Metabolic profile analysis of zebrafish embryos

Journal of Visualized Experiments

Volumn , Issue 71, 2013, Pages

  Gibert, Yann ^a,b   McGee, Sean L ^a,b   Ward, Alister C ^a,b  

^a Metabolic Research Unit and Molecular and Medical Research SRC   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

Author keywords

Animal model; ATP; Biochemistry; Cellular biology; Danio rerio; Development; Developmental biology; Embryology; Genetics; Issue 71; Metabolic profile; Metabolism; Metabolomics; Mitochondria; Molecular biology; Oil red o staining; Physiology; Respiration; Zebrafish

Indexed keywords

EID: 84872863687     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/4300     Document Type: Article

References (12)

1. Nüsslein-Volhard, C. & Dahm, R. Zebrafish. Oxford University Press, (2002).
2. Schlombs, K., Wagner, T., & Scheel, J. Site-1 protease is required for cartilage development in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 100, 14024-14029 (2003).
3. Ingham, P.W. The power of the zebrafish for disease analysis. Hum. Mol. Genet. 18, R107-112 (2009).
4. Nasevicius, A. & Ekker, S.C. Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26, 216-220 (2000).
5. Stackley, K.D., Beeson, C.C., Rahn, J.J., & Chan, S.S. Bioenergetic profiling of zebrafish embryonic development. Plos One. 6, e25652 (2011).
6. McGee, S.L., Sadli, N., Morrison, S., Swinton, C., & Suphioglu, C. DHA protects against zinc mediated alterations in neuronal cellular bioenergetics. Cell Physiol. Biochem. 28, 157-162 (2011).
7. Sivitz, W.I. & Yorek, M.A. Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid. Redox Signal. 12, 537-577 (2010).
8. Bournat, J.C. & Brown, C.W. Mitochondrial dysfunction in obesity. Curr. Opin. Endocrinol. Diabetes Obes. 17, 446-452 (2010).
9. Ghafourifar, P., et al. Mitochondria in multiple sclerosis. Front Biosci. 13, 3116-3126 (2008).
10. Winklhofer, K.F. & Haass, C. Mitochondrial dysfunction in Parkinson's disease. Biochim. Biophys. Acta. 1802, 29-44 (2010).
11. Maruszak, A. & Zekanowski, C. Mitochondrial dysfunction and Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry. 35, 320-330 (2011).
12. de Moura, M.B., dos Santos, L.S., & Van Houten, B. Mitochondrial dysfunction in neurodegenerative diseases and cancer. Environ. Mol. Mutagen. 51, 391-405 (2010).