Historical control data of neoplastic lesions in the Wistar Hannover Rat among eight 2-year carcinogenicity studies

Experimental and Toxicologic Pathology

Volumn 65, Issue 3, 2013, Pages 243-253

  Carlus, Marine ^a   Elies, Laëtitia ^b   Fouque, Marie Claude ^b   Maliver, Pierre ^b   Schorsch, Frédéric ^b  

^a ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^b BAYER AG   (Germany)

Author keywords

Carcinogenicity studies; Historical control data; Rat; Spontaneous tumors; Survival; Tumor incidence; Wistar

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BREAST ADENOCARCINOMA; BREAST FIBROADENOMA; CANCER INCIDENCE; CANCER LOCALIZATION; CANCER RESEARCH; CARCINOGEN TESTING; CONTROLLED STUDY; ENDOCRINE SYSTEM; ENDOMETRIUM POLYP; FEMALE; FIBROSARCOMA; GENITAL SYSTEM; HISTORICAL RESEARCH; HYPOPHYSIS ADENOMA; IN VIVO STUDY; INTEGUMENTARY SYSTEM; KERATOACANTHOMA; MALE; NONHUMAN; PANCREAS ISLET CELL TUMOR; PHEOCHROMOCYTOMA; RAT; RETROSPECTIVE STUDY; SEX DIFFERENCE; SUBCUTANEOUS FIBROSARCOMA; SUBCUTANEOUS TISSUE TUMOR; THYMOMA; THYROID ADENOMA; TISSUE DISTRIBUTION;

ANIMALS; CARCINOGENICITY TESTS; CONTROL GROUPS; DISEASE SUSCEPTIBILITY; FEMALE; HISTORY, 21ST CENTURY; INCIDENCE; LABORATORY ANIMAL SCIENCE; MALE; NEOPLASMS; RATS; RATS, WISTAR; SEX FACTORS; SURVIVAL ANALYSIS; TIME FACTORS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84872803618     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2011.08.013     Document Type: Article

References (19)

1. Chandra M., Frith C.F. Spontaneous neoplasms in aged control Fischer 344 rats. Cancer Lett 1992, 62:49-56.
2. Eiben R., Bomhard E.M. Trends in mortality, body weights and tumor incidences of Wistar rats over 20 years. Exp Toxicol Pathol 1999, 51:523-536.
3. Festing M.F. Inbred strains should replace outbred stocks in toxicology, safety testing, and drug development. Toxicol Pathol 2010, 38:681-690.
4. Giknis MLA, Clifford CB. Spontaneous neoplasms and survival in Wistar Han Rats: compilation of control group data, 2003, . http://www.criver.com/sitecollectiondocuments/rm_rm_r_survival_wistar_han_rats_compilation_data.pdf.
5. Haseman J.K., Ney E., Nyska A., Rao G.N. Effect of diet and animal care/housing protocols on body weight, survival, tumor incidences, and nephropathy severity of F344 rats in chronic studies. Toxicol Pathol 2003, 31:674-681.
6. Keenan C., Elmore S., Francke-Carroll S., Kemp R., Kerlin R., Peddada S., et al. Best practices for use of historical control data of proliferative rodent lesions. Toxicol Pathol 2009, 37:679-693.
7. Keenan K.P., Ballam G.C., Dixit R., Soper K.A., Laroque P., Mattson B.A., et al. The effects of diet, overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, disease and toxicology. J Nutr 1997, 127:851S-856S.
8. Keenan K.P., Coleman J.B., McCoy C.L., Hoe C.M., Soper K.A., Laroque P. Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth. Toxicol Pathol 2000, 28:788-798.
9. Keenan K.P., Soper K.A., Smith P.F., Ballam G.C., Clark R.L. Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms. Toxicol Pathol 1995, 23:269-286.
10. Kemi M., Keenan K.P., McCoy C., Hoe C.M., Soper K.A., Ballam G.C., et al. The relative protective effects of moderate dietary restriction versus dietary modification on spontaneous cardiomyopathy in male Sprague-Dawley rats. Toxicol Pathol 2000, 28:285-296.
11. OECD. Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies, OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects, OECD Publishing, 2009, [online]. doi:10.1787/9789264071223-en.
12. Official Journal of the European Union. Directive 2010/63/Eu of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes, 2010. http://eur-lex.europa.eu/LexUriServ/LexUriServ.do%3Furi=OJ%3AL%3A2010%3A276%3A0033%3A0079%3AEN%3APDF.
13. Peto R., Pike M.C., Day N.E., Gray R.G., Lee P.N., Parish S., et al. Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. IARC Monogr Eval Carcinog Risk Chem Hum Suppl 1980, 311-426.
14. Poteracki J., Walsh K.M. Spontaneous neoplasms in control Wistar rats: a comparison of reviews. Toxicol Sci 1998, 45:1-8.
15. Renne R., Brix A., Harkema J., Herbert R., Kittel B., Lewis D., et al. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 2009, 37:5S-73S.
16. Tennekes H., Gembardt C., Dammann M., van Ravenzwaay B. The stability of historical control data for common neoplasms in laboratory rats: adrenal gland (medulla), mammary gland, liver, endocrine pancreas, and pituitary gland. Regul Toxicol Pharmacol 2004, 40:18-27.
17. Thoolen B., Maronpot R.R., Harada T., Nyska A., Rousseaux C., Nolte T., et al. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol Pathol 2010, 38:5S-81S.
18. Thurman J.D., Bucci T.J., Hart R.W., Turturro A. Survival, body weight, and spontaneous neoplasms in ad Libitum-fed and food-restricted Fischer-344 rats. Toxicol Pathol 1994, 22:1-9.
19. Walsh K.M., Poteracki J. Spontaneous neoplasms in control Wistar rats. Fundam Appl Toxicol 1994, 22:65-72.