microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways

Carcinogenesis

Volumn 31, Issue 10, 2010, Pages 1882-1888

  Kovalchuk, Olga ^a   Zemp, Franz J ^a   Filkowski, Jody N ^a   Altamirano, Alvin M ^a   Dickey, Jennifer S ^b   Jenkins Baker, Gloria ^c   Marino, Stephen A ^c   Brenner, David J ^c   Bonner, William M ^b   Sedelnikova, Olga A ^b  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA METHYLTRANSFERASE 3A; MICRORNA; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR E2F; E2F1 PROTEIN, HUMAN; MIRN29 MICRORNA, HUMAN; MYELOID LEUKEMIA FACTOR 1; PROTEIN BCL 2; TRANSCRIPTION FACTOR E2F1;

APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CELL CYCLE; CELL CYCLE REGULATION; CELL PROLIFERATION; DNA METHYLATION; HUMAN; HUMAN TISSUE; IRRADIATION; MICROARRAY ANALYSIS; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SIGNAL TRANSDUCTION; UPREGULATION; CHROMOSOME MAP; ONCOGENE MYC; PHYSIOLOGY; RADIATION RESPONSE;

APOPTOSIS; BYSTANDER EFFECT; CHROMOSOME MAPPING; E2F1 TRANSCRIPTION FACTOR; GENES, MYC; HUMANS; MICRORNAS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 77957757787     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq119     Document Type: Article

References (58)

