Effect of the semen extract of thuja orientalis on inflammatory responses in transient focal cerebral ischemia rat model and LPS-stimulated BV-2 microglia

American Journal of Chinese Medicine

Volumn 41, Issue 1, 2013, Pages 99-117

  Jung, Hyo Won ^a   Kang, Seok Yong ^b   Park, Ki Ho ^b   Oh, Tae Woo ^b   Jung, Jin Ki ^b   Kim, Song Hee ^a   Choi, Dong Jun ^c   Park, Yong Ki ^a,b  

^a Dongguk University   (South Korea)

^b Dongguk University   (South Korea)

^c Dongguk University Hospital   (South Korea)

Author keywords

Inflammation; Microglia; NF B Pathway; Semen; Thuja orientalis; Transient Focal Cerebral Ischemia

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; THUJA ORIENTALIS SEMEN EXTRACT; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL VIABILITY; COMMON CAROTID ARTERY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; EXTERNAL CAROTID ARTERY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THUJA; THUJA ORIENTALIS;

ANIMALS; CELLS, CULTURED; DINOPROSTONE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; ISCHEMIC ATTACK, TRANSIENT; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MALE; MICE; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; THUJA; TRANSCRIPTION FACTOR RELA;

EID: 84872958956     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500080     Document Type: Article

References (36)

