Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 5, 2013, Pages

  Baldridge, Ryan D ^a   Graham, Todd R ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

ATP8A1; ATP8A2; Flippase; P4 ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DNF1 PROTEIN; DRS2 PROTEIN; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CLUSTER ANALYSIS; CONTROLLED STUDY; ENZYME SPECIFICITY; GENETIC SCREENING; MEMBRANE LEAFLET; NONHUMAN; PHOSPHOLIPID MEMBRANE; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; YEAST;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; AMINO ACIDS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CALCIUM-TRANSPORTING ATPASES; CELL MEMBRANE; GREEN FLUORESCENT PROTEINS; LIPID BILAYERS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLSERINES; PHOSPHOLIPID ETHERS; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84873113579     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1216948110     Document Type: Article

References (28)

1. Sebastian TT, Baldridge RD, Xu P, Graham TR (2012) Phospholipid flippases: Building asymmetric membranes and transport vesicles. Biochim Biophys Acta 1821(8):1068-1077.
2. Juliano RL, Ling V (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455(1):152-162.
3. Dean M, Annilo T (2005) Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Annu Rev Genomics Hum Genet 6:123-142. (Pubitemid 41397078)
4. Locher KP, Lee AT, Rees DC (2002) The E. coli BtuCD structure: A framework for ABC transporter architecture and mechanism. Science 296(5570):1091-1098. (Pubitemid 34517120)
5. Ward A, Reyes CL, Yu J, Roth CB, Chang G (2007) Flexibility in the ABC transporter MsbA: Alternating access with a twist. Proc Natl Acad Sci USA 104(48):19005-19010.
6. Gourdon P, et al. (2011) Crystal structure of a copper-transporting PIB-type ATPase. Nature 475(7354):59-64.
7. Morth JP, et al. (2007) Crystal structure of the sodium-potassium pump. Nature 450(7172):1043-1049. (Pubitemid 350273618)
8. Pedersen BP, Buch-Pedersen MJ, Morth JP, Palmgren MG, Nissen P (2007) Crystal structure of the plasma membrane proton pump. Nature 450(7172):1111-1114. (Pubitemid 350273616)
9. Toyoshima C, Nakasako M, Nomura H, Ogawa H (2000) Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution. Nature 405(6787):647-655. (Pubitemid 30428644)
10. Post RL, Hegyvary C, Kume S (1972) Activation by adenosine triphosphate in the phosphorylation kinetics of sodium and potassium ion transport adenosine triphosphatase. J Biol Chem 247(20):6530-6540.
11. Toyoshima C, Nomura H, Tsuda T (2004) Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues. Nature 432(7015):361-368. (Pubitemid 39555518)
12. +-ATPase ion pumps. Nat Rev Mol Cell Biol 12(1):60-70.
13. Baldridge RD, Graham TR (2012) Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases. Proc Natl Acad Sci USA 109(6):E290-E298.
14. +-pump. Biochim Biophys Acta 1791(7):603-611.
15. Coleman JA, Vestergaard AL, Molday RS, Vilsen B, Peter Andersen J (2012) Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2. Proc Natl Acad Sci USA 109(5):1449-1454.
16. Thøgersen L, Nissen P (2012) Flexible P-type ATPases interacting with the membrane. Curr Opin Struct Biol 22(4):491-499.
17. Ding J, et al. (2000) Identification and functional expression of four isoforms of ATPase II, the putative aminophospholipid translocase. Effect of isoform variation on the ATPase activity and phospholipid specificity. J Biol Chem 275(30):23378-23386. (Pubitemid 30646241)
18. Natarajan P, Wang J, Hua Z, Graham TR (2004) Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function. Proc Natl Acad Sci USA 101(29):10614-10619. (Pubitemid 38955790)
19. Zhou X, Graham TR (2009) Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast. Proc Natl Acad Sci USA 106(39):16586-16591.
20. Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-1254. (Pubitemid 36337466)
21. Riekhof WR, et al. (2007) Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: The role of P-type ATPases in transport and a broad specificity acyltransferase in acylation. J Biol Chem 282(51):36853-36861.
22. Hanson PK, Malone L, Birchmore JL, Nichols JW (2003) Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. J Biol Chem 278(38):36041-36050. (Pubitemid 37139924)
23. Kean LS, Fuller RS, Nichols JW (1993) Retrograde lipid traffic in yeast: Identification of two distinct pathways for internalization of fluorescent-labeled phosphatidylcholine from the plasma membrane. J Cell Biol 123(6 Pt 1):1403-1419. (Pubitemid 24012020)
24. Navarro J, et al. (1985) Interaction of duramycin with artificial and natural membranes. Biochemistry 24(17):4645-4650. (Pubitemid 15233716)
25. Parsons AB, et al. (2006) Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell 126(3):611-625. (Pubitemid 44163601)
26. Obara K, et al. (2005) Structural role of countertransport revealed in Ca (2+) pump crystal structure in the absence of Ca (2+). Proc Natl Acad Sci USA 102(41):14489-14496. (Pubitemid 41457085)
27. Paterson JK, et al. (2006) Lipid specific activation of the murine P4-ATPase Atp8a1(ATPase II). Biochemistry 45 (16):5367-5376.
28. Gietz RD, Woods RA (2006) Yeast transformation by the LiAc/SS Carrier DNA/PEG method. Methods Mol Biol 313:107-120.