메뉴 건너뛰기




Volumn 6, Issue , 2013, Pages 49-56

Antihyperglycemic, antihyperlipidemic, anti-inflammatory and adenosine deaminase-lowering effects of garlic in patients with type 2 diabetes mellitus with obesity

Author keywords

Allium sativum; C reactive protein; Metformin

Indexed keywords

ADENOSINE DEAMINASE; C REACTIVE PROTEIN; GLUCOSE; HEMOGLOBIN A1C; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LASUNA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84872925873     PISSN: 11787007     EISSN: None     Source Type: Journal    
DOI: 10.2147/dmso.s38888     Document Type: Article
Times cited : (96)

References (45)
  • 2
    • 0038483271 scopus 로고    scopus 로고
    • Burden of type 2 diabetes and its complications - the Indian scenario
    • Ramchandran A, Snehalatha C, Vijay V. Burden of type 2 diabetes and its complications - the Indian scenario. Current Science. 2002;83: 1471-1476.
    • (2002) Current Science , vol.83 , pp. 1471-1476
    • Ramchandran, A.1    Snehalatha, C.2    Vijay, V.3
  • 5
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
    • Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258): 405-412.
    • (2000) BMJ , vol.321 , Issue.7258 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3
  • 6
    • 0036224765 scopus 로고    scopus 로고
    • Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: Progressive, interrelated, and independently associated with risk of death
    • Stehouwer CD, Gall MA, Twisk JW, Knudsen E, Emeis JJ, Parving HH. Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death. Diabetes. 2002;51(4):1157-1165.
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 1157-1165
    • Stehouwer, C.D.1    Gall, M.A.2    Twisk, J.W.3    Knudsen, E.4    Emeis, J.J.5    Parving, H.H.6
  • 7
    • 69549105884 scopus 로고    scopus 로고
    • Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people
    • Lapice E, Maione S, Patti L, et al. Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people. Diabetes Care. 2009;32(9):1734-1736.
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1734-1736
    • Lapice, E.1    Maione, S.2    Patti, L.3
  • 8
    • 0033545342 scopus 로고    scopus 로고
    • Acute-phase proteins and other systemic responses to inflammation
    • Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340(6):448-454.
    • (1999) N Engl J Med , vol.340 , Issue.6 , pp. 448-454
    • Gabay, C.1    Kushner, I.2
  • 10
    • 0038691972 scopus 로고    scopus 로고
    • Low-grade systemic inflammation and the development of type 2 diabetes: The atherosclerosis risk in communities study
    • Duncan BB, Schmidt M, Pankow JS, et al. Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes. 2003;52(7):1799-1805.
    • (2003) Diabetes , vol.52 , Issue.7 , pp. 1799-1805
    • Duncan, B.B.1    Schmidt, M.2    Pankow, J.S.3
  • 13
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • De Fronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med. 1999;131(4):281-303.
    • (1999) Ann Intern Med , vol.131 , Issue.4 , pp. 281-303
    • de Fronzo, R.A.1
  • 14
    • 67749111421 scopus 로고    scopus 로고
    • Short-term treatment with metformin improves the cardiovascular risk profile in first-degree relatives of subjects with type 2 diabetes mellitus who have a metabolic syndrome and normal glucose tolerance without changes in C-reactive protein or fibrinogen
    • Lima LM, Wiernsperger N, Kraemer-Aguiar LG, Bouskela E. Short-term treatment with metformin improves the cardiovascular risk profile in first-degree relatives of subjects with type 2 diabetes mellitus who have a metabolic syndrome and normal glucose tolerance without changes in C-reactive protein or fibrinogen. Clinics (Sao Paulo). 2009;64(5):415-420.
    • (2009) Clinics (Sao Paulo) , vol.64 , Issue.5 , pp. 415-420
    • Lima, L.M.1    Wiernsperger, N.2    Kraemer-Aguiar, L.G.3    Bouskela, E.4
  • 15
    • 78651338445 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2011
