Autophagy and apoptosis in tubular cells following unilateral ureteral obstruction are associated with mitochondrial oxidative stress

International Journal of Molecular Medicine

Volumn 31, Issue 3, 2013, Pages 628-636

  Xu, Yanfang ^a   Ruan, Shiwei ^b   Wu, Xiaonan ^a   Chen, Hong ^a   Zheng, Ke ^a   Fu, Binbin ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Autophagy; Mitochondria; Obstructive nephropathy

Indexed keywords

BECLIN 1; HYDROGEN PEROXIDE; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATROPHY; AUTOPHAGY; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FIBROSING ALVEOLITIS; KIDNEY CORTEX; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; KIDNEY TUBULE DISORDER; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; URETER OBSTRUCTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; ENZYME ACTIVATION; HYDROGEN PEROXIDE; KIDNEY; KIDNEY TUBULES, PROXIMAL; MALE; MITOCHONDRIA; NADPH OXIDASE; NEPHRONS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; URETERAL OBSTRUCTION;

EID: 84873125170     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1232     Document Type: Article

References (28)

1. Yang JW and Liu YH: Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 13: 96-107, 2002.
2. Zeisberg M and Neilson EG: Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 21: 1819-1834, 2010.
3. Forbes MS, Thornhill BA and Chevalier RL: Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model. Am J Physiol Renal Physiol 301: F110-F117, 2011.
4. Nishida K, Yamaguchi O and Otsu K: Crosstalk between autophagy and apoptosis in heart disease. Circ Res 103: 343-351, 2008.
5. Luo S and Rubinsztein DC: Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ 17: 268-277, 2010.
6. Kim WY, Nam SA, Song HC, et al: The role of autophagy in unilateral ureteral obstruction rat model. Nephrology 17: 148-159, 2012.
7. Li L, Zepeda-Orozco D, Black R and Lin FM: Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol 176: 1767-1778, 2010.
8. Koesters R, Kaissling B, Lehir M, et al: Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol 177: 632-643, 2010.
9. Ferraro E and Cecconi F: Autophagic and apoptotic response to stress signals in mammalian cells. Arch Biochem Biophys 462: 210-219, 2007.
10. García IM, Altamirano L, Mazzei L, et al: Role of mitochondria in paricalcitol-mediated cytoprotection during obstructive nephropathy. Am J Physiol Renal Physiol 302: F1595-F1605, 2012.
11. Forbes MS, Thornhill BA, Minor JJ, Gordon KA, Galarreta CI, and Chevalier RL: Fight-or-flight: murine unilateral ureteral obstruction causes extensive proximal tubular degeneration, collecting duct dilatation, and minimal fibrosis. Am J Physiol Renal Physiol 303: F120-F129, 2012.
12. Xu YF, Ruan SW, Xie H and Lin JM: Role of LOX-1 in Ang II-induced oxidative functional damage in renal tubular epithelial cells. Int J Mol Med 26: 679-690, 2010.
13. Zhang H, Kong X, Kang J, Su J, Li Y, Zhong JT and Sun LK: Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci 110: 376-388, 2009.
14. Miyajima A, Chen J, Lawrence C, et al: Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney Int 58: 2301-2313, 2000.
15. Docherty NG, O'Sullivan OE, Healy DA, Fitzpatrick JM and Watson RWG: Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction. Am J Physiol Renal Physiol 290: F4-F13, 2006.
16. Ago T, Kuroda J, Pain J, Fu C, Li H and Sadoshima J: Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res 106: 1253-1264, 2010.
17. Chevalier RL and Forbes MS: Generation and evolution of atubular glomeruli in the progression of renal disorders. J Am Soc Nephrol 19: 197-206, 2008.
18. Chevalier RL: Pathogenesis of renal injury in obstructive uropathy. Curr Opin Pediatr 18: 153-160, 2006.
19. Xu YF, Yang SY, Huang JY, Ruan SW, Zheng Z and Lin JM: TGF-β1 induced autophagy and promoted apoptosis in renal tubular epithelial cells. Int J Mol Med 29: 781-790, 2012.
20. Kuroda J, Ago T, Matsushima SJ, Zhai PY, Schneiderb MD and Sadoshim J: NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci USA 107: 15565-15570, 2010.
21. Martinet W and De Meyer GR: Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential. Circ Res 104: 304-317, 2009.
22. Addabbo F, Montagnani M and Goligorsky MS: Mitochondria and reactive oxygen species. Hypertension 53: 885-892, 2009.
23. Periyasamy-Thandavan S, Jiang M, Wei Q, Smith R, Yin XM and Dong Z: Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney Int 74: 631-640, 2008.
24. Rhyu DY, Yang YQ, Ha H, Lee GT, Song JS, Uh ST and Lee HB: Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 16: 667-675, 2005.
25. Rasbach KA and Schnellmann RG: Signaling of mitochondrial biogenesis following oxidant injury. J Biol Chem 25: 2355-2362, 2007.
26. Robert G, Gastaldi C, Puissant A, et al: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy 8: 1-13, 2012.
27. Oberstein A, Jeffrey PD and Shi Y: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 282: 13123-13132, 2007.
28. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122: 927-939, 2005.