1. Basu, A., J.K. Kradyand and S.W. Levision. Interleukin-1: A master regulator of neuroinflammation J. Neurosci. Res. 78: 151-156, 2004
2. Block, M.L., L. Zecca and J.S. Hong. Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8: 57-69, 2007
3. Boje, K.M. and P.K. Arora. Microglia-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 853: 236-244, 1992
4. Chae, H.S. and Y.W. Chin. Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. Immunopharmacol. Immunotoxicol. 34: 250-255, 2012
5. Chen, Y.F. Traditional Chinese herbal medicine and cerebral ischemia. Front Biosci. 4: 809-817, 2012
6. Cunningham, C., D.C. Wilcockson, S. Campion, K. Lunnon and V.H. Perry. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 25: 9275-9284, 2005
7. Dinarello, C.A. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int. Rev Immunol. 16: 457-499, 1998
8. Fernandes, A. and D. Brites. Contribution of inflammatory processes to nerve toxicity by bilirubin and efficacy of potential therapeutic agents. Curr. Pharm. Des. 15: 2915-2926, 2009
9. Gao, H.M., J.S. Hong, W. Zhang and B. Liu. Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: Relevance to the etiology of Parkinson's disease J. Neurosci. 23: 1228-1236, 2003
10. Garden, G.A. and T. Möller. Microglia biology in health and disease. J. Neuroimmune Pharmacol. 1: 127-137, 2006
11. Guleria, S., A. Kumar and A.K. Tiku. Chemical composition and fungitoxic activity of essential oil of Thuja orientalis L. grown in the north-western Himalaya. Z. Naturforsch C. 63: 211-214, 2008
12. Ha, J.A. and L.J. Lim. Antitumor and immune modulatory effects of Bojungtang in ICR mice. Kor. J. Orient. Pathol. 12: 90-98, 1998
13. Hanisch, U.K. Microglia as a source and target of cytokines. Glia 40: 140-155, 2002
14. Hoozemans, J.J., R. Veerhuis, A.J. Rosemuller, and P. Eikelenboom. Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease. Curr. Drug Targets 4: 461-468, 2003
15. Hüll, M., K. Lieb and B.L. Fiebich. Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs. Curr. Med. Chem. 9: 83-88, 2002
16. Jordán, J., T. Segura, D. Brea, M.F. Galindo and J. Castillo. Inflammation as therapeutic objective in stroke. Curr. Pharm. Des. 14: 3549-3564, 2008
17. Ju, M.S., P. Lee, H.G. Kim, K.Y. Lee, J. Hur, S.H. Cho, S.H. Sung and M.S. Oh. Protective effects of standardized Thuja orientalis leaves against 6-hydroxydopamine-induced neurotoxicity in SHSY5Y cells. Toxicol. In Vitro 24: 759-765, 2010
18. Jung, S.H., B.J. Kim, E.H. Lee and N.N. Osborne. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem. Int. 57: 713-721, 2010
19. Kaminska, B., A. Gozdz, M. Zawadzka, A. Ellert-Miklaszewska and M. Lipko. MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target. Anat. Rec (Hoboken) 292: 1902-1913, 2009
20. Kim, H.G. and M.S. Oh. Herbal medicines for the prevention and treatment of Alzheimer's disease Curr. Pharm. Dis. 18: 57-75, 2012
21. Kim, J.Y., H.J. Kim, S.M. Kim, K.R. Park, H.J. Jang, E.H. Lee, S.H. Jung and K.S. Ahn. Methylene chloride fraction of the leaves of Thuja orientalis inhibits in vitro inflammatory biomarkers by blocking NF-B and p38 MAPK signaling and protects mice from lethal endotoxemia J. Ethnopharmacol. 133: 687-695, 2011
22. Kim, Y.S. and T.H. Joh. Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease. Exp. Mol. Med. 38: 333-347, 2005
23. Lee, Y.J., S.M. Hwang, J.J. Yoon, S.M. Lee, E.H. Kyung, J.S. Kim, D.G. Kang and H.S. Lee Inhibitory effect of Thuja orientalis on TNF-induced vascular inflammation. Phytother. Res 1489-1495, 2010
24. Lleoa, A., E. Galeab and M. Sastrec. Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases. Cell Mol. Life Sci. 64: 1403-1418, 2007
25. McGeer, E.G. and P.L. McGeer. The role of anti-inflammatory agents in Parkinson's disease. CNS Drugs 21: 789-797, 2007
26. Mingheth, L. Cycooxygenase-2 (COX-2) in inflammatory and degenerative brain disease. J. Neuropath Exp. Neur. 63: 901-910, 2004
27. Naser, B., C. Bodinet, M. Tegtmeier and U. Lindequist. Thuja occidentalis (Arbor vitae): A review of its pharmaceutical, pharmacological and clinical properties. Evid. Based Complement. Alternat Med. 2: 69-78, 2005
28. Ojeswi, B.K., M. Khoobchandani, D.K. Hazra and M.M. Srivastava. Protective effect of Thuja occidentalis against DMBA-induced breast cancer with reference to oxidative stress. Hum Exp. Toxicol. 29: 369-375, 2010
29. Rock, R.B. and P.K. Peterson. Microglia as a pharmacological target in infectious and inflammatory diseases of the brain. J. Neuroimmune Pharmacol. 1: 117-126, 2006
30. Rothwell, N.J. and G.N. Luheshi. Interleukin 1 in the brains: Biology, pathology and therapeutic target. Trends Neurosci. 23: 618-625, 2000
31. Samad, T.A., K.A. Moore, A. Sapirstein, S. Billet, A. Allchorne, S. Poole, J.V. Bonventre and C.J. Woolf. Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410: 471-475, 2001
32. Scali, C., M.G. Giovannini, C. Prosperi, A. Bellucci, G. Pepeuand and F. Casamenti. The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo. Neuroscience 117: 909-919, 2003
33. Sunila, E.S. and G. Kuttan. A preliminary study on antimetastatic activity of Thuja occidentalis L. in mice model. Immunopharmacol. Immunotoxicol. 28: 269-280, 2006
34. Svensson, C., S.Z. Fernaeus, K. Part, K. Reis and T. Land. LPS-induced iNOS expression in Bv-2 cells is suppressed by an oxidative mechanism acting on the JNK pathway-a potential role for neuroprotection. Brain Res. 1322: 1-7, 2010
35. Tzeng, S.F., H.Y. Hsiao and O.T. Mak. Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr. Drug Targets Inflamm. Allergy 4: 335-340, 2005
36. Xu, G.H., I.J. Ryoo, Y.H. Kim, S.J. Choo and I.D. Yoo. Free radical scavenging and antielastase activities of flavonoids from the fruits of Thuja orientalis. Arch. Pharm. Res. 32: 275-282, 2009