Are epigenetic mechanisms involved in radiation-induced bystander effects

Frontiers in Genetics

Volumn 3, Issue MAY, 2012, Pages

  Mothersill, Carmel ^a   Seymour, Colin ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Bystander effects; Evolution; Genomic instability; Non targeted effects; Radiation

Indexed keywords

BACTERIA (MICROORGANISMS);

EID: 84873048811     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00074     Document Type: Short Survey

References (41)

1. Bréchignac, F., Bradshaw, C., Carroll, S., Jaworska, A., Kapustka, L., Monte, L., and Oughton, D. (2011). Recommendations from the International Union of Radioecology to improve guidance on radiation protection. Integr. Environ. Assess. Manag. 7, 411-413.
2. Calabrese, E. J., Stanek, E. J. III, and Nascarella, M. A. (2011). Evidence for hormesis in mutagenicity dose-response relationships. Mutat. Res. 726, 91-97.
3. Calvanese, V., Lara, E., and Fraga, M. F. (2012). Epigenetic code and self-identity. Adv. Exp. Med. Biol. 738, 236-255.
4. Hall, E. J., and Giaccia, A. J. (2006). Radiobiology for the Radiologist, 6th Edn. Philadelphia: Lippincott, Williams and Wilkins.
5. Hamada, N., Maeda, M., Otsuka, K., and Tomita, M. (2011). Sig naling pathways underpinning the manifestations of ionizing radiation-induced bystander effects. Curr. Mol. Pharmacol. 4, 79-95.
6. Hei,T.K.,Zhou,H.,Ivanov,V.N.,Hong, M., Lieberman, H. B., Brenner, D. J., Amundson, S. A., and Geard, C. R. (2008). Mechanism of radiation-induced bystander effects: a unifying model. J. Pharm. Pharmacol. 60, 943-950.
7. Ilnytskyy, Y., Koturbash, I., and Kovalchuk, O. (2009). Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner. Environ. Mol. Mutagen. 50, 105-113.
8. Kadhim, M. A., MacDonald, D. A., Goodhead, D. T., Lorimore, S. A., Marsden, S. J., and Wright, E. G. (1992). Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature 355, 738-740.
9. Kaup, S., Grandjean, V., Mukherjee, R., Kapoor, A., Keyes, E., Seymour, C. B., Mothersill, C. E., and Schofield, P. N. (2006). Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes. Mutat. Res. 597, 87-97.
10. Kovalchuk, O., Zemp, F. J., Filkowski, J. N., Altamirano, A. M., Dickey, J. S., Jenkins-Baker, G., Marino, S. A., Brenner, D. J., Bonner, W M., and Sedelnikova, O. A. (2010). MicroR-NAome changes in bystander three-dimensional human tissue models suggest priming of apop-totic pathways. Carcinogenesis 31, 1882-1888.
11. Kuhn, T. S. (1970). The Structure of Scientific Revolutions, 2nd Edn, Foundations of the Unity of Science. Chicago: The University of Chicago Press.
12. Lamarck, J. B. (1963). Zoological Philosophy, an Exposition with Regard to the Natural History of Animals, trans. Hugh Elliot. New York: Hafner Publ. Co.
13. Loeb, L. A. (2011). Human cancers express mutator phenotypes: origin, consequences and targeting. Nat. Rev. Cancer 11, 450-457.
14. Lorimore, S. A., Coates, P. J., and Wright, E. G. (2003). Radiation-induced genomic instability and bystander effects: inter-related non-targeted effects of exposure to ionizing radiation. Oncogene 22, 7058-7069.
15. Lyng, F. M., Maguire, P., McClean, B., Seymour, C., and Mothersill, C. (2006). The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiat. Res. 165, 400-409.
16. Lyng, F. M., Seymour, C. B., and Mothersill, C. (2000). Production of a signal by irradiated cells which leads to a response in unirradi-ated cells characteristic of initiation of apoptosis. Br. J. Cancer 83, 1223-1230.
17. Mendonca, M. S., Kurohara, W., Anto-niono, R., and Redpath, J. L. (1989). Plating efficiency as a function of time postirradiation: evidence for the delayed expression of lethal mutations. Radiat. Res. 119, 387-393.
18. Morgan, W. F. (2003a). Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159, 567-580.
19. Morgan, W. F. (2003b). Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159, 581-596.
