Severe hyperglycemia immediately after allogeneic hematopoietic stem-cell transplantation is predictive of acute graft-versus-host disease

Inflammation

Volumn 36, Issue 1, 2013, Pages 177-185

  Gebremedhin, Efrem ^a,b   Behrendt, Carolyn E ^a   Nakamura, Ryotaro ^a   Parker, Pablo ^a   Salehian, Behrouz ^a,b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

acute graft versus host disease; biomarker; glucose metabolism disorders; hematopoietic stem cell transplantation; leukemia

Indexed keywords

CYCLOSPORIN; GLUCOSE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BLOOD DONOR; BODY MASS; CYTOKINE STORM; DISEASE ASSOCIATION; DISEASE SEVERITY; ENGRAFTMENT; FEMALE; FEVER; GLUCOSE BLOOD LEVEL; GRAFT RECIPIENT; HLA MATCHING; HUMAN; HYPERGLYCEMIA; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MYELODYSPLASTIC SYNDROME; OBESITY; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION;

ADOLESCENT; ADULT; AGED; BLOOD GLUCOSE; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; HYPERGLYCEMIA; INFLAMMATION; LEUKEMIA; MALE; MIDDLE AGED; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 84872974947     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-012-9533-7     Document Type: Article

References (34)

1. Ferrara, J.L., J.E. Levine, P. Reddy, et al. 2009. Graft-versus-host disease. Lancet 373: 1550-1561.
2. Hahn, T., P.L. McCarthy Jr., M.J. Zhang, et al. 2008. Risk factors for acute graft-versus-host disease after human leukocyte antigen-identical sibling transplants for adults with leukemia. Journal of Clinical Oncology 26: 5728-5734.
3. Au, W.Y., R.W.M. Wong, B.C.Y. Wong, et al. 2004. Reduced incidence of acute graft versus host disease (GVHD) of the gut in Chinese carriers of helicobacter pylori during allogeneic bone marrow transplantation. Annals of Hematology 83: 34-37. (Pubitemid 38088234)
4. Goldberg, J., D.A. Jacobsohn, M.L. Zahurak, et al. 2005. Gastrointestinal toxicity from the preparative regimen is associated with an increased risk of graft-versus-host disease. Biology of Blood and Marrow Transplantation 11: 101-107. (Pubitemid 40186206)
5. Liu, D., C. Yan, L. Xu, et al. 2010. Diarrhea during the conditioning regimen is correlated with the occurrence of severe acute graft-versus-host disease through systemic release of inflammatory cytokines. Biology of Blood and Marrow Transplantation 16: 1567-1575.
6. Hill, G.R., J.M. Crawford, K.R. Cooke, et al. 1997. Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines. Blood 90: 3204-3213. (Pubitemid 27444217)
7. Conway, S.E., and R. Abdi. 2009. Immunoregulatory gene polymorphisms and graft-versus-host disease. Expert Review of Clinical Immunology 5: 523-534.
8. Paczesny, S., O.I. Krijanovski, T.M. Braun, et al. 2009. A biomarker panel for acute graft-versus-host disease. Blood 113: 273-278.
9. Miyamoto, T., K. Akashi, S. Hayashi, et al. 1996. Serum concentration of the soluble interleukin-2-receptor for monitoring of acute graft-versus-host disease. Bone Marrow Transplantation 17: 185-190. (Pubitemid 26057305)
10. Kayaba, H., M. Hirokawa, A. Watanabe, et al. 2000. Serum markers of graft-versus-host disease after bone marrow transplantation. Allergy and Clinical Immunology 106: 40-44.
11. Remberger, M., O. Ringden, and M. Markling. 1995. TNF-α levels are increased during bone marrow transplantation conditioning in patients who develop acute GVHD. Bone Marrow Transplantation 15: 99-104.
12. Choi, S.W., C.L. Kitko, T. Braun, et al. 2008. Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival. Blood 112: 1539-1542.
13. Umpierrez, G.E., S.D. Isaacs, N. Bazargan, et al. 2002. Hyperglycemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes. Journal of Clinical Endocrinology and Metabolism 87: 978-982. (Pubitemid 36121050)
14. McCowen, K.C., A. Malhotra, and B.R. Bistrian. 2001. Stress-induced hyperglycemia. Critical Care Clinics 17: 107-124. (Pubitemid 32163181)
