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Volumn 47, Issue 5, 2005, Pages 612-621

Vardenafil for the treatment of erectile dysfunction: A critical review of the literature based on personal clinical experience

Author keywords

Erectile dysfunction; Phosphodiesterase type 5 inhibitors; Review; Vardenafil

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; CYTOCHROME P450 INHIBITOR; ERYTHROMYCIN; INDINAVIR; ITRACONAZOLE; KETOCONAZOLE; NITRATE; PHOSPHODIESTERASE V INHIBITOR; RITONAVIR; SILDENAFIL; TADALAFIL; TAMSULOSIN; VARDENAFIL;

EID: 17144376409     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2005.01.007     Document Type: Review
Times cited : (33)

References (39)
  • 1
    • 0035157613 scopus 로고    scopus 로고
    • The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil
    • I. Sáenz de Tejada, J. Angulo, P. Cuevas, A. Fernandez, I. Moncada, and A. Allona The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil Int J Impot Res 13 2001 282 290
    • (2001) Int J Impot Res , vol.13 , pp. 282-290
    • Sáenz De Tejada, I.1    Angulo, J.2    Cuevas, P.3    Fernandez, A.4    Moncada, I.5    Allona, A.6
  • 2
    • 0001825459 scopus 로고    scopus 로고
    • Selectivity of sildenafil and other phosphodiesterase type 5 (PDE5) inhibitors against all human phosphodiesterase families
    • E. Gbekor, S. Bethell, L. Fawcett, N. Mount, and S. Phillips Selectivity of sildenafil and other phosphodiesterase type 5 (PDE5) inhibitors against all human phosphodiesterase families Eur Urol 1 Suppl 1 2002 63
    • (2002) Eur Urol , vol.1 , Issue.SUPPL. 1 , pp. 63
    • Gbekor, E.1    Bethell, S.2    Fawcett, L.3    Mount, N.4    Phillips, S.5
  • 3
    • 0035964782 scopus 로고    scopus 로고
    • Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor
    • N.N. Kim, Y.H. Huang, I. Goldstein, E. Bischoff, and A.M. Trais Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor Life Sci 69 2001 2249 2256
    • (2001) Life Sci , vol.69 , pp. 2249-2256
    • Kim, N.N.1    Huang, Y.H.2    Goldstein, I.3    Bischoff, E.4    Trais, A.M.5
  • 4
    • 0035258442 scopus 로고    scopus 로고
    • Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: A RigiScan and pharmacokinetic study
    • T. Klotz, R. Sachse, A. Heidrich, F. Jockenhövel, G. Rohde, and G. Wensing Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: a RigiScan and pharmacokinetic study World J Urol 19 2001 32 39
    • (2001) World J Urol , vol.19 , pp. 32-39
    • Klotz, T.1    Sachse, R.2    Heidrich, A.3    Jockenhövel, F.4    Rohde, G.5    Wensing, G.6
  • 5
    • 17944364288 scopus 로고    scopus 로고
    • Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose
    • S. Stark, R. Sachse, T. Liedl, J. Hensen, G. Rohde, and G. Wensing Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose Eur Urol 40 2001 181 188
    • (2001) Eur Urol , vol.40 , pp. 181-188
    • Stark, S.1    Sachse, R.2    Liedl, T.3    Hensen, J.4    Rohde, G.5    Wensing, G.6
  • 6
    • 0037370684 scopus 로고    scopus 로고
    • Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction
    • P. Rajagopalan, A. Mazzu, C. Xia, R. Dawkins, and P. Sundaresan Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction J Clin Pharmacol 43 2003 260 267
    • (2003) J Clin Pharmacol , vol.43 , pp. 260-267
    • Rajagopalan, P.1    Mazzu, A.2    Xia, C.3    Dawkins, R.4    Sundaresan, P.5
  • 7
    • 0000674216 scopus 로고    scopus 로고
    • Effect of renal impairment on the single-dose pharmacokinetics of vardenafil 20 mg, a selective PDE5 inhibitor for the treatment of erectile dysfunction
    • T. Klotz, R.J. Bauer, and G. Rohde Effect of renal impairment on the single-dose pharmacokinetics of vardenafil 20 mg, a selective PDE5 inhibitor for the treatment of erectile dysfunction Pharmacotherapy 22 2002 418
    • (2002) Pharmacotherapy , vol.22 , pp. 418
    • Klotz, T.1    Bauer, R.J.2    Rohde, G.3
  • 8
    • 85030798391 scopus 로고    scopus 로고
    • http://www.emea.eu.int/humandocs/Humans/EPAR/levitra/levitra.htm
  • 9
    • 8544222158 scopus 로고    scopus 로고
    • Coadministered vardenafil for erectile dysfunction and tamsulosin do not induce hypotension in patients with benign prostatic hypertrophy
    • S. Auerbach, M. Gittelman, A. Mazzu, P. Sundaresan, and W. White Coadministered vardenafil for erectile dysfunction and tamsulosin do not induce hypotension in patients with benign prostatic hypertrophy Am J Hypertens 17 5 Suppl 1 2004 16A (abs OR35)
    • (2004) Am J Hypertens , vol.17 , Issue.5 SUPPL. 1
    • Auerbach, S.1    Gittelman, M.2    Mazzu, A.3    Sundaresan, P.4    White, W.5
  • 10
    • 0036868441 scopus 로고    scopus 로고
    • Vardenafil for treatment of men with erectile dysfunction: Efficacy and safety in a randomized, double-blind, placebo-controlled trial
    • on behalf of the Vardenafil Study Group T.
