The diagnostic criteria for iron deficiency in infants should be reevaluated

Journal of Nutrition

Volumn 132, Issue 12, 2002, Pages 3680-3686

  Domellöf, Magnus ^a   Dewey, Kathryn G ^b   Lönnerdal, Bo ^b   Cohen, Roberta J ^b   Hernell, Olle ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ferritin; Hemoglobin; Infants; Iron deficiency anemia; Reference values; Transferrin receptors

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON; PLACEBO; PROTOPORPHYRIN ZINC; TRANSFERRIN RECEPTOR;

ARTICLE; BLOOD SAMPLING; BREAST FEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ERYTHROCYTE LEVEL; FERRITIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HONDURAS; HUMAN; INFANT; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON THERAPY; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SWEDEN;

EID: 18744382115     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.12.3680     Document Type: Article

References (31)

1. Fairweather-Tait S. J. (1996) Iron deficiency anaemia: Epidemiology, complications, diagnosis and management. Int. Sem. Paediatr. Gastroenterol. Nutr. 5: 3-7.
2. Roncagliolo, M., Garrido, M., Walter, T., Peirano, P. & Lozoff, B. (1998) Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: Delayed maturation of auditory brainstem responses. Am. J. Clin. Nutr. 68: 683-690.
3. Idjradinata, P. & Pollitt E. (1993) Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet 341: 1-4.
4. Grantham-McGregor, S. M. & Ani, C. C. (1999) The role of micronutrients in psychomotor and cognitive development. Br. Med. Bull. 55: 511-527.
5. Hallberg, L., Bengtsson, C., Lapidus, L., Lindstedt, G., Lundberg P. A. & Hulten, L. (1993) Screening for iron deficiency: An analysis based on bone-marrow examinations and serum ferritin determinations in a population sample of women. Br. J. Haematol. 85: 787-798.
6. Cook, J. D., Finch, C. A. & Smith, N. J. (1976) Evaluation of the iron status of a population. Blood 48: 449-455.
7. Worwood, M. (1997) The laboratory assessment of iron status - An update. Clin. Chim. Acta 259: 3-23.
8. Garby, L., Irnell, L. & Werner, I. (1969) Iron deficiency in women of fertile age in a Swedish community. II. Efficiency of several laboratory tests to predict the response to iron supplementation. Acta Med. Scand. 185: 107-111.
9. Oski, F. A. (1993) Iron deficiency in infancy and childhood. N. Engl. J. Med. 329: 190-193.
10. Centers for Disease Control and Prevention (CDC) (1998) Recommendations to prevent and control iron deficiency in the United States. Morb. Mortal. Wkly. Rep. 47: 1-29.
11. International Nutritional Anemia Consultative Group (INACG), World Health Organization (WHO) and United Nations Children's Fund (UNICEF). (1998) Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia. International Life Sciences Institute, Washington, DC.
12. Michaelsen, K. F., Weaver, L., Branca, F. & Robertson, A. (2000) Control of iron deficiency. In: Feeding and Nutrition of Infants and Young Children. Guidelines for the WHO European Region, pp. 101-122. WHO, Copenhagen, Denmark.
13. Looker, A. C., Dallman, P. R., Carroll, M. D., Gunter, E. W. & Johnson, C. L. (1997) Prevalence of iron deficiency in the United States. J. Am. Med. Assoc. 277: 973-976.
14. Emond, A. M., Hawkins, N., Pennock, C. & Golding, J. (1996) Haemoglobin and ferritin concentrations in infants at 8 months of age. Arch. Dis. Child. 74: 36-39.
15. Aggett, P. J., Agostoni, C., Axelsson, I., Bresson, J. L., Goulet, O., Hernell, O., Koletzko, B., Lafeber, H. L., Michaelsen, K. F., Micheli, J. L., Rigo, J., Szajewska, H. & Weaver, L. T. (2002) Iron metabolism and needs in early childhood: Do we know enough? A commentary by the ESPGHAN Committee on Nutrition. J. Pediatr. Gastroenterol. Nutr 34: 337-34.
16. American Academy of Pediatrics Working Group on Breastfeeding (1997) Breastfeeding and the use of human milk. Pediatrics 100: 1035-1039.
17. World Health Assembly (WHA) (2001) Infant and Young Child Nutrition. Resolution WHA 54.2. WHO, Geneva, Switzerland.
18. Domellöf, M., Cohen, R. J., Dewey, K. G., Hernell, O., Rivera, L. L. & Lönnerdal, B. (2001) Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age. J. Pediatr. 138: 679-687.
19. Farr, B. M. & Shapiro, D. E. (2000) Diagnostic tests: Distinguishing good tests from bad and even ugly ones. Infect. Control Hosp. Epidemiol. 21: 278-284.
20. Saarinen, U. M. & Siimes, M. A. (1978) Developmental changes in red blood cell counts and indices of infants after exclusion of iron deficiency by laboratory criteria and continuous iron supplementation. J. Pediatr. 92: 412-416.
21. Sturgeon, P. (1956) Studies of iron requirements in infants and children. II. The influence on normal infants of oral iron in therapeutic doses. Pediatrics 17: 341-348.
22. Lönnerdal, B. & Hernell, O. (1994) Iron, zinc, copper and selenium status of breast-fed infants and infants fed trace element fortified milk-based infant formula. Acta Paediatr. 83: 367-373.
23. Domellöf, M., Lönnerdal, B., Abrams, S. A. & Hernell, O. (2002) Iron absorption in breast-fed infants: Effect of age, iron status, iron supplements and complementary foods. Am. J. Clin. Nutr 76: 198-204.
24. Rettmer, R. L., Carlson, T. H., Origenes, M. L., Jack, R. M. & Labb, R. F. (1999) Zinc protoporphyrin/heme ratio for diagnosis of preanemic iron deficiency. Pediatrics 104: e37.
25. Saarinen, U. M. & Siimes, M. A. (1978) Serum ferritin in assessment of iron nutrition in healthy infants. Acta Paediatr. Scand. 67: 745-751.
26. Virtanen, M. A., Viinikka, L. U., Virtanen, M. K., Svahn, J. C., Anttila, R. M., Krusius, T., Cook, J. D., Axelsson, I. E., Raiha, N. C. & Siimes, M. A. (1999) Higher concentrations of serum transferrin receptor in children than in adults. Am. J. Clin. Nutr 69: 256-260.
27. Olivares, M., Walter, T., Cook, J. D., Hertrampf, E. & Pizarro, F. (2000) Usefulness of serum transferrin receptor and serum ferritin in diagnosis of iron deficiency in infancy. Am. J. Clin. Nutr 72: 1191-1195.
28. Åkesson, A., Bjellerup, P. & Vahter, M. (1999) Evaluation of kits for measurement of the soluble transferrin receptor. Scand. J. Clin. Lab. investig. 59: 77-81.
29. Domellöf, M., Lönnerdal, B., Dewey, K. G., Cohen, R. J., Rivera, L. L. & Hernell, O. (2002) Sex differences in iron status during infancy. Pediatrics 110: 545-552.
30. Dallman, P. R., Siimes, M. A. & Stekel, A. (1980) Iron deficiency in infancy and childhood. Am. J. Clin. Nutr 33: 86-118.
31. Brugnara, C. & Platt, O. P. (1998) The neonatal erythrocyte and its disorders. In: Nathan and Oski's Hematology of Infancy and Childhood, 5th Ed. (Nathan, D. G. & Orkin, S. H., eds.), pp. 19-52, W. B. Saunders Company, Philadelphia, PA.