3,5-Dimethoxy-4-(3-(2-carbonyl-ethyldisulfanyl)-propionyl)-benzoic acid 4-guanidino-butyl ester: A novel twin drug that prevents primary cardiac myocytes from hypoxia-induced apoptosis

European Journal of Pharmacology

Volumn 700, Issue 1-3, 2013, Pages 118-126

  Liu, Chunhua ^a,b   Guo, Wei ^a   Maerz, Stefanie ^a   Gu, Xianfeng ^a   Zhu, Yizhun ^a  

^a FUDAN UNIVERSITY   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

Apoptosis; Cardioprotective effect; Hypoxia; Leonurine; Primary cardiac myocytes; Twin drug

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3,5 DIMETHOXY 4 [3 (2 CARBONYL ETHYDISULFANYL) PROPIONYL] BENZOIC ACID 4 GUANIDINO BUTYL ESTER; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANNEXIN; CARDIAC AGENT; CASPASE 3; CREATINE KINASE; LACTATE DEHYDROGENASE; LEONURINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HEART PROTECTION; LACTATE DEHYDROGENASE BLOOD LEVEL; MITOCHONDRIAL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STAINING; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; APOPTOSIS; BENZOIC ACID; CELL DEATH; CELL HYPOXIA; CREATINE KINASE; CYTOPROTECTION; DISULFIDES; GALLIC ACID; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84872911949     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.11.028     Document Type: Article

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