Chronic Alcohol Exposure Renders Epithelial Cells Vulnerable to Bacterial Infection

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Wood, Stephen ^a   Pithadia, Ravi ^a   Rehman, Tooba ^a   Zhang, Lijuan ^a   Plichta, Jennifer ^b   Radek, Katherine A ^b   Forsyth, Christopher ^a   Keshavarzian, Ali ^a   Shafikhani, Sasha H ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL;

ALCOHOL CONSUMPTION; ARTICLE; BACTERIAL INFECTION; CELL DAMAGE; CELL MIGRATION; CELL STRAIN CACO 2; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY TEST; DISEASE ASSOCIATION; INFECTION RISK; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; LONG TERM EXPOSURE; NONHUMAN; PHENOTYPE;

ADHERENS JUNCTIONS; BACTERIAL INFECTIONS; CACO-2 CELLS; DISEASE SUSCEPTIBILITY; ETHANOL; HUMANS; INTESTINAL MUCOSA; MODELS, THEORETICAL; TIGHT JUNCTIONS;

BACTERIA (MICROORGANISMS); RODENTIA;

EID: 84872840869     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054646     Document Type: Article

References (46)

1. Elamin E, Jonkers D, Juuti-Uusitalo K, van Ijzendoorn S, Troost F, et al. (2012) Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model. PLoS One 7: e35008.
2. Ma TY, Nguyen D, Bui V, Nguyen H, Hoa N, (1999) Ethanol modulation of intestinal epithelial tight junction barrier. The American journal of physiology 276: G965-974.
3. Banan A, Choudhary S, Zhang Y, Fields JZ, Keshavarzian A, (1999) Ethanol-induced barrier dysfunction and its prevention by growth factors in human intestinal monolayers: evidence for oxidative and cytoskeletal mechanisms. The Journal of pharmacology and experimental therapeutics 291: 1075-1085.
4. Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, et al. (2009) Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J Hepatol 50: 538-547.
5. Ferrier L, Berard F, Debrauwer L, Chabo C, Langella P, et al. (2006) Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents. Am J Pathol 168: 1148-1154.
6. Keshavarzian A, Fields JZ, Vaeth J, Holmes EW, (1994) The differing effects of acute and chronic alcohol on gastric and intestinal permeability. Am J Gastroenterol 89: 2205-2211.
7. Simet SM, Wyatt TA, DeVasure J, Yanov D, Allen-Gipson D, et al. (2012) Alcohol increases the permeability of airway epithelial tight junctions in Beas-2B and NHBE cells. Alcohol Clin Exp Res 36: 432-442.
8. Rao R, (2009) Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology 50: 638-644.
9. Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, et al. (2008) Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol 42: 349-361.
10. Rush B (1814) An inquiry into the effects of ardent spirits upon the human body and mind with an account of the means of preventing and of the remedies for curing them. 321-341 p.
11. Nolan JP, (1965) Alcohol as a factor in the illness of university service patients. Am J Med Sci 249: 135-142.
12. Kolb D, Gunderson EK, (1982) Alcohol-related morbidity among older career navy men. Drug Alcohol Depend 9: 181-189.
13. Murdoch EL, Karavitis J, Deburghgraeve C, Ramirez L, Kovacs EJ, (2011) Prolonged chemokine expression and excessive neutrophil infiltration in the lungs of burn-injured mice exposed to ethanol and pulmonary infection. Shock 35: 403-410.
14. Huang DB, Sanchez AP, Triana E, Jiang ZD, DuPont HL, et al. (2004) United States male students who heavily consume alcohol in Mexico are at greater risk of travelers' diarrhea than their female counterparts. J Travel Med 11: 143-145.
15. Smith FE, Palmer DL, (1976) Alcoholism, infection and altered host defenses: a review of clinical and experimental observations. J Chronic Dis 29: 35-49.
16. Tillotson JR, Lerner AM, (1966) Pneumonias caused by gram negative bacilli. Medicine (Baltimore) 45: 65-76.
17. Lerner AM, Tillotson JR, (1968) Pneumonias caused by gram-negative bacilli. Mich Med 67: 35-38.
18. Aguado Garcia JM, Fernandez Guerrero ML, Diaz Curiel M, Collazos Gonzalez J, Molins Otero A, et al. (1984) [Bacteremic pneumonias caused by gram-negative aerobic bacilli in the adult. Apropos of 35 cases]. Rev Clin Esp 174: 85-89.
