus 로고
    • Palmitoylethanolamide in the treatment of chronic pain caused by different etiopathogeneses
    • In press
    • Gatti, A.; Lazzari, M.; Gianfelice, V.; Di Paolo, A.; Sabato, E.; Sabato, A.F. Palmitoylethanolamide in the treatment of chronic pain caused by different etiopathogeneses. Pain Med. 2012, In press.
    • (2012) Pain Med.
    • Gatti, A.1    Lazzari, M.2    Gianfelice, V.3    Di Paolo, A.4    Sabato, E.5    Sabato, A.F.6
  • 16
    • 79954608945 scopus 로고    scopus 로고
    • Emerging targets and treatments in amyotrophic lateral sclerosis
    • Zinman, L.; Cudkowicz, M. Emerging targets and treatments in amyotrophic lateral sclerosis. Lancet Neurol., 2011, 10(5), 481-490.
    • (2011) Lancet Neurol. , vol.10 , Issue.5 , pp. 481-490
    • Zinman, L.1    Cudkowicz, M.2
  • 17
    • 60849093466 scopus 로고    scopus 로고
    • Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
    • Rothstein, J.D. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann. Neurol., 2009, 65(Suppl. 1), S3-S9.
    • (2009) Ann. Neurol. , vol.65 , Issue.SUPPL. 1
    • Rothstein, J.D.1
  • 21
    • 3042559925 scopus 로고    scopus 로고
    • Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice
    • Witting, A.; Weydt, P.; Hong, S.; Kliot, M.; Moller, T.; Stella, N. Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice. J. Neurochem., 2004, 89(6), 1555-1557.
    • (2004) J. Neurochem. , vol.89 , Issue.6 , pp. 1555-1557
    • Witting, A.1    Weydt, P.2    Hong, S.3    Kliot, M.4    Moller, T.5    Stella, N.6
  • 22
    • 33845683331 scopus 로고    scopus 로고
    • Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice
    • Bilsland, L.G.; Dick, J.R.; Pryce, G.; Petrosino, S.; Di Marzo, V.; Baker, D.; Greensmith, L. Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice. FASEB J., 2006, 20(7), 1003-1005.
    • (2006) FASEB J. , vol.20 , Issue.7 , pp. 1003-1005
    • Bilsland, L.G.1    Dick, J.R.2    Pryce, G.3    Petrosino, S.4    Di Marzo, V.5    Baker, D.6    Greensmith, L.7
  • 23
    • 0028906566 scopus 로고
    • Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide
    • Facci, L.; Dal Toso, R.; Romanello, S.; Buriani, A.; Skaper, S.D.; Leon, A. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc. Natl. Acad. Sci. USA, 1995, 92(8), 3376-3380.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , Issue.8 , pp. 3376-3380
    • Facci, L.1    Dal Toso, R.2    Romanello, S.3    Buriani, A.4    Skaper, S.D.5    Leon, A.6
  • 24
    • 0042320663 scopus 로고    scopus 로고
    • Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility
    • Franklin, A.; Parmentier-Batteur, S.; Walter, L.; Greenberg, D.A.; Stella, N. Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. J. Neurosci., 2003, 23(21), 7767-7775.
    • (2003) J. Neurosci. , vol.23 , Issue.21 , pp. 7767-7775
    • Franklin, A.1    Parmentier-Batteur, S.2    Walter, L.3    Greenberg, D.A.4    Stella, N.5
  • 25
    • 0036330324 scopus 로고    scopus 로고
    • Release of fatty acid amides in a patient with hemispheric stroke: A microdialysis study
    • Schäbitz, W.R.; Giuffrida, A.; Berger, C.; Aschoff, A.; Schwaninger, M.; Schwab, S.; Piomelli, D. Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. Stroke, 2002, 33(8), 2112-2114.
    • (2002) Stroke , vol.33 , Issue.8 , pp. 2112-2114
    • Schäbitz, W.R.1    Giuffrida, A.2    Berger, C.3    Aschoff, A.4    Schwaninger, M.5    Schwab, S.6    Piomelli, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.