Cytotoxic limonoids from melia azedarach

Planta Medica

Volumn 79, Issue 2, 2013, Pages 163-168

  Yuan, Chun Mao ^a,b   Zhang, Yu ^b   Tang, Gui Hua ^b   Li, Yan ^b   He, Hong Ping ^b   Li, Shi Fei ^b   Hou, Li ^b   Li, Xing Yao ^b   Di, Ying Tong ^b   Li, Shun Lin ^b   Hua, Hui Ming ^a   Hao, Xiao Jiang ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

chemical constituents; cytotoxicities; limonoids; Melia azedarach Linn; Meliaceae

Indexed keywords

17BETA,20BETA EPOXYERGOSTA 5,24(28)DIENE 3BETA,16BETA,22ALPHA TRIOL; 1ALPHA,4ALPHA,6BETA TRIHYDROXYEUDESMANE; CYTOTOXIC AGENT; LIMONOID; MELIA AZEDARACH EXTRACT; MESENDANIN K; MESENDANIN M; SESQUITERPENOID; STEROID; TRITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; MASS SPECTROMETRY; MELIA AZEDARACH; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LIMONINS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MELIA AZEDARACH; MOLECULAR STRUCTURE; PLANT BARK; PLANT EXTRACTS; SESQUITERPENES; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

MELIA AZEDARACH; MELIACEAE;

EID: 84873056491     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328069     Document Type: Article

References (25)

1. Fang X., Di Y. T., Hao X. J. The advances in the limonoid chemistry of the Meliaceae family. Curr Org Chem: 2011; 15 1363 1391
2. Tan Q. G., Luo X. D. Meliaceous limonoids: chemistry and biological activities. Chem Rev: 2011; 111 7437 7522
3. Peng H., Mabberley D. J. Meliaceae. Flora of China: 2008; 11 130 131
4. Zhao L., Huo C. H., Shen L. R., Yang Y., Zhang Q., Shi Q. W. Chemical constituents of plants from the genus Melia. Chem Biodivers: 2010; 7 839 859
5. Govindachari T. R., Malathi R., Gopalakrishnan G., Suresh G., Rajan S. S. Isolation of a new tetranortriterpenoid from the uncrushed green leaves of Azadirachta indica. Phytochemistry: 1999; 52 1117 1119 (Pubitemid 30016475)
6. Nakatani M., Simokoro M., Zhou J. B., Okamura H., Iwagawa T., Tadera K., Nakayama N., Naoki H. Limonoids from Melia toosendan. Phytochemistry: 1999; 52 709 714 (Pubitemid 29518686)
7. Siddiqui B. S., Ghiasuddin F. S. Tetracyclic triterpenoids of the fruit coats of Azadirachta indica. Phytochemistry: 1998; 47 1631 1636 (Pubitemid 28242189)
8. Suhag P. Bharati Mahla M., Singh R., Kalidhar S. B. Phytochemical investigation of Melia azedarach roots. J Indian Chem Soc: 2002; 79 548 549 (Pubitemid 37064401)
9. Di Y. T., He H. P., Liu H. Y., Yi P., Zhang Z., Ren Y. L., Wang J. S., Sun Q. Y., Yang F. M., Fang X., Li S. L., Zhu H. J., Hao X. J. Trijugin-type limonoids from the leaves of Cipadessa cinerascens. J Nat Prod: 2007; 70 1352 1355 (Pubitemid 47401580)
10. Fang X., Di Y. T., He H. P., Liu H. Y., Zhang Z., Ren Y. L., Gao Z. L., Gao S., Hao X. J. Cipadonoid A, a novel limonoid with an unprecedented skeleton, from Cipadessa cinerasecns. Org Lett: 2008; 10 1905 1908
11. Cai J. Y., Zhang Y., Luo S. H., Chen D. Z., Tang G. H., Yuan C. M., Di Y. T., Li S. H., Hao X. J., He H. P. Aphanamixoid A, a potent defensive limonoid, with a new carbon skeleton from Aphanamixis polystachya. Org Lett: 2012; 14 2524 2529
12. Zhu F., Di Y. T., Li X. Y., Liu L. L., Zhang Q., Li Y., Hao X. J., He H. P. Neoclerodane diterpenoids from Scutellaria barbata. Planta Med: 2011; 77 1536 1541
13. Takeya K., Qiao Z. S., Hirobe C., Itokawa H. Cytotoxic trichilin-type limonoids from Melia azedarach. Bioorg Med Chem: 1996; 4 1355 1359 (Pubitemid 26284245)
14. Dong S. H., Zhang C. R., He X. F., Liu H. B., Wu Y., Yue J. M. Mesendanins A-J, limonoids from the leaves and twigs of Melia toosendan. J Nat Prod: 2010; 73 1344 1349
15. Xu G. H., Kim J. A., Kim S. Y., Ryu J. C., Kim Y. S., Jung S. H., Kim M. K., Lee S. H. Terpenoids and coumarins isolated from the fruits of Poncirus trifoliata. Chem Pharm Bull: 2008; 56 839 842
16. Xie B. J., Yang S. P., Chen H. D., Yue J. M. Agladupols A-E, triterpenoids from Aglaia duperreana. J Nat Prod: 2007; 70 1532 1535
17. Liu H. B., Zhang C. R., Dong S. H., Dong L., Wu Y., Yue J. M. Limonoids and triterpenoids from the seeds of Melia azedarach. Chem Pharm Bull: 2011; 59 1003 1007
18. Tan Q. G., Li X. N., Chen H., Feng T., Cai X. H., Luo X. D. Sterols and terpenoids from Melia azedarach. J Nat Prod: 2010; 73 693 697
19. Anjaneyulu A. SR, Murthy M., Gowri P. M. Novel epoxy steroids from the Indian ocean soft coral Sarcophyton crassocaule. J Nat Prod: 2000; 63 112 118 (Pubitemid 30078781)
20. Garcia-Granados A., Martínez A., Onorato M. E., Rivas F., Arias J. M. Chemical-microbiological synthesis of 6 β -eudesmanolides by Curvularia lunata cultures from eudesmanes with functions at C-1 and C-6. Tetrahedron: 1991; 47 91 102
21. Itokawa H., Qiao Z. S., Hirobe C., Takeya K. Cytotoxic limonoids and tetranortriterpenoids form Melia azedarach. Chem Pharm Bull: 1995; 43 1171 1175
22. Zhang Y., Tang C. P., Ke C. Q., Li X. Q., Xie H., Ye Y. Limonoids from the fruits of Melia toosendan. Phytochemistry: 2012; 73 106 113
23. Gunning P. J., Jeffs L. B., Isman M. B., Towers G. HN. Two limonoids from Chisocheton microcarpus. Phytochemistry: 1994; 36 1245 1248 (Pubitemid 2118487)
24. Nakatani M., Huang R. C., Okamura H., Iwagawa T., Tadera K. Degraded limonoids from Melia azedarach. Phytochemistry: 1998; 49 1773 1776 (Pubitemid 28559576)
25. Zhang Q., Li Q. S., Liang J. Y., Min Z. D. Limonoids from fruits of Melia toosendan. Acta Pharm Sin: 2010; 45 475 478