DADS downregulates the Rac1-ROCK1/PAK1-LIMK1-ADF/cofilin signaling pathway, inhibiting cell migration and invasion

Oncology Reports

Volumn 29, Issue 2, 2013, Pages 605-612

  Zhou, Yujuan ^a   Su, Jian ^a   Shi, Ling ^a   Liao, Qianjin ^a   Su, Qi ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

Cell invasion; Cell migration; Diallyl disulfide; Signaling pathway

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; COFILIN; DIALLYL DISULFIDE; LIM KINASE 1; MESSENGER RNA; MICRORNA; P21 ACTIVATED KINASE 1; RAC1 PROTEIN; RHO KINASE; RHO KINASE 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CELL ASSAY; CELL STRAIN SW480; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MIGRATION INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WOUND HEALING;

ALLYL COMPOUNDS; CELL LINE, TUMOR; CELL MOVEMENT; COFILIN 1; COLORECTAL NEOPLASMS; DESTRIN; DISULFIDES; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; LIM KINASES; MICRORNAS; NEOPLASM INVASIVENESS; P21-ACTIVATED KINASES; RAC1 GTP-BINDING PROTEIN; RHO-ASSOCIATED KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84872808695     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2168     Document Type: Article

References (34)

1. Jemal A, Bray F, Center MM, et al: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Xu X, Johnson P and Mueller SC: Breast cancer cell movement: imaging invadopodia by TIRF and IRM microscopy. Methods Mol Biol 571: 209-225, 2009
3. Yamaguchi H and Condeelis J: Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta 1773: 642-652, 2007 (Pubitemid 46660177)
4. Ishaq M, Lin BR, Bosche M, et al: LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes. BMC Mol Biol 12: 41, 2011.
5. Salvarezza SB, Deborde S, Schreiner R, et al: LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network. Mol Biol Cell 20: 438-451, 2009
6. Kaji N, Muramoto A and Mizuno K: LIM kinase-mediated cofilin phosphorylation during mitosis is required for precise spindle positioning. J Biol Chem 283: 4983-4992, 2008.
7. San Martin A, Lee MY, Williams HC, Mizuno K, Lassegue B and Griendling KK: 1 al regulation of cofilin activity by LIM kinase and Slingshot-IL phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells. Circ Res 102: 432-438, 2008. (Pubitemid 351651101)
8. Ding Y, Milosavljevic T and Alahari SK: Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion. Mol Cell Biol 28: 3742-3756, 2008. (Pubitemid 351732909)
9. Hui C, Jun W, Ya LN and Ming X: Effect of Allium sativum (garlic) diallyl disulfide (DADS) on human non-small cell lung carcinoma H1299 cells. Trop Biomed 25: 37-45, 2008.
10. Lei XY, Yao SQ, Zu XY, Huang ZX, Liu LJ, et al: Apoptosis induce. by diallyl disulfide in human breast cancer cell line MCF-7. Acta Pharmacol Sin 29: 1233-1239, 2008.
11. Lee JE, Lee RA, Kim KH and Lee JH: Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line. J Korean Surg Soc 81: 85-95, 2011.
12. Yi L, Ji XX, Lin M, et al: Diallyl disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen. Pharmazie 65: 693-698, 2010.
13. 2+ movement and viability in PC3 human prostate cancer cells. Toxicol In Vitro 25: 636-643, 2011.
14. Liao QJ, Su J, Zhou XT, Tang HL, Song Y and Su Q: Inhibitory effect of diallyl disulfide on proliferation of human colon cancer cell line SW480 in nude mice. Ai Zheng 26: 828-832, 2007 (In Chinese).
15. Liao QJ, Su J, He J, et al: Effect of diallyl disulfide on cell cycle arrest of human colon cancer SW480 cells. Ai Zheng 28: 138-141, 2009
16. Su J, He X, Rong Y, et al: The differential proteomic expression analysis of diallyl disulfide-induced human colonic cancer cells. Chin Pharmacol Bull 22: 583-586, 2006.
17. Shi L, Su J, Liao Q, et al: Diallyl disulfide inhibits migration and invasion in human colon cancer SW480 cells by downregulating expression of LIMK1. Chin Pharmacol Bull 28: 200-205, 2011.
18. Huang YS, Xie N, Su Q, et al: Diallyl disulfide inhibits the proliferation of HT-29 human colon cancer cells by inducing differentially expressed genes. Mol Med Rep 4: 553-559, 2011.
19. Flamini MI, Fu XD, Sanchez AM, et al: Effects of raloxifene on breast cancer cell migration and invasion through the actin cytoskeleton. J Cell Mol Med 13: 2396-2407, 2009
20. Freitas VM, Rangel M, Bisson LF, Jaeger RG and Machado-Santelli GM: The geodiamolide H, derived from Brazilian sponge Geodia corticostylifera, regulates actin cytoskeleton, migration and invasion of breast cancer cells cultured in three-dimensional environment. J Cell Physiol 216: 583-594, 2008.
21. Nadella KS, Saji M, Jacob NK, et al: Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1. EMBO Rep 10: 599-605, 2009
22. Konakahara S, Ohashi K, Mizuno K, Itoh K and Tsuji T: CD29 integrin- and LIMK1/cofilin-mediated actin reorganization regulates the migration of haematopoietic progenitor cells underneath bone marrow stromal cells. Genes Cells 9: 345-358, 2004 (Pubitemid 38514870)
23. Borensztajn K, Peppelenbosch MP and Spek CA: Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation. Thromb Res 125: e323-e328, 2010.
24. Khanum F, Anilakumar KR and Viswanathan KR: Anticarcinogenic properties of garlic: a review. Crit Rev Food Sci Nutr 44: 479-488, 2004 (Pubitemid 39597803)
25. Montani L, Gerrits B, Gehrig P, et al: Neuronal Nogo-A modulates growth cone motility via Rho-GTP/LIMK1/cofilin in the unle-sioned adult nervous system. J Biol Chem 284: 10793-10807, 2009
26. Schmitz AA, Govek EE, Bottner B and Van Aelst L: Rho GTPases: signaling, migration, and invasion. Exp Cell Res 261: 1-12, 2000.
27. Edwards DC, Sanders LC, Bokoch GM and Gill GN: Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1: 253-259, 1999 (Pubitemid 129495774)
28. Zheng B, Liang L, Wang C, et al: MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res 177574-7583, 2011.
29. Wang W, Eddy R and Condeelis J: The cofilin pathway in breast cancer invasion and metastasis. Nat Rev Cancer 7: 429-440, 2007 (Pubitemid 46809168)
30. Sit ST and Manser E: Rho GTPases and their role in organizing the actin cytoskeleton. J Cell Sci 124: 679-683, 2011.
31. Van Troys M, Huyck L, Leyman S, et al: Ins and outs of ADF/cofilin activity and regulation. Eur J Cell Biol 87: 649-667, 2008.
32. Ding Z, Gau D, Deasy B, Wells A and Roy P: Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells. Exp Cell Res 315: 2963-2973, 2009
33. Bamburg JR, McGough A and Ono S: Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol 9: 364-370, 1999. (Pubitemid 29447718)
34. Estornes Y, Gay F, Gevrey JC, et al: Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells. Int J Cancer 121: 2162-2171, 2007. (Pubitemid 47585594)