Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage

Journal of Pathology

Volumn 229, Issue 3, 2013, Pages 400-409

  Anglesio, M S ^a   Wang, Y ^a   Yang, W ^b   Senz, J ^a   Wan, A ^b   Heravi Moussavi, A ^a   Salamanca, C ^a   Maines Bandiera, S ^a   Huntsman, D G ^a,b   Morin, G B ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

5p strand loss; cancer; DICER1; miRNA processing; somatic hotspot mutations

Indexed keywords

DICER; DICER1; MESSENGER RNA; MESSENGER RNA PRECURSOR; MESSENGER RNA PRECURSOR HAIRPIN; RIBONUCLEASE III; RIBONUCLEASE IIIB; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALLELE; ANIMAL CELL; ARTICLE; BINDING SITE; CARCINOGENESIS; CONTROLLED STUDY; DICER1 GENE; EMBRYONIC STEM CELL; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETIC ENGINEERING; MESSENGER RNA SYNTHESIS; MICRORNA PROCESSING; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA 3P STRAND; RNA 5P STRAND; RNA CLEAVAGE; RNA PROCESSING; RNA STRUCTURE; SOMATIC HOTSPOT MUTATION; SOMATIC MUTATION; WILD TYPE;

ANIMALS; DEAD-BOX RNA HELICASES; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICRORNAS; MUTATION; OVARIAN NEOPLASMS; RIBONUCLEASE III; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 84872958116     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4135     Document Type: Article

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