15. Boura-Halfon, S., and Y. Zick. 2009. Phosphorylation of IRS proteins, insulin action, and insulin resistance. American Journal of Physiology, Endocrinology and Metabolism 296: E581-E591.
16. Esposito, K., F. Nappo, R. Marfella, et al. 2002. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: Role of oxidative stress. Circulation 106: 2067-2072. (Pubitemid 35192812)
17. Fuji, S., S.W. Kim, S.I. Mori, et al. 2007. Hyperglycemia during the neutropenic period is associated with a poor outcome in patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation. Transplantation 84: 814-820. (Pubitemid 351338940)
18. Saliba, R.M., M.D. Lima, S. Giralt, et al. 2007. Hyperacute GVHD: Risk factors, outcomes and clinical implications. Blood 109: 2751-2758. (Pubitemid 46482067)
19. Przepiorka, D., D. Weisdorf, P. Martin, et al. 1995. 1994 consensus conference on acute GVHD grading. Bone Marrow Transplantation 15: 825-828.
20. Cancer Therapy Evaluation Program, Common Terminology Criteria for Adverse Events, Version 3.0, DCTD, NCI, NIH, DHHS. Available at http://ctep.cancer.gov/protocolDevelopment/electronic-Applications/docs/ctcaev3. pdf. Accessed 11 January 2012.
21. Harris, J.A., and F.G. Benedict. 1918. A biometric study of human basal metabolism. Proceedings of the National Academy of Sciences of the United States of America 4: 370-373.
22. Gray, R.J. 1988. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Annals of Statistics 16: 1141-1154.
23. Klein, J.P., and P.K. Andersen. 2005. Regression modeling of competing risks data based on pseudovalues of the cumulative incidence function. Biometrics 61: 223-229. (Pubitemid 40380983)
24. Klein, J.P., M. Gerster, P.K. Andersen, et al. 2008. SAS and R functions to compute pseudo-values for censored data regression. Computer Methods and Programs in Biomedicine 89: 289-300.
25. Chawla, A., K.D. Nguyen, and Y.P. Goh. 2011. Macrophage-mediated inflammation in metabolic disease. Nature Reviews Immunology 11: 738-749.
26. Fuji, S., S.W. Kim, K. Yoshimura, et al. 2009. Possible association between obesity and posttransplantation complications including infectious diseases and acute graft-versus-host disease. Biology of Blood and Marrow Transplantation 15: 73-82.
27. Fuji, S., S.W. Kim, S.I. Mori, et al. 2009. Intensive glucose control after allogeneic hematopoietic stem cell transplantation: A retrospective matched-cohort study. Bone Marrow Transplantation 44: 105-111.
28. Navarro, W.H., M.A. Agovi, B.R. Logan, et al. 2010. Obesity does not preclude safe and effective myeloablative hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) in adults. Biology of Blood and Marrow Transplantation 16: 1442-1450.
29. Woo, M., D. Przepiorka, C. Ippoliti, et al. 1997. Toxicities of tacrolimus and cyclosporin A after allogeneic blood stem cell transplantation. Bone Marrow Transplantation 20: 1095-1098. (Pubitemid 28043423)
30. Øzbay, L.A., K. Smidt, D.M. Mortensen, et al. 2011. Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells. British Journal of Pharmacology 162: 136-146.
31. Pandit, M.K., J. Burke, A.B. Gustafson, et al. 1993. Drug-induced disorders of glucose tolerance. Annals of Internal Medicine 118: 529-539. (Pubitemid 23085796)
32. Tsubouchi, S., H. Suzuki, H. Ariyoshi, et al. 1981. Radiation-induced acute necrosis of the pancreatic islet and the diabetic syndrome in the golden hamster (Mesocricetus auratus). International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 40: 95-106. (Pubitemid 11064726)
33. Feng, J.P., X.L. Yuan, M. Li, et al. 2012. Secondary diabetes associated with 5-Fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: Results from a single centre cohort study. Colorectal Disease (in press)
34. Sheean, P., and C. Braunschwieg. 2006. The incidence and impact of dextrose dose on hyperglycemia from parenteral nutrition (PN) exposure in hematopoietic stem cell transplant (HSCT) recipients. JPEN Journal of Parenteral & Enteral Nutrition 30: 345-350.