Simultaneous quantification of seven plasma metabolites of sulfur mustard by ultra high performance liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 917-918, Issue , 2013, Pages 100-107

  Li, Chunzheng ^a   Chen, Jia ^a   Liu, Qin ^a   Xie, Jianwei ^a   Li, Hua ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Biomarker; Metabolite; Plasma; Quantification; Sulfur mustard; Toxicokinetics; UPLC MS MS

Indexed keywords

BIOLOGICAL SAMPLES; EARLY DIAGNOSIS; HAZARDOUS CHEMICALS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMITS; MATRIX EFFECTS; MILITARY CONFLICTS; PLASMA METABOLITES; PLASMA PROFILES; PROTEIN PRECIPITATION; QUANTIFICATION; QUANTITATIVE METHOD; RAT PLASMA; RELATIVE STANDARD DEVIATIONS; SAMPLE PREPARATION; SIMULTANEOUS DETERMINATIONS; SULFUR MUSTARD; THIODIGLYCOL; TIME WINDOWS; TOXICOKINETICS; ULTRA HIGH PERFORMANCE; UPLC-MS/MS;

ACETONITRILE; BIOMARKERS; BODY FLUIDS; CHEMICAL WARFARE; CHROMATOGRAPHY; COMMERCE; ETHANE; GLYCOLS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; METHANOL; PLASMAS; SULFUR;

BIOMOLECULES;

1 METHYLSULFINYL 2 [2 (METHYLTHIO)ETHYLSULFONYL]ETHANE; 1,1' SULFONYLBIS[2 (METHYLSULFINYL)ETHANE]; 1,1' SULFONYLBIS[2 S(N ACETYLCYSTEINYL)ETHANE; ACETONITRILE; BIS BETA CHLOROETHYL SULFOXIDE; DRUG METABOLITE; METHANOL; MUSTARD GAS; THIODIGLYCOL; THIODIGLYCOL SULFOXIDE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; HALF LIFE TIME; HYDROLYSIS; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; METABOLITE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICOKINETICS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY;

ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LINEAR MODELS; MALE; MUSTARD GAS; PHARMACOKINETICS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84873122499     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.12.035     Document Type: Article

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