Senescent endothelial dysfunctions were mediated by SIP2 receptor in cultured human umbilical vein endothelial cells

Journal of Central South University (Medical Sciences)

Volumn 37, Issue 12, 2012, Pages 1239-1245

  Chen, Shuhua ^a,b   Xiang, Hong ^a   Yang, Guoping ^a   Deng, Hao ^a   Yuan, Hong ^a   Lü, Hongwei ^a  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Aging; Endothelial cells; RNA interference; S1P2 receptor

Indexed keywords

S1PR2 PROTEIN, HUMAN; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ARTICLE; CELL AGING; CELL CULTURE; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

CELL AGING; CELLS, CULTURED; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; RECEPTORS, LYSOSPHINGOLIPID; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; UP-REGULATION;

EID: 84872842980     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1672-7347.2012.12.010     Document Type: Article

References (21)

1. Erusalimsky JD, Kurz DJ. Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease[J]. Exp Gerontol, 2005, 40(8/9): 634-642. (Pubitemid 41265813)
2. Behrendt D, Ganz P. Endothelial function: From vascular biology to clinical application[J]. Am J Cardiol, 2002, 90( suppl II) : 40-48.
3. HUANG Yali, LU Tong. Ageing and endothelial dysfunction[J]. Adv Cardiovasc Dis, 2007, 28( 5): 766-770.
4. Yatomi Y. Sphingosine 1-phosphate in vascular biology: Possible therapeutic strategies to control vascular diseases[J]. Curr Pharm Des, 2006, 12( 5): 575-587.
5. Tani M, Kawakami A, Nagai M, et al. Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity[J]. FEBS Lett, 2007, 581 (24): 4621-4626. (Pubitemid 47418787)
6. Lee MJ, Thangada S, Claffey KP, et al. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1phosphate[J]. Cell, 1999, 99(3): 301-312. (Pubitemid 29519909)
7. Lee MJ, Thangada S, Paik JH, et al. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis[J]. Mol Cell, 2001, 8(3): 693-704. (Pubitemid 32946945)
8. Lee JF, Zeng Q, Ozaki H, et al. Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial Chemotaxis and barrier integrity[J]. J Biol Chem, 2006, 281(39): 29190-29200. (Pubitemid 44507063)
9. Sanchez T, Skoura A, Wu MT, et al. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN[J]. Arterioscler Thromb Vase Biol, 2007, 27(6): 1312-1318. (Pubitemid 46809419)
10. Garcia JG, Liu F, Verin AD, et al. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement[J].J Clin Invest, 2001, 108(5): 689-701. (Pubitemid 32906197)
11. LU Hongwei, CHEN Shuhua, YANG Guoping, et al. Correlation between S1P2 receptor expression and functional changes in the ageing process of vascular endothelial cells[J]. Chinese Journal of Gerontology, 2009, 29( 4): 404-406.
12. LU Hongwei, CHEN Shuhua, YANG Guoping, et al. Construction and screening of the recombinant adenovirus vector with S1P2 receptortargeted shRNA[J]. Chinese Journal of Gerontology, 2009, 29( 5): 513-516.
13. Shimizu T, Nakazawa T, Cho A, et al. Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries[J]. Circ Res, 2007, 101(10): 995-1000. (Pubitemid 350110273)
14. Lorenz JN, Arend LJ, Robitz R, et al. Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice[J]. Am J Physiol Regul Integr Comp Physiol, 2007, 292(1): R440-446. (Pubitemid 46089859)
15. Inoki I, Takuwa N, Sugimoto N, et al. Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor[J]. Biochem Biophys Res Commun, 2006, 346(1): 293-300. (Pubitemid 43865997)
16. Kimura T, Watanabe T, Sato K, et al. Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3[J]. Biochem J, 2000, 348(1): 71-76. (Pubitemid 30312132)
17. Kono M, Mi Y, Liu Y, et al. The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis[J]. J Biol Chem, 2004, 279(28): 29367-29373. (Pubitemid 38915815)
18. Gorshkova I, He D, Berdyshev E, et al. Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and racl [J]. J Biol Chem, 2008, 283( 17): 11794-11806.
19. Lee JF, Gordon S, Estrada R, et al. Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature[J]. AmJ Physiol Heart Circ Physiol, 2009, 296( 1): H33-42.
20. Estrada R, Zeng Q, Lu H, et al. Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial Cells[J] J Biol Chem, 2008, 283( 44): 30363-30375.
21. Lu H, Yuan H, Chen S, et al. Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats[J]. Mol Cell Biochem, 2012, 63( 1/ 2): 217-224.