    • W.J.G. Hellstrom, M. Gittelman, G. Karlin, T. Segerson, M. Thibonnier, T. Taylor on behalf of the Vardenafil Study Group Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial J Androl 23 2002 763 771
    • (2002) J Androl , vol.23 , pp. 763-771
    • Hellstrom, W.J.G.1    Gittelman, M.2    Karlin, G.3    Segerson, T.4    Thibonnier, M.5    Taylor6
  • 11
    • 0042405173 scopus 로고    scopus 로고
    • Vardenafil, a new phosphodiesterase type 5 inhibitor in the treatment of erectile dysfunction in men with diabetes: A multicenter double-blind placebo-controlled fixed-dose study
    • I. Goldstein, J.M. Young, J. Fischer, K. Bangerter, T. Segerson, and T. Taylor Vardenafil, a new phosphodiesterase type 5 inhibitor in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study Diabetes Care 26 2003 777 783
    • (2003) Diabetes Care , vol.26 , pp. 777-783
    • Goldstein, I.1    Young, J.M.2    Fischer, J.3    Bangerter, K.4    Segerson, T.5    Taylor, T.6
  • 12
    • 0034868820 scopus 로고    scopus 로고
    • The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: The first at-home clinical trial
    • H. Porst, R. Rosen, H. Padma-Nathan, I. Goldstein, F. Giuliano, and E. Ulbrich The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial Int J Impot Res 13 2001 192 199
    • (2001) Int J Impot Res , vol.13 , pp. 192-199
    • Porst, H.1    Rosen, R.2    Padma-Nathan, H.3    Goldstein, I.4    Giuliano, F.5    Ulbrich, E.6
  • 13
    • 84995315685 scopus 로고    scopus 로고
    • Sustained efficacy and tolerability with vardenafil over 2 years of treatment in men with erectile dysfunction
    • C. Stief, H. Porst, S. de Tejada, E. Ulbrich, and M. Beneke Sustained efficacy and tolerability with vardenafil over 2 years of treatment in men with erectile dysfunction Int J Clin Pract 58 2004 230 239
    • (2004) Int J Clin Pract , vol.58 , pp. 230-239
    • Stief, C.1    Porst, H.2    De Tejada, S.3    Ulbrich, E.4    Beneke, M.5
  • 14
    • 0043194001 scopus 로고    scopus 로고
    • Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy
    • G. Brock, A. Nehra, L.I. Lipshultz, G.S. Karlin, M. Gleave, and M. Seger Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy J Urol 170 2003 1278 1283
    • (2003) J Urol , vol.170 , pp. 1278-1283
    • Brock, G.1    Nehra, A.2    Lipshultz, L.I.3    Karlin, G.S.4    Gleave, M.5    Seger, M.6
  • 15
    • 2942585404 scopus 로고    scopus 로고
    • Efficacy of vardenafil in men with erectile dysfunction: A flexible dose community practice study
    • on behalf of the Vardenafil Study Group M.
