Effects of iron supplementation of lbw infants on cognition and behavior at 3 years

Pediatrics

Volumn 131, Issue 1, 2013, Pages 47-55

  Berglund, Staffan K ^a   Westrup, Björn ^b   Hägglöf, Bruno ^a   Hernell, Olle ^a   Domellöf, Magnus ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Behavioral problems; Children; Cognitive score; Infant; Iron; Iron deficiency; Iron deficiency anemia; Low birth weight; Neurodevelopment; Preterm; Randomized controlled trial; Small for gestational age

Indexed keywords

FERROUS SUCCINATE; PLACEBO;

ARTICLE; BEHAVIOR DISORDER; CHILD; CHILD BEHAVIOR CHECKLIST; COGNITIVE DEFECT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EARLY INTERVENTION; FEMALE; HUMAN; INFANT; INTELLIGENCE QUOTIENT; IRON THERAPY; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WECHSLER INTELLIGENCE SCALE;

ADMINISTRATION, ORAL; AGE FACTORS; CHILD BEHAVIOR; CHILD, PRESCHOOL; COGNITION; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FERROUS COMPOUNDS; FOLLOW-UP STUDIES; HUMANS; INFANT; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; IRON; MALE; TREATMENT OUTCOME; WECHSLER SCALES;

EID: 84872872628     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2012-0989     Document Type: Article

References (36)

