The effects of diet, overfeeding and moderate dietary restriction on sprague-dawley rat survival, disease and toxicology

Journal of Nutrition

Volumn 127, Issue 5 SUPPL., 1997, Pages

  Keenan, Kevin P ^a,b   Ballam, Gordon C ^c   Dixit, Rakesh ^a,b   Soper, Keith A ^a,b   Laroque, Philippe ^a,b   Mattson, Britta A ^a,b   Adams, Stephen P ^a,b   Coleman, John B ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Purina Mills Inc ^*

^c Purina Mills LLC   (United States)

Author keywords

carcinogenicity; dietary restriction; overfeeding; survival; toxicity

Indexed keywords

ANIMAL EXPERIMENT; BODY WEIGHT; BREAST TUMOR; CALORIC INTAKE; CARCINOGENICITY; CARDIOMYOPATHY; CONFERENCE PAPER; DEGENERATIVE DISEASE; DIET; DIET RESTRICTION; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; FOOD INTAKE; HYPOPHYSIS TUMOR; KIDNEY DISEASE; MALE; MORTALITY; NONHUMAN; OVERNUTRITION; RAT; SURVIVAL; TOXICOKINETICS; TUMOR VOLUME;

EID: 0030900112     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.5.851s     Document Type: Conference Paper

References (43)