    • American Diabetes Association
    • American Diabetes Association. Standards of medical care in diabetes - 2011. Diabetes Care. 2011;34 Suppl 1:S11-S61.
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 1
  • 16
    • 4043162976 scopus 로고    scopus 로고
    • The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: A placebo-controlled, randomized clinical trial
    • Caballero AE, Delgado A, Aguilar-Salinas CA, et al. The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: a placebo-controlled, randomized clinical trial. J Clin Endocrinol Metab. 2004;89(8):3943-3948.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.8 , pp. 3943-3948
    • Caballero, A.E.1    Delgado, A.2    Aguilar-Salinas, C.A.3
  • 17
    • 17844366621 scopus 로고    scopus 로고
    • Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance
    • Diabetes Prevention Program Research Group
    • Haffner S, Temprosa M, Crandall J, et al; Diabetes Prevention Program Research Group. Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance. Diabetes. 2005;54(5):1566-1572.
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1566-1572
    • Haffner, S.1    Temprosa, M.2    Crandall, J.3
  • 18
    • 0019130699 scopus 로고
    • WHO Expert Committee on Diabetes Mellitus: Second report
    • [No authors listed]
    • [No authors listed]. WHO Expert Committee on Diabetes Mellitus: second report. World Health OrganTech Rep Ser. 1980;646:1-80.
    • (1980) World Health OrganTech Rep Ser , vol.646 , pp. 1-80
  • 19
    • 0030029823 scopus 로고    scopus 로고
    • Therapeutic actions of garlic constituents
    • Agarwal KC. Therapeutic actions of garlic constituents. Med Res Rev. 1996;16(1):111-124.
    • (1996) Med Res Rev , vol.16 , Issue.1 , pp. 111-124
    • Agarwal, K.C.1
  • 20
    • 0028328773 scopus 로고
    • Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis
    • Yeh YY, Yeh SM. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids. 1994;29(3):189-193.
    • (1994) Lipids , vol.29 , Issue.3 , pp. 189-193
    • Yeh, Y.Y.1    Yeh, S.M.2
  • 21
    • 0029036844 scopus 로고
    • Inhibition of adenosine deaminase activity of aortic endothelial cells by extracts of garlic (Allium sativum L.)
    • Melzig MF, Krause E, Franke S. Inhibition of adenosine deaminase activity of aortic endothelial cells by extracts of garlic (Allium sativum L.). Pharmazie. 1995;50(5):359-361.
    • (1995) Pharmazie , vol.50 , Issue.5 , pp. 359-361
    • Melzig, M.F.1    Krause, E.2    Franke, S.3
  • 22
    • 84864720069 scopus 로고    scopus 로고
    • Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial
    • Zeb I, Ahmadi N, Nasir K, et al. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. J Cardiovasc Dis Res. 2012;3(3):185-190.
    • (2012) J Cardiovasc Dis Res , vol.3 , Issue.3 , pp. 185-190
    • Zeb, I.1    Ahmadi, N.2    Nasir, K.3
  • 23
    • 0035126519 scopus 로고    scopus 로고
    • Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation
    • Ide N, Lau BH. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation. J Nutr. 2001;131(Suppl 3):S1020-S1026.
    • (2001) J Nutr , vol.131 , Issue.SUPPL. 3
    • Ide, N.1    Lau, B.H.2
  • 25
    • 84872894448 scopus 로고    scopus 로고
    • The Himalaya Drug Company, Available from, Accessed January 5, 2013
    • Lasuna (capsule) [product information]. The Himalaya Drug Company; 2002. Available from: http://www.himalayahealthcare.com/products/lasuna.htm#d. Accessed January 5, 2013.
    • (2002) Lasuna (capsule) [product Information]
  • 26
    • 0014478342 scopus 로고
    • Determination of blood glucose using an oxidase peroxidase system with a non-carcinogenic chromogen
    • Trinder P. Determination of blood glucose using an oxidase peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 1969;22(2):158-161.
    • (1969) J Clin Pathol , vol.22 , Issue.2 , pp. 158-161
    • Trinder, P.1
  • 27
  • 28
    • 0003072603 scopus 로고    scopus 로고
