Adrenalectomy amplifies aldosterone induced injury in cardiovascular tissue: An effect attenuated by adrenally derived steroids

Steroids

Volumn 78, Issue 3, 2013, Pages 347-355

  Brem, Andrew S ^a   Morris, David J ^a   Li, Xiangpo ^a   Ge, Yan ^a   Shaw, Sunil ^b   Gong, Rujun ^a  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

11 Hydroxysteroid dehydrogenase; 11 Dehydrocorticosterone; Fibrosis; Inflammation; Mineralocorticoids; Vascular endothelial cells

Indexed keywords

ALDOSTERONE; COLLAGEN; CORTICOSTERONE; DEHYDROCORTICOSTERONE; MINERALOCORTICOID ANTAGONIST; RU 318; UNCLASSIFIED DRUG;

ADRENALECTOMY; ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CELL ADHESION; CONTROLLED STUDY; CORONARY BLOOD VESSEL; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HEART; HEART WEIGHT; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; KIDNEY INJURY; MALE; MONOCYTE; MOUSE; NONHUMAN; SMOOTH MUSCLE; TISSUE INJURY; VASCULAR FIBROSIS; VASCULAR TISSUE;

ADRENAL GLANDS; ADRENALECTOMY; ALDOSTERONE; ANIMALS; AORTA; BLOOD PRESSURE; BODY WEIGHT; CELL ADHESION; COLLAGEN; CORTICOSTERONE; E-SELECTIN; GENE EXPRESSION; HEART; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MINERALOCORTICOID RECEPTOR ANTAGONISTS; MONOCYTES; TUNICA INTIMA;

ANIMALIA; MUS;

EID: 84873054240     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.12.007     Document Type: Article

References (36)