    • A.-J. Potempa, E. Ulbrich, I. Bernard, M. Beneke on behalf of the Vardenafil Study Group Efficacy of vardenafil in men with erectile dysfunction: A flexible dose community practice study Eur Urol 46 2004 73 79
    • (2004) Eur Urol , vol.46 , pp. 73-79
    • Potempa, A.-J.1    Ulbrich, E.2    Bernard, I.3    Beneke4
  • 16
    • 1842687262 scopus 로고    scopus 로고
    • The efficacy and safety of flexible-dose vardenafil (Levitra) in a broad population of European men
    • D. Hatzichristou, F. Montorsi, J. Buvat, N. Laferriere, T. Bandel, and H. Porst The efficacy and safety of flexible-dose vardenafil (Levitra) in a broad population of European men Eur Urol 45 2004 634 641
    • (2004) Eur Urol , vol.45 , pp. 634-641
    • Hatzichristou, D.1    Montorsi, F.2    Buvat, J.3    Laferriere, N.4    Bandel, T.5    Porst, H.6
  • 17
    • 19944373050 scopus 로고    scopus 로고
    • Erectile response with vardenafil in sildenafil non-responders: A multicentre, double-blind, 12-week, flexible-dose, placebo-controlled erectile dysfunction clinical trial
    • in press.
    • Carson CC, Hatzichristou DG, Carrier S, Lording D, Lyngdorf P, Aliotta P, et al. for the PROVEN Study Group. Erectile response with vardenafil in sildenafil non-responders: A multicentre, double-blind, 12-week, flexible-dose, placebo-controlled erectile dysfunction clinical trial. BJU Int 2004; in press.
    • (2004) BJU Int
    • Carson, C.C.1    Hatzichristou, D.G.2    Carrier, S.3    Lording, D.4    Lyngdorf, P.5    Aliotta, P.6
  • 18
    • 0036668536 scopus 로고    scopus 로고
    • The International Index of Erectile Function (IIEF): A state-of-the-science review
    • R.C. Rosen, J.C. Cappelleri, and N. Gendrano IIIrd The International Index of Erectile Function (IIEF): a state-of-the-science review Int J Impot Res 14 2002 226 244
    • (2002) Int J Impot Res , vol.14 , pp. 226-244
    • Rosen, R.C.1    Cappelleri, J.C.2    Iiird, G.N.3
  • 19
    • 0010958297 scopus 로고    scopus 로고
    • Long-term efficacy and safety of vardenafil in diabetic men with erectile dysfunction
    • I. Goldstein, J. Young, T. Segerson, and M. Thibonnier Long-term efficacy and safety of vardenafil in diabetic men with erectile dysfunction Diabetes 51 Suppl 2 2002 A98
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2 , pp. 98
    • Goldstein, I.1    Young, J.2    Segerson, T.3    Thibonnier, M.4
  • 20
    • 1842852557 scopus 로고    scopus 로고
    • Effects of tadalafil on erectile dysfunction in men with diabetes
    • I. Saenz de Tejada, G. Anglin, J.R. Knight, and J.T. Emmick Effects of tadalafil on erectile dysfunction in men with diabetes Diabetes Care 25 2002 2159 2164
    • (2002) Diabetes Care , vol.25 , pp. 2159-2164
    • Saenz De Tejada, I.1    Anglin, G.2    Knight, J.R.3    Emmick, J.T.4
  • 21
    • 2942676725 scopus 로고    scopus 로고
    • Oral sildenafil in the treatment of erectile dysfunction in diabetic men: A randomized double-blind and placebo-controlled study
    • M.R. Safarinejad Oral sildenafil in the treatment of erectile dysfunction in diabetic men: a randomized double-blind and placebo-controlled study J Diabetes Complications 18 2004 205 210
    • (2004) J Diabetes Complications , vol.18 , pp. 205-210
    • Safarinejad, M.R.1
  • 22
    • 17144367411 scopus 로고    scopus 로고
    • Efficacy and tolerability of vardenafil in men with erectile dysfunction and residual tumescence following radical retropubic prostatectomy
    • J. Grantmyre, G. Brock, A. Nadel, and M. Seger Efficacy and tolerability of vardenafil in men with erectile dysfunction and residual tumescence following radical retropubic prostatectomy J Andrology SS 2004 58 (abstract 61)
    • (2004) J Andrology , pp. 58
    • Grantmyre, J.1    Brock, G.2    Nadel, A.3    Seger, M.4
  • 23
    • 0242484067 scopus 로고    scopus 로고
    • Post-operative nightly administration of sildenafil citrate significantly improves the return of normal spontaneous erectile function after bilateral nerve-sparing radical prostatectomy
    • H. Padma-Nathan, A.R. McCullough, F. Giuliano, S.M. Toler, and C. Wohlhuter Post-operative nightly administration of sildenafil citrate significantly improves the return of normal spontaneous erectile function after bilateral nerve-sparing radical prostatectomy J Urol 4 Suppl 2003 169 abstract 1402
