Human papilloma virus (HPV) E7-Mediated attenuation of retinoblastoma (Rb) induces hPygopus2 expression via Elf-1 in cervical cancer

Molecular Cancer Research

Volumn 11, Issue 1, 2013, Pages 19-30

  Tzenov, Youlian R ^a   Andrews, Phillip G ^a   Voisey, Kim ^b   Popadiuk, Paul ^c   Xiong, Jieying ^a   Popadiuk, Catherine ^a   Kao, Kenneth R ^a,b  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b Eastern Health Canada   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; HUMAN PAPILLOMAVIRUS E7 PROTEIN; HUMAN PYGOPUS 2; MESSENGER RNA; TRANSCRIPTION FACTOR ELF 1; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETINOBLASTOMA; RNA INTERFERENCE; UTERINE CERVIX CANCER;

CELL LINE, TUMOR; CELL TRANSFORMATION, VIRAL; EPHRIN-A2; FEMALE; HUMAN PAPILLOMAVIRUS 16; HUMAN PAPILLOMAVIRUS 18; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PAPILLOMAVIRUS E7 PROTEINS; PAPILLOMAVIRUS INFECTIONS; RETINOBLASTOMA PROTEIN; TRANSFECTION; UTERINE CERVICAL NEOPLASMS;

EID: 84873054456     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-12-0510     Document Type: Article

References (49)

