Associations between visceral adipose tissue, inflammation and sex steroid concentrations in men

Clinical Endocrinology

Volumn 78, Issue 3, 2013, Pages 373-378

  Gautier, Alain ^a,b   Bonnet, Fabrice ^a,b   Dubois, Séverine ^c   Massart, Catherine ^d   Grosheny, Catherine ^a,b   Bachelot, Anne ^e,f   Aubé, Christophe ^c   Balkau, Beverley ^g   Ducluzeau, Pierre Henri ^c  

^a SERVICE DE RHUMATOLOGIE   (France)

^b Univ Rennes   (France)

^c UNIVERSITÉ D'ANGERS   (France)

^d UNIVERSITÉ DE RENNES 1   (France)

^e ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^f Centre de Référence des Maladies Endocriniennes Rares de la Croissance   (France)

^g CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; CHOLESTEROL; CREATININE; ESTRADIOL; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ABDOMINAL OBESITY; ABDOMINAL SUBCUTANEOUS FAT; ADULT; AGED; ARTICLE; BODY MASS; CLINICAL TRIAL; ESTRADIOL BLOOD LEVEL; FEMALE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; AGED; ESTRADIOL; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; STEROIDS; TESTOSTERONE;

EID: 84872903012     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2012.04401.x     Document Type: Article

References (35)