1. C.G. Brilla, and K.T. Weber Mineralocorticoid excess, dietary sodium, and myocardial fibrosis J Lab Clin Med 120 1992 893 901
2. M. Young, M. Fullerton, R. Dilley, and J. Funder Mineralocorticoids, hypertension, and cardiac fibrosis J Clin Invest 93 1994 2578 2583
3. E.L. Greene, S. Kren, and T.H. Hostetter Role of aldosterone in the remnant kidney model in the rat J Clin Invest 98 1996 1063 1068
4. Y. Sun, F.J. Ramires, and K.T. Weber Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion Cardiovasc Res 35 1997 138 147
5. R. Rocha, C.T. Stier Jr., and I. Kifor Aldosterone: a mediator of myocardial necrosis and renal arteriopathy Endocrinology 141 2000 3871 3878
6. N.J. Brown, S. Nakamura, and L. Ma Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo Kidney Int 58 2000 1219 1227
7. V. Leroy, S. De Seigneux, and V. Agassiz Aldosterone activates NF-kappaB in the collecting duct J Am Soc Nephrol 20 2009 131 144 Epub 2008 Nov 5
8. V. Vallon, A.W. Wyatt, and K. Klingel SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment J Mol Med 84 2006 396 404 Epub 2006 Apr 8
9. O.G. Muller, R.G. Parnova, and G. Centeno Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+ J Am Soc Nephrol 14 2003 1107 1115
10. A. Naray-Fejes-Toth, M.N. Helms, J.B. Stokes, and G. Fejes-Toth Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies Mol Cell Endocrinol 217 2004 197 202
11. A.S. Brem, D.J. Morris, and Y. Ge Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11{beta}-HSD activity Am J Physiol Renal Physiol 298 2010 F1178 F1187
12. A.C. Barger, R.D. Berlin, and J.F. Tulenko Infusion of aldosterone, 9-alpha-fluorohydrocortisone, and antidiuretic hormone into the renal artery of normal and adrenalectomized unanesthetized dogs: effect on electrolyte and water excretion Endocrinology 62 1958 804 815
13. E.J. Ross Modification of the effects of aldosterone on electrolyte excretion in man by simultaneous administration of corticosterone and hydrocortisone. Relevance to Conn's syndrome J Clin Endocrinol Metab 20 1960 229 237
14. D.J. Morris, J.S. Berek, and R.P. Davis The physiological response to aldosterone in adrenalectomized and intact rats and its sex dependence Endocrinology 92 1973 989 993
15. G.A. Porter, R. Bogoroch, and I.S. Edelman On the mechanism of action of aldosterone on sodium transport: the role of RNA synthesis Proc Natl Acad Sci USA 52 1964 1326 1333
16. N. Farman, M. Kusch, and I.S. Edelman Aldosterone receptor occupancy and sodium transport in the urinary bladder of Bufo marinus Am J Physiol 235 1978 C90 C96
17. K.G.M.M. Alberti, and G.W.G. Sharp Identification of four types of steroid by their interaction with mineralocorticoid receptors in the toad bladder J Endocrinol 48 1970 563 574
18. A.S. Brem, K.L. Matheson, J.L. Barnes, and D.J. Morris 11-Dehydrocorticosterone, a glucocorticoid metabolite, inhibits aldosterone action in toad bladder Am J Physiol 261 1991 F873 F879
19. A. Odermatt, P. Arnold, and F.J. Frey The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2 J Biol Chem 276 2001 28484 28492 Epub 2001 May 11
20. M.J. Young, J. Morgan, and K. Brolin Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats Endocrinology 151 2010 2622 2628 Epub 2010 Apr 21
21. M. Young, G. Head, and J. Funder Determinants of cardiac fibrosis in experimental hypermineralocorticoid states Am J Physiol 269 1995 E657 E662
22. R. Rocha, C.L. Martin-Berger, and P. Yang Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart Endocrinology 143 2002 4828 4836
23. A.S. Brem, R.B. Bina, T.C. King, and D.J. Morris Localization of 2 11beta-OH steroid dehydrogenase isoforms in aortic endothelial cells Hypertension 31 1998 459 462
24. W.G. Sippell, H.G. Dorr, F. Bidlingmaier, and D. Knorr Plasma levels of aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, cortisol, and cortisone during infancy and childhood Pediatr Res 14 1980 39 46
25. K.E. Mickelson, J. Forsthoefel, and U. Westphal Steroid-protein interactions. Human corticosteroid binding globulin: some physicochemical properties and binding specificity Biochemistry 20 1981 6211 6218
26. J.Y. Daniel, F. Leboulenger, and H. Vaudry Interrelations between binding affinity and metabolic clearance rate for the main corticosteroids in the rabbit J Steroid Biochem 16 1982 379 384
27. J.R. Ingelfinger Forestalling fibrosis N Engl J Med 349 2003 2265 2266
28. R. Gong, A. Rifai, and E.M. Tolbert Hepatocyte growth factor modulates matrix metalloproteinases and plasminogen activator/plasmin proteolytic pathways in progressive renal interstitial fibrosis J Am Soc Nephrol 14 2003 3047 3060
29. C.E. Gomez-Sanchez, A.F. de Rodriguez, and D.G. Romero Development of a panel of monoclonal antibodies against the mineralocorticoid receptor Endocrinology 147 2006 1343 1348 Epub 2005 Nov 17
30. R. Gong, D.J. Morris, and A.S. Brem Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cells Steroids 73 2008 1187 1196 Epub 2008 Jun 3
31. H. Selye Anticortisol action of aldosterone Science 121 1955 368 369
32. R. Rocha, A.E. Rudolph, and G.E. Frierdich Aldosterone induces a vascular inflammatory phenotype in the rat heart Am J Physiol Heart Circ Physiol 283 2002 H1802 H1810
33. S. Reungjui, H. Hu, and W. Mu Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia Kidney Int 72 2007 1483 1492 Epub 2007 Oct 10
34. H. Ikeda, K. Tsuruya, and J. Toyonaga Spironolactone suppresses inflammation and prevents L-NAME-induced renal injury in rats Kidney Int 75 2009 147 155 Epub 2008 Oct 15
35. J.W. Funder, P.T. Pearce, R. Smith, and A.I. Smith Mineralocorticord action: target tissue specificity is enzyme, not receptor, mediated Science 242 1988 583 585
36. K. Miyata, M. Rahman, and T. Shokoji Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells J Am Soc Nephrol 16 2005 2906 2912 Epub 2005 Aug 31