20. Morgan, W F. (2011). Communicating non-targeted effects of ionizing radiation to achieve adaptive homeosta-sis in tissues. Curr. Mol. Pharmacol. 4, 135-140.
21. Mothersill, C., Kadhim, M. A., O'Reilly, S., Papworth, D., Marsden, S. J., Seymour, C. B., and Wright, E. G. (2000). Dose- and time-response relationships for lethal mutations and chromosomal instability induced by ionizing radiation in an immortalized human ker-atinocyte cell line. Int. J. Radiat. Biol. 76, 799-806.
22. Mothersill, C., Lyng, F., Seymour, C., Maguire, P., Lorimore, S., and Wright, E. (2005). Genetic factors influencing bystander signaling in murine bladder epithelium after low-dose irradiation in vivo. Radiat. Res. 163, 391-399.
23. Mothersill, C., and Seymour, C. (1997). Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradi-ated cells. Int. J. Radiat. Biol. 71, 421-427.
24. Mothersill, C., and Seymour, C. (2001). Radiation-induced bystander effects: past history and future directions. Radiat. Res. 155, 759-767.
25. Mothersill, C., and Seymour, C. (2006). Radiation-induced bystander and other non-targeted effects: novel intervention points in cancer therapy? Curr. Cancer Drug Targets 6, 447-454.
26. Mothersill, C., and Seymour, C. (2012). Changing paradigms in radiobiology. Mutat. Res. [Epub ahead of print].
27. Mothersill, C., Smith, R. W., Fazzari, J., McNeill, F., Prestwich, W., and Seymour, C. B. (in press). Evidence for a physical component to the radiation-induced bystander effect. Int. J. Radiat. Biol.
28. Mothersill, C., Smith, R. W., Saroya, R., Denbeigh, J., Rowe, B., Banevi-cius, L., Timmins, R., Moccia, R., and Seymour, C. B. (2010). Irradiation of rainbow trout at early life stages results in legacy effects in adults. Int. J. Radiat. Biol. 86, 817-828.
29. The effect of x-ray on the resistance to cancer in mice
30. Nagasawa, H., and Little, J. B. (1992). Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 52, 6394-6396.
31. O'Reilly, S., Mothersill, C., and Seymour, C. B. (1994). Postirradiation expression of lethal mutations in an immortalized human keratinocyte cell line. Int. J. Radiat. Biol. 66, 77-83.
32. Poon, R. C., Agnihotri, N., Seymour, C., and Mothersill, C. (2007). Bystander effects of ionizing radiation can be modulated by signaling amines. Environ. Res. 105, 200-211.
33. Prise, K. M., and O'Sullivan, J. M. (2009). Radiation-induced bystander signalling in cancer therapy. Nat. Rev. Cancer 9, 351-360.
34. Saroya, R., Smith, R., Seymour, C., and Mothersill, C. (2009). Injection of reserpine into zebrafish, prevents fish to fish communication of radiation-induced bystander signals: confirmation in vivo of a role for serotonin in the mechanism. Dose Response8, 317-330.
35. Seymour, C. B., and Mothersill, C. (1988). Clonogenicity of the progeny of surviving cells after irradiation. Int. J. Radiat. Biol. 54, 497-504.
36. Seymour, C. B., and Mothersill, C. (1997). Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment. Radiat. Oncol. Investig. 5, 106-110.
37. Seymour, C. B., Mothersill, C., and Alper, T. (1986). High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 50, 167-179.
38. Sgouros, G., Knox, S. J., Joiner, M. C., Morgan, W. F., and Kassis, A. I. (2007). MIRD continuing education: bystander and low dose-rate effects: are these relevant to radionu-clide therapy? J. Nucl. Med. 48, 1683-1691.
39. Surinov, B. P., Isaeva, V. G., and Tokarev, O. I. U. (2001). Allelopathic activity of volatile secretions in irradiated animals. Radiats. Biol. Radioecol. 41, 645-649.
40. Tamminga, J., and Kovalchuk, O. (2011). Role of DNA damage and epigenetic DNA methylation changes in radiation-induced genomic instability and bystander effects in germline in vivo. Curr. Mol. Pharmacol. 4, 115-125.
41. Vines, A. M., Lyng, E M., McClean, B., Seymour, C., and Mothersill, C. E. (2008). Bystander signal production and response are independent processes which are cell line dependent. Int. J. Radiat. Biol. 84, 83-90.