1. The state of the world's children 2009: Maternal and newborn health. UNICEF: 2009. Available at: Www.unicef.org/protection/SOWC09-FullReport-EN.pdf. Accessed December 1, 2011
2. McCormick MC. The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med. 1985;312(2): 82-90
3. Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJ. Cognitive and behavioral outcomes of school-aged children who were born preterm: A meta-analysis. JAMA. 2002;288(6):728-737
4. Lindström K, Lindblad F, Hjern A. Preterm birth and attention-deficit/hyperactivity disorder in schoolchildren. Pediatrics. 2011;127(5):858-865
5. Loe IM, Lee ES, Luna B, Feldman HM. Behavior problems of 9-16 year old preterm children: Biological, sociodemographic, and intellectual contributions. Early Hum Dev. 2011;87(4):247-252
6. Boulet SL, Schieve LA, Boyle CA. Birth weight and health and developmental outcomes in US children, 1997-2005. Matern Child Health J. 2011;15(7):836-844
7. Pietz J, Peter J, Graf R, et al. Physical growth and neurodevelopmental outcome of nonhandicapped low-risk children born preterm. Early Hum Dev. 2004;79(2):131-143
8. van Os J, Wichers M, Danckaerts M, Van Gestel S, Derom C, Vlietinck R. A prospective twin study of birth weight discordance and child problem behavior. Biol Psychiatry. 2001;50(8):593-599
9. Gray RF, Indurkhya A, McCormick MC. Prevalence, stability, and predictors of clinically significant behavior problems in low birth weight children at 3, 5, and 8 years of age. Pediatrics. 2004;114(3):736-743
10. Martin JA, Hamilton BE, Sutton PD, et al. Births: Final data for 2005. Natl Vital Stat Report. 2007;56(6):1-103
11. Birth statistics: Births and patterns of family building in England and Wales 2007: Office for National Statistics; 2008. Available at: Www.official-documents.gov.uk/document/other/9787777148210/9787777148210.pdf. Accessed December 1, 2011
12. Martin JA, Kirmeyer S, Osterman M, Shepherd RA. Born a bit too early: Recent trends in late preterm births. NCHS Data Brief. 2009;(24):1-8
13. Iron deficiency anaemia: Assessment, prevention and control. A guide for programme managers. Geneva, Switzerland: World Health Organization; 2001. Available at: Http://whqlibdoc.who.int/hq/2001/WHO-NHD-01.3.pdf. Accessed December 1, 2011
14. Walker SP, Wachs TD, Grantham-McGregor S, et al. Inequality in early childhood: Risk and protective factors for early child development. Lancet. 2011;378(9799):1325-1338
15. McCann JC, Ames BN. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr. 2007;85(4):931-945
16. Edmond K, Bahl R. Optimal feeding of lowbirth weight infants. Geneva, Switzerland: World Health Organization; 2006. Available at: Http://whqlibdoc. who.int/publications/2006/9789241595094-eng.pdf. Accessed December 1, 2011
17. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Community-based, randomised, placebocontrolled trial. Lancet. 2006;367(9505):133-143
18. Dewey KG, Domellöf M, Cohen RJ, Landa Rivera L, Hernell O, Lönnerdal B. Iron supplementation affects growth and morbidity of breast-fed infants: Results of a randomized trial in Sweden and Honduras. J Nutr. 2002;132(11):3249-3255
19. Lozoff B, Castillo M, Clark KM, Smith JB. Iron-fortified vs low-iron infant formula: Developmental outcome at 10 years. Arch Pediatr Adolesc Med. 2012;166(3):208-215
20. Berglund S, Westrup B, Domellöf M. Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants. Pediatrics. 2010;126(4). Available at: Www.pediatrics.org/cgi/content/full/126/4/e874
21. Achenbach TM, Rescorla LA. Manual for the ASEBA Preschool Forms & Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families; 2000
22. Berglund SK, Lönnerdal B, Westrup B, Domellöf M. Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants. Am J Clin Nutr. 2011;94(6):1553-1561
23. Saarinen UM, Siimes MA. Developmental changes in red blood cell counts and indices of infants after exclusion of iron deficiency by laboratory criteria and continuous iron supplementation. J Pediatr. 1978;92(3):412-416
24. Domellöf M, Dewey KG, Lönnerdal B, Cohen RJ, Hernell O. The diagnostic criteria for iron deficiency in infants should be reevaluated. J Nutr. 2002;132(12):3680-3686
25. Saarinen UM, Siimes MA. Developmental changes in serum iron, total iron-binding capacity, and transferrin saturation in infancy. J Pediatr. 1977;91(6):875-877
26. Saarinen UM, Siimes MA. Serum ferritin in assessment of iron nutrition in healthy infants. Acta Paediatr Scand. 1978;67(6): 745-751
27. Berntsson L. Health and Well-Being of Children in the Five Nordic Countries in 1984 and 1996 [doctoral dissertation]. Gothenburg, Sweden: Nordic School of Public Health; 2000
28. Höök B, Cederblad M. Assessment of CBCL in Swedish Preschool Children [in Swedish]. Report 4. Umeå, Sweden: Umeå University; 2008
29. Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet. 2005;366 (9481):237-248
30. Mick E, Biederman J, Prince J, Fischer MJ, Faraone SV. Impact of low birth weight on attention-deficit hyperactivity disorder. J Dev Behav Pediatr. 2002;23(1):16-22
31. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64(5 pt 2):S34-S43; discussion S72-S91
32. Corapci F, Calatroni A, Kaciroti N, Jimenez E, Lozoff B. Longitudinal evaluation of externalizing and internalizing behavior problems following iron deficiency in infancy. J Pediatr Psychol. 2010;35(3):296-305
33. Szajewska H, Ruszczynski M, Chmielewska A. Effects of iron supplementation in nonanemic pregnant women, infants, and young children on the mental performance and psychomotor development of children: A systematic review of randomized controlled trials. Am J Clin Nutr. 2010;91(6): 1684-1690
34. Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol. 2006;13(3):158-165
35. Aggett PJ, Agostoni C, Axelsson I, et al. Iron metabolism and requirements in early childhood: Do we know enough? A commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2002;34(4):337-345
36. Domellöf M. Benefits and harms of iron supplementation in iron-deficient and ironsufficient children. Nestle Nutr Workshop Ser Pediatr Program. 2010;65:153-162; discussion 162-165