The Role of Initial Success Rates and Other Factors in Determining Reliability of Outcomes of Phosphodiesterase Inhibitor Therapy for Erectile Dysfunction: A Pooled Analysis of 17 Placebo-Controlled Trials of Tadalafil for Use as Needed

Journal of Sexual Medicine

Volumn 10, Issue 2, 2013, Pages 541-550

  Sontag, Angelina ^a   Rosen, Raymond C ^b   Litman, Heather J ^b   Ni, Xiao ^a   Araujo, Andre B ^b  

^a ELI LILLY AND COMPANY   (United States)

^b NEW ENGLAND RESEARCH INSTITUTES   (United States)

Author keywords

Erectile dysfunction; PDE5; Phosphodiesterase type 5 inhibitors; Pooled analysis; Reliability of efficacy; Tadalafil

Indexed keywords

ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; TADALAFIL;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; COHORT ANALYSIS; DISEASE SEVERITY; ERECTILE DYSFUNCTION; HUMAN; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; POST HOC ANALYSIS; PRIORITY JOURNAL; PROBABILITY; PROSTATECTOMY; RELIABILITY;

EID: 84873056330     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02901.x     Document Type: Article

References (16)

1. Aytac IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999;84:50-6.
2. American Urological Association Clinical Guidelines. Management of erectile dysfunction: an update. 2005. Available at: http://www.auanet.org/content/clinical-practice-guidelines/clinical-guidelines.cfm?sub=ed (accessed March 7, 2012).
3. Al-Shaiji TF, Brock GB. Phosphodiesterase type 5 inhibitors for the management of erectile dysfunction: Preference and adherence to treatment. Curr Pharm Des 2009;15:3486-95.
4. Axilrod AC. Phosphodiesterase type 5 inhibitor therapy: Identifying and exploring what attributes matter more to clinicians and patients in the management of erectile dysfunction. Curr Med Res Opin 2007;23:3189-98.
5. Goldstein I, Kim E, Steers WD, Pryor JL, Wilde DW, Natanegara F, Wong DG, Ahuja S. Efficacy and safety of tadalafil in men with erectile dysfunction with a high prevalence of comorbid conditions: Results from MOMENTUS: Multiple observations in men with erectile dysfunction in National Tadalafil Study in the US. J Sex Med 2007;4:166-75.
6. Cheng E. Real-life safety and efficacy of vardenafil in the treatment of erectile dysfunction-results from 30, 010 U.S. patients. J Sex Med 2007;4:432-9.
7. Evliyaoǧlu Y, Yelsel K, Kobaner M, Alma E, Saygili M. Efficacy and tolerability of tadalafil for treatment of erectile dysfunction in men taking serotonin reuptake inhibitors. Urology 2011;77:1137-41.
8. Lewis RW, Sadovsky R, Eardley I, O'Leary M, Seftel A, Wang WC, Shen W, Walker DJ, Wong DG, Ahuja S. The efficacy of tadalafil in clinical populations. J Sex Med 2005;2:517-31.
9. Fink HA, Mac Donald R, Rutks I, Nelson DB, Wilt TJ. Sildenafil for male erectile dysfunction: A systematic review and meta-analysis. Arch Int Med 2002;162:1349-60.
10. Shabsigh R, Donatucci C, Costabile R, Perelman MA, Burns P, Zeigler H, Wong DG. Reliability of efficacy in men with erectile dysfunction treated with tadalafil once daily after initial success. Int J Impot Res 2010;22:1-8.
11. Schulman CC, Shen W, Stothard DR, Schmitt H. Integrated analysis examining first-dose success, success by dose, and maintenance of success among men taking tadalafil for erectile dysfunction. Urology 2004;64:783-8.
12. Valiquette L, Montorsi F, Auerbach S. Vardenafil demonstrates first-dose success and reliability of penetration and maintenance of erection in men with erectile dysfunction-RELY-II. Can Urol Assoc J 2008;2:187-95.
13. McCullough AR, Barada JH, Fawzy A, Guay AT, Hatzichristou D. Achieving treatment optimization with sildenafil citrate (Viagra) in patients with erectile dysfunction. Urology 2002;60:28-38.
14. Araujo AB, Allen KR, Ni X, Rosen RC. Minimal clinically important differences in the vaginal insertion and successful intercourse items of the sexual encounter profile. J Sex Med 2012;9:169-79.
15. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997;49:822-30.
16. Montorsi F, Salonia A, Briganti A, Barbieri L, Zanni G, Suardi N, Cestari A, Montorsi P, Rigatti P. Vardenafil for the treatment of erectile dysfunction: A critical review of the literature based on personal clinical experience. Eur Urol 2005;47:612-21.