19. Spach DH, Kanter AS, Dougherty MJ, Larson AM, Coyle MB, et al. (1995) Bartonella (Rochalimaea) quintana bacteremia in inner-city patients with chronic alcoholism. N Engl J Med 332: 424-428.
20. Szabo G, Bala S, (2010) Alcoholic liver disease and the gut-liver axis. World J Gastroenterol 16: 1321-1329.
21. Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, et al. (2004) The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Infect Immun 72: 546-558.
22. Wood S, Sivaramakrishnan G, Engel J, Shafikhani SH, (2011) Cell migration regulates the kinetics of cytokinesis. Cell Cycle 10: 648-654.
23. Shafikhani S, Morales C, Engel J, (2008) The Pseudomonas aeruginosa type III secreted toxin ExoT is necessary and sufficient to induce apoptosis in epithelial cells. Cell Micro 10: 994-1007.
24. Shafikhani SH, Engel J, (2006) Pseudomonas aeruginosa type III-secreted toxin ExoT inhibits host-cell division by targeting cytokinesis at multiple steps. Proc Natl Acad Sci U S A 103: 15605-15610.
25. Kazmierczak B, Mostov K, Engel J, (2001) Interaction of bacterial pathogens with polarized epithelium. Ann Rev Microbiol 55: 407-435.
26. Robson MC, (1997) Wound infection. A failure of wound healing caused by an imbalance of bacteria. Surg Clin North Am 77: 637-650.
27. Edwards R, Harding KG, (2004) Bacteria and wound healing. Curr Opin Infect Dis 17: 91-96.
28. Jones SG, Edwards R, Thomas DW, (2004) Inflammation and wound healing: the role of bacteria in the immuno-regulation of wound healing. Int J Low Extrem Wounds 3: 201-208.
29. Stephens P, Wall IB, Wilson MJ, Hill KE, Davies CE, et al. (2003) Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. Br J Dermatol 148: 456-466.
30. Fink SL, Cookson BT, (2005) Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 73: 1907-1916.
31. Gao L, Abu Kwaik Y, (2000) Hijacking of apoptotic pathways by bacterial pathogens. Microbes Infect 2: 1705-1719.
32. Labbe K, Saleh M, (2008) Cell death in the host response to infection. Cell Death Differ 15: 1339-1349.
33. Hauser A, Engel J, (1999) Pseudomonas aeruginosa induces Type III secretion-mediated apoptosis in macrophages and epithelial cells. Infect Immun 67: 5530-5537.
34. Hauser AR, Cobb E, Bodi M, Mariscal D, Valles J, et al. (2002) Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Crit Care Med 30: 521-528.
35. Bode JC, Parlesak A, Bode C (2001) Gut-derived bacterial toxins (endotoxin) and alcoholic liver disease. In: P AD, K SH, editors. Alcohol in Health and Disease: New York-Basel. 369-386.
36. Bode JC, Bode C, Heidelbach R, Durr HK, Martini GA, (1984) Jejunal microflora in patients with chronic alcohol abuse. Hepatogastroenterology 31: 30-34.
37. Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG, (1995) Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108: 218-224.
38. Portnoy DA, Auerbuch V, Glomski IJ, (2002) The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity. The Journal of cell biology 158: 409-414.
39. Mutlu E, Keshavarzian A, Engen P, Forsyth CB, Sikaroodi M, et al. (2009) Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol Clin Exp Res 33: 1836-1846.
40. Chiller K, Selkin BA, Murakawa GJ, (2001) Skin microflora and bacterial infections of the skin. J Investig Dermatol Symp Proc 6: 170-174.
41. Forsyth CB, Tang Y, Shaikh M, Zhang L, Keshavarzian A, (2010) Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial-mesenchymal transition in colon and breast cancer cells. Alcoholism, clinical and experimental research 34: 19-31.
42. Shaw TJ, Martin P, (2009) Wound repair at a glance. J Cell Sci 122: 3209-3213.
43. Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, et al. (2009) Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen 17: 763-771.
44. Kalluri R, Weinberg RA, (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428.
45. Forsyth CB, Tang Y, Shaikh M, Zhang L, Keshavarzian A, (2011) Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability. Alcohol Clin Exp Res 35: 1635-1643.
46. Swanson G, Forsyth CB, Tang Y, Shaikh M, Zhang L, et al. (2011) Role of intestinal circadian genes in alcohol-induced gut leakiness. Alcoholism, clinical and experimental research 35: 1305-1314.