A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status

Journal of Nutrition

Volumn 143, Issue 2, 2013, Pages 142-147

  Hill, Marilyn H ^a   Flatley, Janet E ^a   Barker, Margo E ^a   Garner, Clare M ^a   Manning, Nigel J ^b   Olpin, Simon E ^b   Moat, Stuart J ^c   Russell, Jean ^b   Powers, Hilary J ^a  

^a Faculty of Medicine Dentistry and Health   (United Kingdom)

^b SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COBALAMIN; CREATININE; CYANOCOBALAMIN; HOLOTRANSCOBALAMIN; METHYLMALONIC ACID; PLACEBO; UNCLASSIFIED DRUG;

AGED; AGING; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROSS-SECTIONAL STUDY; CYANOCOBALAMIN DEFICIENCY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SMOKING; TREATMENT DURATION; VITAMIN SUPPLEMENTATION;

AGED; AGED, 80 AND OVER; AGING; APOPROTEINS; BIOLOGICAL MARKERS; CREATININE; CROSS-SECTIONAL STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METHYLMALONIC ACID; NUTRITIONAL STATUS; PATIENT COMPLIANCE; SMOKING; TIME FACTORS; TRANSCOBALAMINS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84873049926     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.169193     Document Type: Article

References (33)

1. Ruston D, Hoare J, Henderson L, Gregory J, Bates CJ, Prentice A, Birch M, Swan G, Farron M. The National Diet and Nutrition Survey: adults aged 19 to 64 years. 4th vol. Nutritional status. London: HMSO; 2004.
2. Finch S, DoyleW, Lowe C, Bates CJ, Prentice A, Smithers G, Clarke PC. The National Diet and Nutrition Survey: people aged 65 years and over. London: HMSO; 1998.
3. Clarke R, Refsum H, Birks J, Evans JG, Johnston C, Sherliker P, Ueland PM, Schneede J, PcPartlin J, Nexo E, et al. Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr. 2003;77:1241-7.
4. Hirsch S, de la Maza P, Barrera G, Gattas V, Pettermann M, Bunout D. The Chilean flour folic acid fortification program reduced serum homocysteine levels and masks vitamin B12 deficiency in elderly people. J Nutr. 2002;132:289-91.
5. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anaemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr. 2007;85:193-200.
6. Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency. II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol. 1990;34:99-107.
7. Wald NJ, Law M, Hoffbrand VA. Vitamin B-12 and folate deficiency in elderly persons. Am J Clin Nutr. 2004;79:338; author reply 338-9.
8. Matchar DB, McCrory DC, Millington DS, Feussner JR. Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. Am J Med Sci. 1994;308:276-83.
9. Hvas AM, Nexo E. Holotranscobalamin; a first choice assay for diagnosing early vitamin B12 deficiency? J Intern Med. 2005;257:289-98.
10. Herrmann W, Obeid R, Schorr H, Geisel J. Functional vitamin B-12 deficiency and determination of holotranscobalamin in populations at risk. Clin Chem Lab Med. 2003;41:1478-88.
11. Herrmann W, Obeid R, Schorr H, Geisel J. The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings. Curr Drug Metab. 2005;6:47-53.
12. Flatley JE, Garner CM, Al-Turki M, Manning NJ, Olpin SE, Barker ME, Powers HJ. Determinants of urinary methylmalonic acid concentration in an elderly population in the United Kingdom. Am J Clin Nutr. 2012;95:686-93.
13. Bolann BJ, Solli JD, Schneede J, Grottum KA, Loraas A, Stokkeland M, Stallemo A, Schjoth A, Bie RB, Refsum H, et al. Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduction in increased serum methylmalonic acid. Clin Chem. 2000;46:1744-50.
14. Gültepe M, Ozcan O, Avsar K, Cetin M, Ozdemir AS, Gok M. Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders. Clin Biochem. 2003;36: 275-82.
15. Kwok T, Cheng G, Lai WK, Poon P, Woo J, Pang CP. Use of fasting urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older persons. Nutrition. 2004;20:764-8.
16. Norman EJ, Morrison JA. Screening elderly populations for cobalamin (vitamin B12) deficiency using the urinary methylmalonic acid assay by gas chromatography mass spectrometry. Am J Med. 1993;94:589-94.
17. Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr. 1999;70:904-10.
18. National Diet and Nutrition Survey: headline results from years 1 and 2 (combined) of the rolling programme, 2008/09-2009/10; supplementary report: blood analytes [cited 2012 Feb]. Available from: http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsStatistics/DH_130728accessed 28/09/2012.
19. Rajan S, Wallace JI, Brodkin KI, Beresford SA, Allen RH, Stabler SP. Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults. J Am Geriatr Soc. 2002;50:1789-95.
20. Eussen SJ, de Groot LC, Clarke R, Schneede J, Ueland PM, Hoefnagels WHL, van Staveren WA. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med. 2005;165:1167-72.
21. Rasmussen K. Studies on methylmalonic acid in humans. I. Concentrations in serum and urinary excretion in normal subjects after feeding and during fasting, and after loading with protein, fat, sugar, isoleucine and valine. Clin Chem. 1989;35:2271-6.
22. Rasmussen K. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem. 1989;35:260-4.
23. Clarke R, Grimley-Evans J, Schneede J, Nexo E, Bates CJ, Fletcher A, Prentice A, Johnston C, Ueland PM, Refsum H, et al. Vitamin B12 and folate deficiency in later life. Age Ageing. 2004;33:34-41.
24. Loikas S, Lopponen M, Suominen P, Moller J, Irjala K, Isoaho R, Kivela SL, Koskinen P, Pelliniemi TT. RIA for serum holo-transcobalamin: method evaluation in the clinical laboratory and reference interval. Clin Chem. 2003;49:455-62.
25. Allen LH. Bioavailability of vitamin B-12. Int J Vitam Nutr Res. 2010;80:330-5.
26. Dhonukshe-Rutten RAM, van Zutphen M, de Groot LCPGM, Eussen SJPM, Blom HJ, van Staveren WA. Effects of supplementation with cobalamin carried either by a milk product or a capsule in mildly cobalamin-deficient elderly Dutch persons. Am J Clin Nutr. 2005;82: 568-74.
27. Blacher J, Czernichow S, Raphael M, Roussel C, Chadefaux-Vekemens B, Morineau G, Giraidier S, Tibi A, Henry O, Vayssiere M, et al. Very low oral doses of vitamin B-12 increase serum concentrations in elderly subjects with food-bound vitamin B-12 malabsorption. J Nutr. 2007;137:373-8.
28. Carmel R. Efficacy and safety of fortification and supplementation with vitamin B-12: biochemical and physiological effects. Food Nutr Bull. 2008;29 Suppl 2:S177-87.
29. DeGrazia JA, Fish MB, Looycove M, Wallerstein RO, Hollander L. The role of propionate as a precursor of methylmalonic acid in normal and vitamin B-12 deficient man. J Lab Clin Med. 1969;73:917-23.
30. Wong JM, de Souza R, Kendall CW, Emam J, Jenkins DJ. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006;40:235-43.
31. Cullen RW, Oace SM. Fermentable dietary fiber elevates urinary methylmalonate and decreases propionate oxidation in rats deprived of vitamin B12. J Nutr. 1989;119:1115-20.
32. Finney H, Newman DJ, Price CP. Adult reference ranges for serum cystatin, creatinine and predicted creatinine clearance. Ann Clin Biochem. 2000;37:49-59.
33. Hoey L, Strain JJ, McNulty H. Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomised controlled trials. Am J Clin Nutr. 2009;89 Suppl:S1981-96.