    • Triglycerides estimation by GPO-PAP method
    • Trinder P. Triglycerides estimation by GPO-PAP method. Ann Clin Biochem. 1996;6:24-27.
    • (1996) Ann Clin Biochem , vol.6 , pp. 24-27
    • Trinder, P.1
  • 29
    • 0014876627 scopus 로고
    • Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
    • Burstein M, Scholnick HR, Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res. 1970;11(6):583-595.
    • (1970) J Lipid Res , vol.11 , Issue.6 , pp. 583-595
    • Burstein, M.1    Scholnick, H.R.2    Morfin, R.3
  • 30
    • 17044377421 scopus 로고    scopus 로고
    • Evaluation of methods for the measurement of low-density lipoprotein cholesterol
    • Bairaktari ET, Seferiadis KI, Elisaf MS. Evaluation of methods for the measurement of low-density lipoprotein cholesterol. J Cardiovasc Pharmacol Therapeut. 2005;10(1):45-54.
    • (2005) J Cardiovasc Pharmacol Therapeut , vol.10 , Issue.1 , pp. 45-54
    • Bairaktari, E.T.1    Seferiadis, K.I.2    Elisaf, M.S.3
  • 31
    • 0029866045 scopus 로고    scopus 로고
    • C reactive protein and its relation to cardiovascular risk factors: A population based cross sectional study
    • Mendall MA, Patel P, Ballam L, Strachan D, Northfield TC. C reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. BMJ. 1996;312(7038):1061-1065.
    • (1996) BMJ , vol.312 , Issue.7038 , pp. 1061-1065
    • Mendall, M.A.1    Patel, P.2    Ballam, L.3    Strachan, D.4    Northfield, T.C.5
  • 32
    • 0000900192 scopus 로고
    • Adenosine deaminase
    • Bergmeyer HU, editor, 2nd ed. New York: Academic Press Inc
    • Giusti G, Galanti R. Adenosine deaminase. In: Bergmeyer HU, editor. Methods of Enzymatic Analysis, 2nd ed. New York: Academic Press Inc; 1974;2:1092-1099.
    • (1974) Methods of Enzymatic Analysis , vol.2 , pp. 1092-1099
    • Giusti, G.1    Galanti, R.2
  • 33
    • 18244404332 scopus 로고    scopus 로고
    • Approved IFCC reference method for the measurement of HbA1c in human blood
    • International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
    • Jeppsson J, Kobold U, Barr J, et al; International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). Approved IFCC reference method for the measurement of HbA1c in human blood. Clin Chem Lab Med. 2002;40(1):78-89.
    • (2002) Clin Chem Lab Med , vol.40 , Issue.1 , pp. 78-89
    • Jeppsson, J.1    Kobold, U.2    Barr, J.3
  • 34
    • 0003615768 scopus 로고    scopus 로고
    • NIH/NHLBI (National Institutes of Health, National Heart, Lung, and Blood Insitute), Bethesda: National Institutes of Health, Available from, Accessed December 14, 2012
    • NIH/NHLBI (National Institutes of Health, National Heart, Lung, and Blood Insitute). Clinical Guidelines on the Identification, Evaluation and Treatment of Overweight and Obesity in Adults. Bethesda: National Institutes of Health; 1998. Available from: http://www.nhlbi.nih.gov/guidelines/obesity/ob_gdlns.htm. Accessed December 14, 2012.
    • (1998) Clinical Guidelines On the Identification, Evaluation and Treatment of Overweight and Obesity In Adults
  • 35
    • 84864923640 scopus 로고    scopus 로고
    • Post-prandial glucose and diabetic complications: Systematic review of observational studies
    • Mannucci E, Monami M, Lamanna C, Adalsteinsson JE. Post-prandial glucose and diabetic complications: systematic review of observational studies. Acta Diabetol. 2012;49(4):307-314.
    • (2012) Acta Diabetol , vol.49 , Issue.4 , pp. 307-314
    • Mannucci, E.1    Monami, M.2    Lamanna, C.3    Adalsteinsson, J.E.4
  • 36
    • 0029133235 scopus 로고
    • Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
    • Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med. 1995;333(9):550-554.
    • (1995) N Engl J Med , vol.333 , Issue.9 , pp. 550-554
    • Stumvoll, M.1    Nurjhan, N.2    Perriello, G.3    Dailey, G.4    Gerich, J.E.5
  • 37
    • 0029099086 scopus 로고