1. Jessen S, Gu B, Dai X. Pygopus and the Wnt signaling pathway: a diverse set of connections. Bioessays 2008;30:448-56.
2. Popadiuk CM, Xiong J, Wells MG, Andrews PG, Dankwa K, Hirasawa K, et al. Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer. Clin Cancer Res 2006;12:2216-23.
3. Andrews PG, Lake BB, Popadiuk C, Kao KR. Requirement of Pygopus 2 in breast cancer. Int J Oncol 2007;30:357-63.
4. Chen J, Luo Q, Yuan Y, Huang X, Cai W, Li C, et al. Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol Cell Biol 2010;30: 5621-35.
5. Wang ZX, Chen YY, Li BA, Tan GW, Liu XY, Shen SH, et al. Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth. J Neurooncol 2010;100:31-41.
6. Chen YY, Li BA, Wang HD, Liu XY, Tan GW, Ma YH, et al. The role of Pygopus 2 in rat glioma cell growth. Med Oncol 2011;28:631-40.
7. Andrews PG, Kennedy MW, Popadiuk CM, Kao KR. Oncogenic activation of the human Pygopus2 promoter by E74-like factor-1. Mol Cancer Res 2008;6:259-66.
8. Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 2005;41:2462-78.
9. Zhu JD, Fei Q, WangP, Lan F, Maod Q, Zhang HY, et al. Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site. Cell Res 2006;16: 780-96.
10. Huang X, Brown C, Ni W, Maynard E, Rigby AC, Oettgen P. Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesis. Blood 2006;107:3153-60.
11. Hegen A, Koidl S, Weindel K, Marme D, Augustin HG, Fiedler U. Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements. Arterioscler Thromb Vasc Biol 2004;24:1803-9.
12. Scott GK, Chang CH, Erny KM, Xu F, Fredericks WJ, Rauscher FJ III, et al. Ets regulation of the erbB2 promoter. Oncogene 2000;19:6490- 502.
13. Nicol AF, Pires AR, de Souza SR, Nuovo GJ, Grinsztejn B, Tristao A, et al. Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA). BMC Cancer 2008;8:289.
14. Gavrilov D, Kenzior O, Evans M, Calaluce R, Folk WR. Expression of urokinase plasminogen activator and receptor in conjunction with the ets family and AP-1 complex transcription factors in high grade prostate cancers. Eur J Cancer 2001;37:1033-40.
15. Bassuk AG, Barton KP, Anandappa RT, Lu MM, Leiden JM. Expression pattern of the Ets-related transcription factor Elf-1. Mol Med 1998;4:392-401.
16. Sahin A, Vercamer C, Kaminski A, Fuchs T, Florin A, Hahne JC, et al. Dominant-negative inhibition of Ets 1 suppresses tumor growth, invasion and migration in rat C6 glioma cells and reveals differentially expressed Ets 1 target genes. Int J Oncol 2009;34:377-89.
17. Yang DX, Li NE, MaY, Han YC, Shi Y. Expression of Elf-1 and survivin in non-small cell lung cancer and their relationship to intratumoral microvessel density. Chin J Cancer 2010;29:396-402.
18. Yang DX, Han YC, Liu LY, Yu N, Wang X, Shi Y. [Expression and significance of Elf-1 and vascular endothelial growth factor in nonsmall cell lung cancer]. Ai Zheng 2009;28:762-7.
19. Takai N, Ueda T, Nishida M, Nasu K, Miyakawa I. The relationship between oncogene expression and clinical outcome in endometrial carcinoma. Curr Cancer Drug Targets 2004;4:511-20.
20. Takai N, Miyazaki T, Nishida M, Nasu K, Miyakawa I. The significance of Elf-1 expression in epithelial ovarian carcinoma. Int J Mol Med 2003;12:349-54.
21. Wang CY, Petryniak B, Thompson CB, Kaelin WG, Leiden JM. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. Science 1993;260:1330-5.
22. Moody CA, Laimins LA. Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer 2010;10:550-60.
23. Pahel G, Aulabaugh A, Short SA, Barnes JA, Painter GR, Ray P, et al. Structural and functional characterization of the HPV16 E7 protein expressed in bacteria. J Biol Chem 1993;268:26018-25.
24. Hawley-Nelson P, Vousden KH, Hubbert NL, Lowy DR, Schiller JT. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J 1989;8:3905-10.
25. Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, et al. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci U S A 1992; 89:4549-53.
26. Schwarz E, Freese UK, Gissmann L, Mayer W, Roggenbuck B, Stremlau A, et al. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 1985;314: 111-4.
27. Huibregtse JM, Scheffner M, Howley PM. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J 1991;10:4129-35.
28. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-36.
29. Munger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J 1989;8: 4099-105.
30. Tsutsumi K, Belaguli N, Qi S, Michalak TI, Gulliver WP, Pater A, et al. Human papillomavirus 16 DNA immortalizes two types of normal human epithelial cells of the uterine cervix. Am J Pathol 1992;140: 255-61.
31. Yokoyama M, Tsutsumi K, Pater A, Pater MM. Human papillomavirus 18-immortalized endocervical cells with in vitro cytokeratin expression characteristics of adenocarcinoma. Obstet Gynecol 1994;83:197- 204.
32. Yang X, Nakao Y, Pater MM, Pater A. Identification of two novel cellular genes associated with multistage carcinogenesis of human endocervical cells by mRNA differential display. Carcinogenesis 1996;17: 563-7.
33. Nakao Y, Yang X, Yokoyama M, Pater MM, Pater A. Malignant transformation of human ectocervical cells immortalized by HPV 18: in vitro model of carcinogenesis by cigarette smoke. Carcinogenesis 1996;17:577-83.
34. Chang JT, Kuo TF, Chen YJ, Chiu CC, Lu YC, Li HF, et al. Highly potent and specific siRNAs against E6 or E7 genes of H. Cancer Gene Ther 2010;17:827-36.
35. Hamel PA, Gill RM, Phillips RA, Gallie BL. Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression. Oncogene 1992;7:693-701.
36. Balan R, Giusca S, Caruntu ID, Gheorghita V, Neacsu D, Amalinei C. Immunochemical assessment of p16 and HPV L1 capsid protein in cervical squamous intraepithelial lesions. Rev Med Chir Soc Med Nat Iasi 2010;114:1118-24.
37. Yu CC, Filipe MI. Update on proliferation-associated antibodies applicable to formalin-fixed paraffin-embedded tissue and their clinical applications. Histochem J 1993;25:843-53.
38. Gupta N, Srinivasan R, Rajwanshi A. Functional biomarkers in cervical precancer: an overview. Diagn Cytopathol 2010;38:618-23.
39. Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M. A new nuclear component of the Wnt signalling pathway. Nat Cell Biol 2002;4:367-73.
40. Waldman T, Kinzler KW, Vogelstein B. p21 is necessary for the p53- mediated G1 arrest in human cancer cells. Cancer Res 1995;55: 5187-90.
41. Jin E, Liu J, Suehiro J, Yuan L, Okada Y, Nikolova-Krstevski V, et al. Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo. Blood 2009;114: 5557-66.
42. Scott GK, Daniel JC, Xiong X, Maki RA, Kabat D, Benz CC. Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells. J Biol Chem 1994;269:19848-58.
43. Strobeck MW, Knudsen KE, Fribourg AF, DeCristofaro MF, Weissman BE, Imbalzano AN, et al. BRG-1 is required for RB-mediated cell cycle arrest. Proc Natl Acad Sci USA 2000;97:7748-53.
44. Uren A, Fallen S, Yuan H, Usubutun A, Kucukali T, Schlegel R, et al. Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression. Cancer Res 2005;65:6199-206.
45. Mosimann C, Hausmann G, Basler K. Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol 2009;10:276-86.
46. Iljin K, Dube A, Kontusaari S, Korhonen J, Lahtinen I, Oettgen P, et al. Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter. FASEB J 1999;13: 377-86.
47. Choi HJ, Geng Y, Cho H, Li S, Giri PK, Felio K, et al. Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells. Blood 2011;117:1880-7.
48. Seth A, Watson DK, Blair DG, Papas TS. c-ets-2 protooncogene has mitogenic and oncogenic activity. Proc Natl Acad Sci USA 1989; 86:7833-7.
49. Leiden JM, Wang CY, Petryniak B, Markovitz DM, Nabel GJ, Thompson CB. A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. J Virol 1992;66:5890-7.