Droplet digital signal generation in microfluidic networks using model predictive control

Journal of Process Control

Volumn 23, Issue 2, 2013, Pages 132-139

  Maddala, Jeevan ^a   Rengaswamy, Raghunathan ^a  

^a Department of Electrical and Computer Engineering   (United States)

Author keywords

Digital signals; Discrete bubble microfluidics; MPC

Indexed keywords

CONTROL ELEMENTS; DIGITAL SIGNALS; MICROFLUIDIC NETWORKS; MPC; OBJECTIVE FUNCTIONS; TEMPORAL DYNAMICS;

DROPS; MODEL PREDICTIVE CONTROL; PREDICTIVE CONTROL SYSTEMS; SIGNAL GENERATORS;

MICROFLUIDICS;

EID: 84872976171     PISSN: 09591524     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jprocont.2012.08.014     Document Type: Conference Paper

References (20)

1. S.C. Glotzer, M.J. Solomon, and N.A. Kotov Self-assembly: from nanoscale to microscale colloids AIChE Journal 50 12 2004 2978 2985 10.1002/aic.10413 http://dx.doi.org/10.1002/aic.10413
2. D. Chen, W. Du, Y. Liu, W. Liu, A. Kuznetsov, F.E. Mendez, L.H. Philipson, and R.F. Ismagilov The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution Proceedings of the National Academy of Sciences of United States of America 105 44 2008 16843 16848 10.1073/pnas.0807916105
3. P.R. LeDuc, W.C. Messner, and J.P. Wikswo How do control-based approaches enter into biology? Annual Review of Biomedical Engineering 13 1 2011 369 396 10.1146/annurev-bioeng-071910-124651
4. G. Cristobal, J.P. Benoit, M. jaonicot, and A. Ajdari Microfluidic bypass for efficient passive regulation of droplet traffic at a junction Applied Physics Letters 89 034104 2006 1 3 10.1063/1.2221929
5. G.F. Christopher, J. Bergstein, N.B. End, M. Poon, C. Nguyen, and S.L. Anna Coalscence and splitting of confined droplets at microfluidic junctions Lab on Chip 9 2009 1102 1109 10.1039/b813062k
6. B.J. Jin, Y.W. Kim, Y. Lee, and J.Y. Yoo Droplet merging in a straight microchannel using droplet size or viscosity difference Journal of Micromechanics and Microengineering 20 035003 2010 1 3 10.1088/0960-1317/20/3/ 035003
7. X. Niu, S. Gulati, J.B. Edel, and A.J. deMello Pillar-induced droplet merging in microfluidic circuits Lab on Chip 8 2008 1837 1841 10.1039/b813325e
8. H. Boukellal, S. Selimovic, Y. Jia, G. Cristobal, and S. Fraden Simple, robust storage of drops and fluids in a microfluidic device Lab on Chip 9 2008 331 338 10.1039/b808579j
9. T.C. Chao, and A. Ros Microfluidic single-cell analysis of intracellular compounds Journal of the Royal Society Interface 5 Suppl 2 2008 S139 S150 10.1098/rsif.2008.0233.focus
10. E. Brouzes, M. Medkova, N. Savenelli, D. Marran, M. twardowski, J.B. Hutchison, J.M. Rothberg, D.R. Link, N. Perrimon, and M.L. Samuels Droplet microfluidic technology for single-cell high throughput screening Proceedings of the National Academy of Sciences of United States of America 106 34 2009 14195 14200 10.1073/pnas.0903542106
11. D. Dendukuri, and P.S. Doyle The synthesis and assembly of polymeric microparticles using microfluidics Advanced Materials 21 41 2009 4071 4086
12. O. Cybulski, and P. Garstecki Dynamic memory in a microfluidic system of droplets traveling through a simple network of microchannels Lab on Chip 10 2009 484 493 10.1039/b912988j
13. B.J. Smith, P. Donald, and I. Gaver Agent-based simulations of complex droplet pattern formation in a two-branch microfluidic network Lab on Chip 10 2010 303 312 10.1039/b916380h
14. A.R. Abate, J.J. Agresti, and D.A. Weitz Microfluidic sorting with high-speed single layer membrane valves Applied Physics Letters 96 203509 2010 1 3 10.1063/1.3431281
15. J. Maddala, B. Srinivasan, S.S. Bithi, S.A. Vanapalli, and R. Rengaswamy Design of a model-based feedback controller for active sorting and synchronization of droplets in a microfluidic loop AIChE Journal 58 7 2012 2120 2130 10.1002/aic.12740 http://dx.doi.org/10.1002/aic.12740
16. J. Maddala, S.A. Vanapalli, and R. Rengaswamy Sort-synchronization control in microfluidic loop devices with experimental uncertainties using a model predictive control (MPC) framework International Federation of Automatic Control (IFAC) 2011 4886 4891
17. M. Schindler, and A. Ajdari Droplet traffic microfluidic networks: a simple model for understanding and designing Physical Review Letters 100 044501 2008 1 4 10.1103/PhysRevLett.100.044501
18. P. Garstecki, M.J. Fuerstman, H.A. Stone, and G.M. Whitesides Formation of droplets and bubbles in a microfluidic t-junction-scaling and mechanism of break-up Lab on Chip 6 2006 437 446 10.1039/B510841A http://dx.doi.org/10.1039/ B510841A
19. A.R. Abate, and D.A. Weitz Single-layer membrane valves for elastomeric microfluidic devices Applied Physics Letters 92 243509 2008 1 3 10.1063/1.2945797
20. O. Lipan, and W.H. Wong The use of oscillatory signals in the study of genetic networks Proceedings of the National Academy of Sciences of United States of America 102 20 2005 7063 7068 10.1073/pnas.0403790102