    • Efficacy of metformin in patients with non-insulin dependent diabetes mellitus. The Multicenter Study Group
    • DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin dependent diabetes mellitus. The Multicenter Study Group. N Eng J Med. 1995;333(9):541-549.
    • (1995) N Eng J Med , vol.333 , Issue.9 , pp. 541-549
    • Defronzo, R.A.1    Goodman, A.M.2
  • 38
    • 79961040261 scopus 로고    scopus 로고
    • Effects of garlic on blood glucose levels and HbA1c in patients with type 2 diabetes mellitus
    • Ashraf R, Alam Khan R, Ashraf I. Effects of garlic on blood glucose levels and HbA1c in patients with type 2 diabetes mellitus. J Med Plants Res. 2011;5(13):2922-2928.
    • (2011) J Med Plants Res , vol.5 , Issue.13 , pp. 2922-2928
    • Ashraf, R.1    Alam, K.R.2    Ashraf, I.3
  • 39
    • 39049143752 scopus 로고    scopus 로고
    • Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: The results of double-blinded placebo-controlled study
    • Sobenin IA, Nedosugova LV, Filatova LV, Balabolkin MI, Gorchakova TV, Orekhov AN. Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study. Acta Diabetol. 2008;45(1):1-6.
    • (2008) Acta Diabetol , vol.45 , Issue.1 , pp. 1-6
    • Sobenin, I.A.1    Nedosugova, L.V.2    Filatova, L.V.3    Balabolkin, M.I.4    Gorchakova, T.V.5    Orekhov, A.N.6
  • 40
    • 0031767174 scopus 로고    scopus 로고
    • The effects of metformin on glycemic control and serum lipids in insulin-treated NIDDM patients with suboptimal metabolic control
    • Robinson AC, Burke J, Robinson S, Johnston GD, Elkeles RS. The effects of metformin on glycemic control and serum lipids in insulin-treated NIDDM patients with suboptimal metabolic control. Diabetes Care. 1998;2(5):701-705.
    • (1998) Diabetes Care , vol.2 , Issue.5 , pp. 701-705
    • Robinson, A.C.1    Burke, J.2    Robinson, S.3    Johnston, G.D.4    Elkeles, R.S.5
  • 41
    • 3042541843 scopus 로고    scopus 로고
    • The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: A systematic review
    • Wulffelé MG, Kooy A, de Zeeuw D, Stehouwer CD, Gansevoort RT. The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review. J Int Med. 2004;256(1):1-14.
    • (2004) J Int Med , vol.256 , Issue.1 , pp. 1-14
    • Wulffelé, M.G.1    Kooy, A.2    de Zeeuw, D.3    Stehouwer, C.D.4    Gansevoort, R.T.5
  • 42
    • 0025057564 scopus 로고
    • Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients
    • Wu MS, Johnston P, Sheu WH, et al. Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients. Diabetes Care. 1990;13(1):1-8.
    • (1990) Diabetes Care , vol.13 , Issue.1 , pp. 1-8
    • Wu, M.S.1    Johnston, P.2    Sheu, W.H.3
  • 43
    • 0015475661 scopus 로고
    • Atherosclerosis in diabetes mellitus. Correlations with serum lipid levels, adiposity, and serum insulin level
    • Santen RJ, Willin PW 3rd, Fajans SS. Atherosclerosis in diabetes mellitus. Correlations with serum lipid levels, adiposity, and serum insulin level. Arch Intern Med. 1972;130(6):833-843.
    • (1972) Arch Intern Med , vol.130 , Issue.6 , pp. 833-843
    • Santen, R.J.1    Willin III, P.W.2    Fajans, S.S.3
  • 44
    • 70349132651 scopus 로고    scopus 로고
    • Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: The LANCET randomized trial
    • Pradhan AD, Everett BM, Cook NR, Rifai N, Ridker PM. Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial. JAMA. 2009;302(11):1186-1196.
    • (2009) JAMA , vol.302 , Issue.11 , pp. 1186-1196
    • Pradhan, A.D.1    Everett, B.M.2    Cook, N.R.3    Rifai, N.4    Ridker, P.M.5
  • 45
    • 0026530495 scopus 로고
    • Garlic and onion extracts: In vitro inhibition of adenosine deaminase
    • Koch HP, Jäger W, Hysek J, Körpert B. Garlic and onion extracts: in vitro inhibition of adenosine deaminase. Phytother Res. 1992;6(1):50-52.
    • (1992) Phytother Res , vol.6 , Issue.1 , pp. 50-52
    • Koch, H.P.1    Jäger, W.2    Hysek, J.3    Körpert, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.