Development and validation of efficient stable isotope dilution LC-HESI-MS/MS method for the verification of β-lyase metabolites in human urine after sulfur mustard exposure

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 13-14, 2011, Pages 908-914

  Halme, Mia ^a   Karjalainen, Maaret ^a   Kiljunen, Harri ^a   Vanninen, Paula ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Lyase metabolites; Biomarker; LC HESI MS MS; SPE; Sulfur mustard; Validation

Indexed keywords

CHEMICAL WEAPONS; CONCENTRATION RANGES; CONFIDENCE BUILDING; CORRELATION COEFFICIENT; CYCLE TIME; ELUENTS; HEATED ELECTROSPRAY IONIZATION; HUMAN URINE; INTERNAL STANDARDS; LC-HESI-MS/MS; LC-MS/MS; LIMITS OF DETECTION; LOWER LIMITS; METHOD VALIDATIONS; POST-COLUMN; QUANTITATIVE METHOD; RETENTION TIME; SAMPLE MATRIX; SAMPLE PREPARATION PROCEDURE; SOLID PHASE EXTRACTION CARTRIDGES; SPE; STABLE ISOTOPE DILUTION; SULFUR MUSTARD; VALIDATED METHODS; VALIDATION;

BIOMARKERS; BIOMOLECULES; BODY FLUIDS; COLUMN CHROMATOGRAPHY; DEUTERIUM; ELECTROSPRAY IONIZATION; ETHANE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; SULFUR; SULFUR DETERMINATION;

EXTRACTION;

1 METHYLSULFINYL 2 [2 (METHYLTHIO)ETHYLSULFONYL]ETHANE; 1,1' SULFONYLBIS [2 (METHYLSULFINYL)ETHANE]; BETA LYASE; ETHANE; ISOTOPE; LYASE; MUSTARD GAS; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; ELECTROSPRAY; FOOD AND DRUG ADMINISTRATION; HUMAN; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE; VALIDATION PROCESS;

ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CHEMICAL WARFARE AGENTS; HUMANS; ISOTOPE LABELING; LINEAR MODELS; LYASES; MUSTARD GAS; POISONING; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFIDES; SULFONES; SULFOXIDES; TANDEM MASS SPECTROMETRY;

EID: 79953311843     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.02.043     Document Type: Article

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