Intramuscular inoculation of mice with the live-attenuated recombinant rabies virus TriGAS results in a transient infection of the draining lymph nodes and a robust, long-lasting protective immune response against rabies

Journal of Virology

Volumn 87, Issue 3, 2013, Pages 1834-1841

  Schutsky, Keith ^a   Curtis, Dana ^a   Bongiorno, Emily K ^a   Barkhouse, Darryll A ^a   Kean, Rhonda B ^a   Dietzschold, Bernhard ^a   Hooper, D Craig ^a   Faber, Milosz ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INACTIVATED VACCINE; LIVE VACCINE; MESSENGER RNA; RABIES VACCINE; TRIGAS VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; BRAIN; CELL ISOLATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DENDRITIC CELL; DRUG EFFICACY; DRUG SAFETY; GENOMICS; IMMUNE RESPONSE; IMMUNITY; IMMUNOGENICITY; IMMUNOSTIMULATION; INOCULATION; LYMPH NODE; LYMPH NODE CELL; LYMPHOCYTE SUBPOPULATION; MOUSE; MUSCLE TISSUE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RABIES; SPINAL CORD; SPLEEN; VIRUS INHIBITION;

ANIMALS; B-LYMPHOCYTES; BRAIN; DENDRITIC CELLS; FEMALE; INJECTIONS, INTRAMUSCULAR; LYMPH NODES; MICE; MUSCLES; RABIES; RABIES VACCINES; RABIES VIRUS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, VIRAL; SPINAL CORD; SPLEEN; VACCINES, ATTENUATED;

EID: 84873035142     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02589-12     Document Type: Article

References (35)

