Hsp72 mediates stronger antigen-dependent non-classical MHC class Ib anti-tumor responses than hsc73 in Xenopus laevis

Cancer Immunity

Volumn 13, Issue 1, 2013, Pages

  Nedelkovska, Hristina ^a   Robert, Jacques ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Comparative immunology; Heat shock proteins; Tumor immunity; Xenopus laevis

Indexed keywords

HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 72; HLA ANTIGEN CLASS 1; HLA B ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS PRESENTATION; DRUG POTENCY; GENE DELIVERY SYSTEM; IMMUNOGENICITY; IMMUNOSTIMULATION; IN VIVO STUDY; MINOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PROTEIN STABILITY; SKIN GRAFT; SOLID TUMOR; TUMOR IMMUNITY; XENOPUS LAEVIS;

EID: 84873154583     PISSN: 14249634     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Kiang JG, Tsokos GC. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 1998; 80: 183-201. (PMID: 9839771)
2. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002; 2: 185-194. (PMID: 11913069)
3. Calderwood SK, Theriault JR, Gong J. Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity. Eur J Immunol 2005; 35: 2518-2527. (PMID: 16144035)
4. Robert J. Evolution of heat shock protein and immunity. Dev Comp Immunol 2003; 27: 449-464. (PMID: 12697304)
5. Castellino F, Boucher PE, Eichelberg K, Mayhew M, Rothman JE, Houghton AN, Germain RN. Receptor-mediated uptake of antigen/ heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J Exp Med 2000; 191: 1957-1964.
6. Bendz H, Ruhland SC, Pandya MJ, Hainzl O, Riegelsberger S, Brauchle C, Mayer MP, Buchner J, Issels RD, Noessner E. Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling. J Biol Chem 2007; 282: 31688-31702. (PMID: 17684010)
7. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Fin-berg RW, Koo GC, Calderwood SK. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000; 6: 435-442. (PMID: 10742151)
8. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002; 277: 15028-15034. (PMID: 11836257)
9. Basu S, Binder RJ, Suto R, Anderson KM, Srivastava PK. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol 2000; 12: 1539-1546. (PMID: 11058573)
10. Srivastava PK. Therapeutic cancer vaccines. Curr Opin Immunol 2006; 18: 201-205. (PMID: 16464565)
11. Blachere NE, Li Z, Chandawarkar RY, Suto R, Jaikaria NS, Basu S, Udono H, Srivastava PK. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med 997; 186: 1315-1322. (PMID: 9334371)
12. Nicchitta CV. Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity. Nat Rev Immunol 2003; 3: 427-432. (PMID: 12766764)
13. Robert J, Ménoret A, Basu S, Cohen N, Srivastava PR. Phylogenetic conservation of the molecular and immunological properties of the chaperones gp96 and hsp70. Eur J Immunol 2001; 31: 186-195. (PMID: 11265634)
14. Robert J, Gantress J, Rau L, Bell A, Cohen N. Minor histocompati-bility antigen-specific MHC-restricted CD8 T cell responses elicited by heat shock proteins. J Immunol 2002; 168: 1697-1703. (PMID: 11823499)
15. Mosser DD, Morimoto RI. Molecular chaperones and the stress of oncogenesis. Oncogene 2004; 23: 2907-2918. (PMID: 15077153)
16. Ciocca DR, Calderwood SK. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 2005; 10: 86-103. (PMID: 16038406)
17. Ménoret A, Patry Y, Burg C, Le Pendu J. Co-segregation of tumor immunogenicity with expression of inducible but not constitutive hsp70 in rat colon carcinomas. J Immunol 1995; 155: 740-747 (PMID: 7608552)
18. Callahan MK, Chaillot D, Jacquin C, Clark PR, Ménoret A. Differential acquisition of antigenic peptides by Hsp70 and Hsc70 under oxidative conditions. J Biol Chem 2002; 277: 33604-33609. (PMID 12114509)
19. Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveil-lance: immunoselection and immunosubversion. Nat Rev Immuno 2006; 6: 715-727. (PMID: 16977338)
20. Gomes AQ, Correia DV, Silva-Santos B. Non-classical major histo-compatibility complex proteins as determinants of tumour immu-nosurveillance. EMBO Rep 2007; 8: 1024-1030. (PMID: 17972902)
21. de Kruijf EM, Sajet A, van Nes JG, Natanov R, Putter H, Smit VT Liefers GJ, van der Elsen PJ, van der Velde CJ, Kuppen PJ. HLA-E and HLA-G expression in classical HLA class I-negative tumors is o prognostic value for clinical outcome of early breast cancer patients J Immunol 2010; 185: 7452-7459. (PMID: 21057081)
22. Belicher PA, Rollins-Smith LA, Jacobs DM, Cohen N. Mitogenic responses of frog lymphocytes to crude and purified preparations o bacterial lipopolysaccharide (LPS). Dev Comp Immunol 1983; 7 483-496. (PMID: 6357879)
23. Robert J, Gantress J, Cohen N, Maniero GD. Xenopus as an experimental model for studying evolution of hsp-immune system interactions. Methods 2004; 32: 42-53. (PMID: 14624877)
24. Robert J, Guiet C, Du Pasquier L. Lymphoid tumors of Xenopus lae-vis with different capacities for growth in larvae and adults. Dev Immunol 1994; 3: 297-307. (PMID: 7620321)
25. Arnall JC, Horton JD. Impaired rejection of minor-histocompatibil-ity-antigen-disparate skin grafts and acquisition of tolerance to thy-mus donor antigens in allothymus-implanted, thymectomized Xenopus. Transplantation 1986; 41: 766-776. (PMID: 2940739)
26. Flajnik MF, Du Pasquier L, Cohen N. Immune responses of thy-mus/lymphocyte embryonic chimeras: studies on tolerance and major histocompatibility complex restriction in Xenopus. Eur J Immunol 1985; 15: 540-547. (PMID: 3874068)
27. Rau L, Cohen N, Robert J. MHC-restricted and -unrestricted CD8 T cells: an evolutionary perspective. Transplantation 2001; 72: 1830-1835. (PMID: 11740396)
28. Robert J, Ramanayake T, Maniero GD, Morales H, Chida AS. Phy-logenetic conservation of glycoprotein 96 ability to interact with CD91 and facilitate antigen cross-presentation. J Immunol 2008 180: 3176-3182. (PMID: 18292541)
29. Goyos A, Ohta Y, Guselnikov S, Robert J. Novel nonclassical MHC class Ib genes associated with CD8 T cell development and thymic tumors. Mol Immunol 2009; 46: 1775-1786. (PMID: 19237199)
30. Goyos A, Cohen N, Gantress J, Robert J. Anti-tumor MHC class Ia unrestricted CD8 T cell cytotoxicity elicited by the heat shock pro tein gp96. Eur J Immunol 2004; 34: 2449-2458. (PMID: 15307177)
31. Gong J, Zhang Y, Durfee J, Weng D, Liu C, Koido S, Song B, Apos-tolopoulos V, Calderwood SK. A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use. J Immunol 2010; 184: 488-496. (PMID: 19949080)
32. Kobel HR, Du Pasquier L. Strains and species of Xenopus for immu-nological research. Amsterdam: Elsevier/North Holland Publishing Co.; 1977.
33. Kobel HR, Du Pasquier L. Production of large clones of histocom-patible, fully identical clawed toads (Xenopus). Immunogenetics 1975; 2: 87-91.
34. Xenopus laevis Research Resource for Immunobiology. Accessed from: http://www.urmc.rochester.edu/mbi/resources/Xenopus/ index.cfm
35. Johnson AD, Krieg PA. pXeX, a vector for efficient expression of cloned sequences in Xenopus embryos. Gene 1994; 147: 223-226. (PMID: 7926804)
36. Nedelkovska H, Cruz-Luna T, McPherson P, Robert J. Comparative in vivo study of gp96 adjuvanticity in the frog Xenopus laevis. J Vis Exp 2010; 43: 2026. (PMID: 20972386)