1. Zumoff, B., Strain, G.W., Miller, L.K., et al,. (1990) Plasma free and non-sex-hormone-binding-globulin-bound testosterone are decreased in obese men in proportion to their degree of obesity. Journal of Clinical Endocrinology and Metabolism, 71, 929-931.
2. Seidell, J.C., Bjorntorp, P., Sjostrom, L., et al,. (1990) Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism, 39, 897-901. (Pubitemid 20293933)
3. Haffner, S.M., Valdez, R.A., Stern, M.P., et al,. (1993) Obesity, body fat distribution and sex hormones in men. International Journal of Obesity and Related Metabolic Disorders, 17, 643-649. (Pubitemid 23340277)
4. Couillard, C., Gagnon, J., Bergeron, J., et al,. (2000) Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE Family Study. Journal of Clinical Endocrinology and Metabolism, 85, 1026-1031. (Pubitemid 32269344)
5. Schneider, G., Kirschner, M.A., Berkowitz, R., et al,. (1979) Increased estrogen production in obese men. Journal of Clinical Endocrinology and Metabolism, 48, 633-638. (Pubitemid 9167803)
6. Selvin, E., Feinleib, M., Zhang, L., et al,. (2007) Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care, 30, 234-238. (Pubitemid 46198324)
7. Li, C., Ford, E.S., Li, B., et al,. (2010) Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care, 33, 1618-1624.
8. Kupelian, V., Hayes, F.J., Link, C.L., et al,. (2008) Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. Journal of Clinical Endocrinology and Metabolism, 93, 3403-3410.
9. Tchernof, A., Despres, J.P., Dupont, A., et al,. (1995) Relation of steroid hormones to glucose tolerance and plasma insulin levels in men. Importance of visceral adipose tissue. Diabetes Care, 18, 292-299.
10. Abate, N., Haffner, S.M., Garg, A., et al,. (2002) Sex steroid hormones, upper body obesity, and insulin resistance. Journal of Clinical Endocrinology and Metabolism, 87, 4522-4527. (Pubitemid 35247035)
11. Festa, A., D'Agostino Jr, R., Williams, K., et al,. (2001) The relation of body fat mass and distribution to markers of chronic inflammation. International Journal of Obesity and Related Metabolic Disorders, 25, 1407-1415. (Pubitemid 32977855)
12. Nakhai Pour, H.R., Grobbee, D.E., Muller, M., et al,. (2007) Association of endogenous sex hormone with C-reactive protein levels in middle-aged and elderly men. Clinical Endocrinology (Oxford), 66, 394-398. (Pubitemid 46239299)
13. Bhatia, V., Chaudhuri, A., Tomar, R., et al,. (2006) Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes. Diabetes Care, 29, 2289-2294. (Pubitemid 44899867)
14. Alberti, K.G., Zimmet, P., &, Shaw, J., (2005) The metabolic syndrome-a new worldwide definition. Lancet, 366, 1059-1062. (Pubitemid 41338752)
15. Matthews, D.R., Hosker, J.P., Rudenski, A.S., et al,. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419. (Pubitemid 15018832)
16. Vermeulen, A., Verdonck, L., &, Kaufman, J.M., (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism, 84, 3666-3672. (Pubitemid 30645223)
17. Illouz, F., Roulier, V., Rod, A., et al,. (2008) Distribution of adipose tissue: quantification and relationship with hepatic steatosis and vascular profiles of type 2 diabetic patients with metabolic syndrome. Diabetes & Metabolism, 34, 68-74.
18. Considine, R.V., Sinha, M.K., Heiman, M.L., et al,. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine, 334, 292-295. (Pubitemid 26033933)
19. Nielsen, T.L., Hagen, C., Wraae, K., et al,. (2007) Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men. Journal of Clinical Endocrinology and Metabolism, 92, 2696-2705. (Pubitemid 47037378)
20. Zhao, Y., Agarwal, V.R., Mendelson, C.R., et al,. (1997) Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture. Journal of Steroid Biochemistry and Molecular Biology, 61, 203-210. (Pubitemid 27455679)
21. Irahara, N., Miyoshi, Y., Taguchi, T., et al,. (2006) Quantitative analysis of aromatase mRNA expression derived from various promoters (I.4, I.3, PII and I.7) and its association with expression of TNF-alpha, IL-6 and COX-2 mRNAs in human breast cancer. International Journal of Cancer, 118, 1915-1921.
22. Subbaramaiah, K., Howe, L.R., Bhardwaj, P., et al,. (2011) Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prevention Research, 4, 329-346.
23. Chow, J.D., Jones, M.E., Prelle, K., et al,. (2011) A selective estrogen receptor alpha agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. Journal of Endocrinology, 210, 323-334.
24. George, J.T., Millar, R.P., &, Anderson, R.A., (2010) Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. Neuroendocrinology, 91, 302-307.
25. Veldhuis, J.D., &, Dufau, M.L., (1987) Oestradiol modulates the pulsatile secretion of biologically active luteinizing hormone in man. The Journal of Clinical Investigation, 80, 631-638. (Pubitemid 18003931)
26. Finkelstein, J.S., Whitcomb, R.W., O'Dea, L.S., et al,. (1991) Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men. Journal of Clinical Endocrinology and Metabolism, 73, 609-620. (Pubitemid 21921916)
27. Hayes, F.J., Seminara, S.B., Decruz, S., et al,. (2000) Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback. Journal of Clinical Endocrinology and Metabolism, 85, 3027-3035.
28. Dhindsa, S., Furlanetto, R., Vora, M., et al,. (2011) Oestradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes. Diabetes Care, 34, 1854-1859.
29. Russell, S.H., Small, C.J., Stanley, S.A., et al,. (2001) The in vitro role of tumour necrosis factor-alpha and interleukin-6 in the hypothalamic-pituitary gonadal axis. Journal of Neuroendocrinology, 13, 296-301. (Pubitemid 32170995)
30. Vikan, T., Schirmer, H., Njolstad, I., et al,. (2010) Low testosterone and sex hormone-binding globulin levels and high oestradiol levels are independent predictors of type 2 diabetes in men. European Journal of Endocrinology, 162, 747-754.
31. Turhan, S., Tulunay, C., Gulec, S., et al,. (2007) The association between androgen levels and premature coronary artery disease in men. Coronary Artery Disease, 18, 159-162. (Pubitemid 46608491)
32. Tivesten, A., Hulthe, J., Wallenfeldt, K., et al,. (2006) Circulating oestradiol is an independent predictor of progression of carotid artery intima-media thickness in middle-aged men. Journal of Clinical Endocrinology and Metabolism, 91, 4433-4437. (Pubitemid 44833419)
33. Arnlov, J., Pencina, M.J., Amin, S., et al,. (2006) Endogenous sex hormones and cardiovascular disease incidence in men. Annals of Internal Medicine, 145, 176-184. (Pubitemid 46780562)
34. Liuzzo, G., Biasucci, L.M., Gallimore, J.R., et al,. (1994) The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. New England Journal of Medicine, 331, 417-424. (Pubitemid 24247397)
35. Abbott, R.D., Curb, J.D., Rodriguez, B.L., et al,. (2002) Age-related changes in risk factor effects on the incidence of coronary heart disease. Annals of Epidemiology, 12, 173-181. (Pubitemid 34189719)