1. Knobel DL, Cleaveland S, Coleman PG, Fevre EM, Meltzer MI, Miranda ME, Shaw A, Zinsstag J, Meslin FX. 2005. Re-evaluating the burden of rabies in Africa and Asia. Bull. World Health Organ. 83:360-368.
2. Hampson K, Dushoff J, Cleaveland S, Haydon DT, Kaare M, Packer C, Dobson A. 2009. Transmission dynamics and prospects for the elimination of canine rabies. PLoS Biol. 7:e53. doi:10.1371/journal.pbio.1000053.
3. WHO. 2004. WHO expert consultation on rabies 2004. WHO technical report series 931. World Health Organization, Geneva, Switzerland. http: //www.who.int/rabies/trs931_%2006_05.pdf.
4. Dietzschold B, Schnell M, Koprowski H. 2005. Pathogenesis of rabies. Curr. Top. Microbiol. Immunol. 292:45-56.
5. Faber M, Pulmanausahakul R, Nagao K, Prosniak M, Rice AB, Koprowski H, Schnell MJ, Dietzschold B. 2004. Identification of viral genomic elements responsible for rabies virus neuroinvasiveness. Proc. Natl. Acad. Sci. U. S. A. 101:16328 -16332.
6. Lafon M. 2004. Subversive neuroinvasive strategy of rabies virus. Arch. Virol. Suppl. 2004:149 -159.
7. Wiktor TJ, Doherty PC, Koprowski H. 1977. Suppression of cellmediated immunity by street rabies virus. J. Exp. Med. 145:1617-1622.
8. Faber M, Faber ML, Li J, Preuss MA, Schnell MJ, Dietzschold B. 2007. Dominance of a nonpathogenic glycoprotein gene over a pathogenic glycoprotein gene in rabies virus. J. Virol. 81:7041-7047.
9. Faber M, Faber ML, Papaneri A, Bette M, Weihe E, Dietzschold B, Schnell MJ. 2005. A single amino acid change in rabies virus glycoprotein increases virus spread and enhances virus pathogenicity. J. Virol. 79: 14141-14148.
10. Dietzschold B, Li J, Faber M, Schnell M. 2008. Concepts in the pathogenesis of rabies. Future Virol. 3:481- 490.
11. Faber M, Pulmanausahakul R, Hodawadekar SS, Spitsin S, McGettigan JP, Schnell MJ, Dietzschold B. 2002. Overexpression of the rabies virus glycoprotein results in enhancement of apoptosis and antiviral immune response. J. Virol. 76:3374 -3381.
12. Morimoto K, Hooper DC, Spitsin S, Koprowski H, Dietzschold B. 1999. Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J. Virol. 73:510 -518.
13. McGettigan JP, Pomerantz RJ, Siler CA, McKenna PM, Foley HD, Dietzschold B, Schnell MJ. 2003. Second-generation rabies virus-based vaccine vectors expressing human immunodeficiency virus type 1 Gag have greatly reduced pathogenicity but are highly immunogenic. J. Virol. 77:237-244.
14. Mebatsion T. 2001. Extensive attenuation of rabies virus by simultaneously modifying the dynein light chain binding site in the P protein and replacing Arg333 in the G protein. J. Virol. 75:11496 -11502.
15. Dietzschold ML, Faber M, Mattis JA, Pak KY, Schnell MJ, Dietzschold B. 2004. In vitro growth and stability of recombinant rabies viruses designed for vaccination of wildlife. Vaccine 23:518 -524.
16. Faber M, Dietzschold B, Li J. 2009. Immunogenicity and safety of recombinant rabies viruses used for oral vaccination of stray dogs and wildlife. Zoonoses Public Health 56:262-269.
17. Faber M, Li J, Kean RB, Hooper DC, Alugupalli KR, Dietzschold B. 2009. Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus. Proc. Natl. Acad. Sci. U. S. A. 106:11300 -11305.
18. Li J, Ertel A, Portocarrero C, Barkhouse DA, Dietzschold B, Hooper DC, Faber M. 2012. Postexposure treatment with the live-attenuated rabies virus (RV) vaccine TriGAS triggers the clearance of wild-typeRABV from the central nervous system (CNS) through the rapid induction of genes relevant to adaptive immunity in CNS tissues. J. Virol. 86:3200- 3210.
19. Jackson AC. 2011. Research advances in rabies, vol 79. Academic Press, London, United Kingdom.
20. Li J, Faber M, Dietzschold B, Hooper DC. 2011. The role of toll-like receptors in the induction of immune responses during rabies virus infection. Adv. Virus Res. 79:115-126.
21. Cox JH, Dietzschold B, Schneider LG. 1977. Rabies virus glycoprotein. II. Biological and serological characterization. Infect. Immun. 16:754 -759.
22. Celis E, Wiktor TJ, Dietzschold B, Koprowski H. 1985. Amplification of rabies virus-induced stimulation of human T-cell lines and clones by antigen- specific antibodies. J. Virol. 56:426-433.
23. Hooper DC, Morimoto K, Bette M, Weihe E, Koprowski H, Dietzschold B. 1998. Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system. J. Virol. 72:3711-3719.
24. Xiang ZQ, Spitalnik S, Tran M, Wunner WH, Cheng J, Ertl HC. 1994. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 199:132-140.
25. Li J, McGettigan JP, Faber M, Schnell MJ, Dietzschold B. 2008. Infection of monocytes or immature dendritic cells (DCs) with an attenuated rabies virus results in DC maturation and a strong activation of the NFκB signaling pathway. Vaccine 26:419-426.
26. Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G. 2006. 5'-Triphosphate RNA is the ligand for RIG-I. Science 314:994 -997.
27. Hornung V, Schlender J, Guenthner-Biller M, Rothenfusser S, Endres S, Conzelmann KK, Hartmann G. 2004. Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a singlestranded RNA virus. J. Immunol. 173:5935-5943.
28. Sato M, Maeda N, Yoshida H, Urade M, Saito S. 1977. Plaque formation of herpes virus hominis type 2 and rubella virus in variants isolated from the colonies of BHK21/WI-2 cells formed in soft agar. Arch. Virol. 53: 269-273.
29. Wiktor TJ, Macfarlan RI, Foggin CM, Koprowski H. 1984. Antigenic analysis of rabies and Mokola virus from Zimbabwe using monoclonal antibodies. Dev. Biol. Stand. 57:199 -211.
30. Phares TW, Kean RB, Mikheeva T, Hooper DC. 2006. Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system. J. Immunol. 176:7666 -7675.
31. Gray D. 2002. A role for antigen in the maintenance of immunological memory. Nat. Rev. Immunol. 2:60-65.
32. Mims CA, Nash A, Stephen J. 2000. Pathogenesis of infectious disease. Academic Press, London, United Kingdom.
33. Maruyama M, Lam KP, Rajewsky K. 2000. Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407:636-642.
34. Le Roux D, Le Bon A, Dumas A, Taleb K, Sachse M, Sikora R, Julithe M, Benmerah A, Bismuth G, Niedergang F. 2012. Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells. Blood 119:95-105.
35. Vikstrom I, Tarlinton DM. 2011. B cell memory and the role of apoptosis in its formation. Mol. Immunol. 48:1301-1306.