    • (2003) J Urol , vol.4 , Issue.SUPPL. , pp. 169
    • Padma-Nathan, H.1    McCullough, A.R.2    Giuliano, F.3    Toler, S.M.4    Wohlhuter, C.5
  • 24
    • 4043132654 scopus 로고    scopus 로고
    • Efficacy and tolerability of vardenafil in men with mild major depressive disorder and erectile dysfunction: The Depression Related Improvement with Vardenafil for Erectile Response (DRIVER) study
    • R. Rosen, F. Montorsi, P. Assalian, L. Rodriguez-Vela, R. Porto, and K. Bangerter Efficacy and tolerability of vardenafil in men with mild major depressive disorder and erectile dysfunction: the Depression Related Improvement with Vardenafil for Erectile Response (DRIVER) study Eur Urol 3 2004 235 (LB14)
    • (2004) Eur Urol , vol.3 , pp. 235
    • Rosen, R.1    Montorsi, F.2    Assalian, P.3    Rodriguez-Vela, L.4    Porto, R.5    Bangerter, K.6
  • 25
    • 17144401947 scopus 로고    scopus 로고
    • Time course of erectile function and depression intensity improvement in men with mild major depressive disorder and erectile dysfunction after treatment with vardenafil
    • A. Shabsigh, R. Porto, and I. Goldstein Time course of erectile function and depression intensity improvement in men with mild major depressive disorder and erectile dysfunction after treatment with vardenafil Sexual and Relationship Therapy 19 Suppl 1 2004 S67 (abstract 326)
    • (2004) Sexual and Relationship Therapy , vol.19 , Issue.SUPPL. 1 , pp. 67
    • Shabsigh, A.1    Porto, R.2    Goldstein, I.3
  • 26
    • 4544247613 scopus 로고    scopus 로고
    • Earliest time of onset of erections with vardenafil determined in an at-home setting
    • H. Padma-Nathan, J. Kaufman, and T. Taylor Earliest time of onset of erections with vardenafil determined in an at-home setting J Androl 24 2003 48 (abstract 41)
    • (2003) J Androl , vol.24 , pp. 48
    • Padma-Nathan, H.1    Kaufman, J.2    Taylor, T.3
  • 27
    • 20144384484 scopus 로고    scopus 로고
    • Earliest time to onset of action leading to successful intercourse with vardenafil determined in an at-home setting: A randomised, double-blind, placebo-controlled trial
    • for the Vardenafil Study Group E.
    • F. Montorsi, H. Padma-Nathan, J. Buvat, H. Schwaibold, M. Beneke, E. Ulbrich for the Vardenafil Study Group Earliest time to onset of action leading to successful intercourse with vardenafil determined in an at-home setting: A randomised, double-blind, placebo-controlled trial J Sex Med 1 2004 168 178
    • (2004) J Sex Med , vol.1 , pp. 168-178
    • Montorsi, F.1    Padma-Nathan, H.2    Buvat, J.3    Schwaibold, H.4    Beneke, M.5    Ulbrich6
  • 28
    • 3343005292 scopus 로고    scopus 로고
    • Vardenafil preclinical trial data: Potency, pharmacodynamics, pharmacokinetics and adverse events
    • E. Bischoff Vardenafil preclinical trial data: Potency, pharmacodynamics, pharmacokinetics and adverse events Int J Impot Res 16 Suppl 1 2004 S34 S37
    • (2004) Int J Impot Res , vol.16 , Issue.SUPPL. 1
    • Bischoff, E.1
  • 29
    • 3042574999 scopus 로고    scopus 로고
    • Binding of titrated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation
    • M.A. Blount, A. Beasley, R. Zoraghi, K.R. Sekhar, E.P. Bessay, and S.H. Francis Binding of titrated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation Mol Pharmacol 66 2004 144 152
    • (2004) Mol Pharmacol , vol.66 , pp. 144-152
    • Blount, M.A.1    Beasley, A.2    Zoraghi, R.3    Sekhar, K.R.4    Bessay, E.P.5    Francis, S.H.6
  • 30
    • 85030798512 scopus 로고    scopus 로고
    • Vardenafil (Levitra®) improves maintenance success rates from within 15 minutes to up to 12 hours from time of dosing to start of sexual activity. Poster presented Prague, Czech Republic, February 26-29
    • Stief C, Valiquette L, Montorsi F, Hellstrom W, Giuliano F, Homering M, et al. Vardenafil (Levitra®) improves maintenance success rates from within 15 minutes to up to 12 hours from time of dosing to start of sexual activity. Poster presented at the World Congress on the Aging Male, Prague, Czech Republic, February 26-29, 2004.