1. Maguire, P. et al. (2007) Modulation of radiation responses by pre-exposure to irradiated cell conditioned medium. Radiat. Res., 167, 485-492.
2. Sokolov, M.V. et al. (2005) Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene, 24, 7257-7265.
3. Lyng, F.M. et al. (2006) The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiat. Res., 165, 400-409.
4. Gaugler, M.H. et al. (2007) Intestinal epithelial cell dysfunction is mediated by an endothelial-specific radiation-induced bystander effect. Radiat. Res., 167, 185-193.
5. Vines, A.M. et al. (2009) Bystander effect induced changes in apoptosis related proteins and terminal differentiation in in vitro murine bladder cultures. Int. J. Radiat. Biol., 85, 48-56.
6. Belyakov, O.V. et al. (2006) Bystander-induced differentiation: a major response to targeted irradiation of a urothelial explant model. Mutat. Res., 597, 43-49.
7. Persaud, R. et al. (2005) Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Res., 65, 9876-9882.
8. Pinto, M. et al. (2006) Bystander responses in three-dimensional cultures containing radiolabelled and unlabelled human cells. Radiat. Prot Dosimetry, 122, 252-255.
9. Belyakov, O.V. et al. (2005) Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc. Natl Acad. Sci. USA, 102, 14203-14208.
10. Sedelnikova, O.A. et al. (2007) DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res., 67, 4295-4302.
11. Morgan, W.F. et al. (2007) Non-targeted bystander effects induced by ionizing radiation. Mutat. Res., 616, 159-164.
12. Morgan, W.F. (2003) Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat Res., 159, 567-580.
13. Morgan, W.F. (2003) Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation? Oncogene, 22, 7094-7099.
14. Morgan, W.F. (2003) Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res., 159, 581-596.
15. Mothersill, C. et al. (2004) Radiation-induced bystander effects-implications for cancer. Nat. Rev. Cancer, 4, 158-164.
16. Kaup, S. et al. (2006) Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes. Mutat. Res., 597, 87-97.
17. Wright, E.G. et al. (2006) Untargeted effects of ionizing radiation: implications for radiation pathology. Mutat. Res., 597, 119-132.
18. Jaenisch, R. et al. (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet., 33 (suppl.), 245-254.
19. Eulalio, A. et al. (2008) Getting to the root of miRNA-mediated gene silencing. Cell, 132, 9-14.
20. Foshay, K.M. et al. (2007) Small RNAs, big potential: the role of micro-RNAs in stem cell function. Curr. Stem Cell Res. Ther., 2, 264-271.
21. Carleton, M. et al. (2007) MicroRNAs and cell cycle regulation. Cell Cycle, 6, 2127-2132.
22. Jovanovic, M. et al. (2006) miRNAs and apoptosis: RNAs to die for. Oncogene, 25, 6176-6187.
23. Fabbri, M. et al. (2007) MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl Acad. Sci. USA, 104, 15805-15810.
24. Koturbash, I. et al. (2008) Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice. Cell Cycle, 7, 1658-1667.
25. Tamminga, J. et al. (2008) DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation. Cell Cycle, 7, 3731-3736.
26. Ilnytskyy, Y. et al. (2008) Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem. Biophys. Res. Commun., 377, 41-45.
27. Koturbash, I. et al. (2007) Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis, 28, 1831-1838.
28. Boelsma, E. et al. (2000) Characterization and comparison of reconstructed skin models: morphological and immunohistochemical evaluation. Acta Derm. Venereol., 80, 82-88.
29. Ziegler, A. et al. (2009) Aberration-corrected microscopy for structural biology applications. J. Microsc., 233, 170-177.
30. Bonner, W.M. et al. (2008) GammaH2AX and cancer. Nat. Rev. Cancer, 8, 957-967.
31. Kovalchuk, O. et al. (2008) Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol. Cancer Ther., 7, 2152-2159.
32. Bolstad, B.M. et al. (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics, 19, 185-193.
33. Eisen, M.B. et al. (1998) Cluster analysis and display of genome-wide expression patterns. Proc. Natl Acad. Sci. USA, 95, 14863-14868.
34. Rogakou, E.P. et al. (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem., 273, 5858-5868.
35. O'Donnell, K.A. et al. (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature, 435, 839-843.
36. Petrocca, F. et al. (2008) Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res., 68, 8191-8194.
37. Mendell, J.T. (2008) miRiad roles for the miR-17-92 cluster in development and disease. Cell, 133, 217-222.
38. Matsumura, I. et al. (2003) E2F1 and c-Myc in cell growth and death. Cell Cycle, 2, 333-338.
39. Volinia, S. et al. (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl Acad. Sci. USA, 103, 2257-2261.
40. Leiderman, Y.I. et al. (2007) Molecular genetics of RB1-the retinoblastoma gene. Semin. Ophthalmol., 22, 247-254.
41. Calin, G.A. et al. (2002) Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA, 99, 15524-15529.
42. Mott, J.L. et al. (2007) mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene, 26, 6133-6140.
43. Knoepfler, P.S. (2007) Myc goes global: new tricks for an old oncogene. Cancer Res., 67, 5061-5063.
44. Coller, H.A. et al. (2007) "Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron. PLoS Genet, 3, e146.
45. Nieminen, A.I. et al. (2007) c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J., 26, 1055-1067.
46. Nieminen, A.I. et al. (2007) c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc. Cell Cycle, 6, 2464-2472.
47. Bissonnette, R.P. et al. (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature, 359, 552-554.
48. Chen, T. et al. (2005) Induction of apoptosis in mouse liver by microcystin-LR: a combined transcriptomic, proteomic, and simulation strategy. Mol. Cell. Proteomics, 4, 958-974.
49. Huang, X. et al. (2003) Cell to cell contact required for bystander effect of the TNF-related apoptosis-inducing ligand (TRAIL) gene. Int. J. Oncol., 22, 1241-1245.
50. Shareef, M.M. et al. (2007) Role of tumor necrosis factor-alpha and TRAIL in high-dose radiation-induced bystander signaling in lung adenocarcinoma. Cancer Res., 67, 11811-11820.
51. Azzam, E.I. et al. (2001) Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl Acad. Sci. USA, 98, 473-478.
52. van Rooij, E. et al. (2008) Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ. Res., 103, 919-928.
53. Elmen, J. et al. (2008) LNA-mediated microRNA silencing in non-human primates. Nature, 452, 896-899.
54. Sedelnikova, O.A. et al. (2010) Role of oxidatively induced DNA lesions in human pathogenesis. Mutat. Res., 704, 152-159.
55. Simone, N.L. et al. (2009) Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One, 4, e6377.
56. Guo, C.J. et al. (2009) miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis. J. Hepatol., 50, 766-778.
57. Xia, H. et al. (2009) MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. Biochem. Biophys. Res. Commun., 380, 205-210.
58. Xia, L. et al. (2008) miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int. J. Cancer, 123, 372-379.