    • (2004) World Congress on the Aging Male
    • Stief, C.1    Valiquette, L.2    Montorsi, F.3    Hellstrom, W.4    Giuliano, F.5    Homering, M.6
  • 32
    • 0142121889 scopus 로고    scopus 로고
    • Cardiovascular safety of vardenafil in patients receiving antihypertensive medications: A post-hoc analysis of five placebo-controlled clinical trials
    • R. Kloner, P. Mohan, T. Segerson, M. Thibonnier, C. Norenberg, and H. Padma-Nathan Cardiovascular safety of vardenafil in patients receiving antihypertensive medications: a post-hoc analysis of five placebo-controlled clinical trials J Am Coll Cardiol 41 2003 276A (A-120)
    • (2003) J Am Coll Cardiol , vol.41
    • Kloner, R.1    Mohan, P.2    Segerson, T.3    Thibonnier, M.4    Norenberg, C.5    Padma-Nathan, H.6
  • 33
    • 12444311195 scopus 로고    scopus 로고
    • Cardiovascular safety of the selective PDE5 inhibitor vardenafil in patients with erectile dysfunction: An analysis of five placebo-controlled clinical trials
    • R.A. Kloner, H. Porst, P. Mohan, C. Norenberg, K. Pomerantz, and T. Segerson Cardiovascular safety of the selective PDE5 inhibitor vardenafil in patients with erectile dysfunction: an analysis of five placebo-controlled clinical trials Int J Impot Res 14 Suppl 4 2002 S22
    • (2002) Int J Impot Res , vol.14 , Issue.SUPPL. 4 , pp. 22
    • Kloner, R.A.1    Porst, H.2    Mohan, P.3    Norenberg, C.4    Pomerantz, K.5    Segerson, T.6
  • 34
    • 0037021566 scopus 로고    scopus 로고
    • The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease
    • U. Thadani, W. Smith, S. Nash, N. Bittar, S. Glasser, and P. Narayan The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease J Am Coll Cardiol 40 2002 2006 2012
    • (2002) J Am Coll Cardiol , vol.40 , pp. 2006-2012
    • Thadani, U.1    Smith, W.2    Nash, S.3    Bittar, N.4    Glasser, S.5    Narayan, P.6
  • 35
    • 17144424727 scopus 로고    scopus 로고
    • The effect of 20 mg Levitra (vardenafil) on ischemic threshold, exercise tolerance, and circulatory responses during treadmill exercise in men with stable angina pectoris
    • and the Vardenafil Study Group A.
    • U. Thadani, A. Mazzu and the Vardenafil Study Group The effect of 20 mg Levitra (vardenafil) on ischemic threshold, exercise tolerance, and circulatory responses during treadmill exercise in men with stable angina pectoris Can J Cardiol 19 Suppl A 2003 252A
    • (2003) Can J Cardiol , vol.19 , Issue.SUPPL. A
    • Thadani, U.1    Mazzu2
  • 39
    • 0034045724 scopus 로고    scopus 로고
    • Management of sexual dysfunction in patients with cardiovascular disease: Recommendations of the Princeton Consensus Panel
    • R. DeBusk, U. Drory, and I. Goldstein Management of sexual dysfunction in patients with cardiovascular disease: Recommendations of the Princeton Consensus Panel Am J Cardiol 86 2000 175 181
    • (2000) Am J Cardiol , vol.86 , pp. 175-181
    • Debusk, R.1    Drory, U.2    Goldstein, I.3


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