1. Adams, S. P., Dixit, R., Laws, G. M., Thomas, J., Scares, A., Coleman, J., Soper, K. & Keenan, K. P. (1996) Effect of caloric restriction on oxidative stress biomarkers in liver and kidney of Sprague-Dawley rats. Fund. Appl. Toxicol. 30: 68.
2. Adams, S. P., Laws, G. M., Alberts, D. W., Storer, R. D. & Keenan, K. P. (1995) Tissue levels of 8-hydroxydeoxyguanosine (8-OHdG) in Sprague-Dawley rats fed ad libitum or fed a calorie-restricted diet. Fund. Appl. Toxicol. 15: 279.
3. Albanes, D. (1987) Caloric intake, body weight, and cancer: a review. Nutr. Cancer 9: 199-217.
4. Dixit, R., Keenan, K. P., Patrick, D., Huber, A. C., Robyak, K. & Zacchei, A. (1995) Effects of moderate dietary restriction (MDR) on toxictty and toxicokinetic (TK) profiles of non-genotoxic pharmaceuticals in rats. Fund. Appl. Toxicol. 15: 32.
5. Dixit, R., Keenan, K., Umbenhauer, D., DeLuca, J., Morrissey, R., Coleman, J. & Thomas, J. (1996) Modulation of carcinogenesis bioassay dose selection by moderate dietary restriction (MDR) in rats: relationship with cytochrome P450 (CYP) levels, enzyme activities and toxicokinetics (TK). Fund. Appl. Toxicol. 30: 203.
6. Duffy, P. H., Feuers, R. J., Leakey, J. A., Nakamura, K. D., Turturro, A. & Hart, R. W. (1989) Effect of chronic restriction on physiological variables related to energy metabolism in the male Fischer 344 rat. Mech. Ageing Dev. 48: 117-133.
7. Finch, C. E. (1990) Longevity, Senescence and the Genome. University of Chicago Press, Chicago, IL.
8. Fishbein, L., ed. (1991) Biological Effects of Dietary Restriction. Springer-Verlag, New York, NY.
9. Gumprecht, L. A., Long, C. R., Soper, K. A., Smith, P. F., Hascheck-Hock, W. M. & Keenan, K. P. (1993) The early effects of dietary restriction on the pathogenesis of chronic renal disease in Sprague-Dawley rats at 12 months. Toxicol. Pathol. 21: 528-537.
10. Hart, R. W., Keenan, K. P., Turturro, A., Abdo, K. M., Leakey, J. & Lyn-Cook, L. (1995a) Caloric restriction and toxicology. Fund. Appl. Toxicol. 25: 184-195.
11. Hart, R. W., Neumann, D. A. & Robertson, R. T., eds. (1995b) Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies. ILSI Press, Washington, DC.
12. Haseman, J. K. & Rao, G. R. (1992) Effects of corn-oil, time-related changes and inter-laboratory variability on tumor occurrence in control Fisher 344 (F-344/N) rats. Toxicol. Pathol. 20: 52-60.
13. Iwasaki, K., Gleiser, C. A., Masoro, E. J., McMahan, C. A., Seo, E. J. & Yu, B. P. (1988) The influence of dietary protein source on longevity and age-related disease processes of Fischer rats. J. Gerontol. 43: B5-B12.
14. Keenan, K. P., Smith, P. F., Ballam, G. C., Soper, K. A. & Bokelman, D. L. (1992) The effect of diet and dietary optimization (caloric restriction) on rat survival in carcinogenicity studies-an industrial viewpoint. In: Centre for Medicines Research Workshop. The Carcinogenicity Debate (McAuslane, J.A.N., Lumley, C. F. & Walker, S. R., eds.), pp. 77-102. Butler and Tanner Ltd., London, Great Britain.
15. Keenan, K. P., Smith, P. F., Hertzog, P., Soper, K. A., Ballam, G. G. & Clark, R. L. (1994a) The effects of overfeeding and dietary restriction on Sprague-Dawley rat survival and early pathology biomarkers of aging. Toxicol. Pathol. 22: 300-315.
16. Keenan, K. P., Smith, P. F. & Soper, K. A. (1994b) The effects of dietary (caloric) restriction on rat aging, survival, pathology and toxicology. In: Pathobiology of the Aging Rat, vol. II (Mohr, U., Dungworth, D. L., & Capen, C. C., eds.), pp. 609-628. ILSI Press, Washington, DC.
17. Keenan, K. P. & Soper, K. A. (1995) The effects of ad libitum overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, spontaneous carcinogenesis, chronic disease, and the toxicologic response to pharmaceuticals. In: Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies (Hart, R. W., Neumann, D. A. & Robertson, R., eds.), pp. 99-126. ILSI Press, Washington, DC.
18. Keenan, K. P., Soper, K. A., Hertzog, P. R., Gumprecht, L. A., Smith, P. F., Mattson, B. A., Ballam, G. C. & Clark, R. L. (1995a) Diet, overfeeding and moderate dietary restriction in control Sprague-Dawley rats. II. Effects on age-related proliferative and degenerative lesions. Toxicol. Pathol. 23: 287-302.
19. Keenan, K. P., Soper, K. A., Smith, P. F., Ballam, G. C. & Clark, R. L. (1995b) Diet, overfeeding and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms. Toxicol. Pathol. 23: 269-286.
20. Klurfeld, D. M., Welch, C. B., Davis, M. J. & Kritchevsky, D. (1989) Determination of degree of energy restriction necessary to reduce DMBA-induced mammary tumorigenesis in rats during the promotion phase. J. Nutr. 119: 286-291.
21. Kritchevsky, D. (1993) Energy restriction and carcinogenesis. Food Res. Int. 26: 289-295.
22. Lang, P. L. (1991) Changes in life span of research animals leading to questions about validity of toxicologic studies. Chem. Reg. Rep. 14: 1518-1520.
23. Maeda, H., Gleiser, C. A., Masoro, E. J., Murata, I., McMahan, C. A., Yu, B. P. (1985) Nutritional influences on aging of Fischer 344 rats II. Pathology. J. Gerontol. 40: 671-688.
24. Manson, J. E., Willet, W. C., Stampfer, M. J., et al. (1995) Body weight and mortality among women. N. Eng. J. Med. 333: 677-685.
25. Masoro, E. J., ed. (1995) Aging. In: Handbook of Physiology, sect, 11. Am. Physiol. Soc., Oxford Univ. Press, New York, NY.
26. Masoro, E. J., Iwasaki, K., Gleiser, C. A., McMahan, C. A., Seo, E. J. & Yu, B. P. (1989) Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein. Am. J. Clin, Nutr. 49: 1217-1227.
27. Masoro, E. J., Katz, M. S. & McMahan, C. A. (1989) Evidence for the glycation hypothesis of aging from the food-restricted rodent model. J. Gerontol. 44: B20-B22.
28. Masoro, E. J. & McCarter, R.J.M. (1991) Aging as a consequence of fuel utilization. Aging 3: 117-128.
29. Masoro, E. J., McCarter, R.J.M., Katz, M. S. & McMahan, C. A. (1992) Dietary restriction alters characteristics of glucose fuel use. J. Gerontol. 47: B202-B208.
30. Masoro, E. J., Shimokawa, I. & Yu, B. P. (1991) Retardation of the aging process in rats by food restriction. Ann. N. Y. Acad. Sci. 621: 337-352.
31. McCay, C., Crowell, M. & Maynard, L. (1935) The effect of retarded growth upon the length of the life span and upon the ultimate size. J. Nutr. 10: 63-79.
32. McGinnis, J. M., Foege, W. H. (1993) Actual causes of death in the United States. J. Am. Med. Assoc. 270: 2207-2212.
33. National Research Council, Subcommittee of Laboratory Animal Nutrition (1995) Nutrient Requirements of the Laboratory Rat. In: Nutrient Requirements of Laboratory Animals, 4th rev. ed. pp. 11-79. National Academy Press, Washington, DC.
34. Pollard, M. & Luckert, P. H. (1985) Tumorigenic effects of direct- and indirect-acting chemical carcinogens in rats on a restricted diet. J. Natl. Cancer Inst. 74: 1347-1349.
35. Rao, G. N., Hasemen, J. K., Grumbein, S., Crawford, D. D. & Eustis, S. L. (1990) Growth, body weight, survival, and tumor trends in F-344/N rats during an eleven-year period. Toxicol. Pathol. 18: 61-70.
36. Roe, F.J.C., Lee, P. N., Conybeare, G., Kelly, D., Matter, B., Prentice, D. & Tobin, G. (1995) The Biosure study: influence of composition of diet and food consumption on longevity, degenerative disease and neoplasia in Wistar rats studied for up to 30 months post weaning. Food Chem. Toxicol. 33: 1S-100S.
37. Rogers, A. E., Zeisel, S. H. & Groopman, J. (1993) Diet and carcinogenesis. Carcinogenesis 14: 2205-2217.
38. Rose, M. R. (1991) Evolutionary Biology of Aging. Oxford University Press New York, NY.
39. Ross, M. (1976) Nutrition and longevity in experimental animals. In: Nutrition and Aging (Winick, M., ed.), pp. 23-41. J. Wiley and Sons, New York, NY.
40. Snedecor, G. W. & Cochran, W. G. (1989) Statistical Methods, 8th ed. Iowa State University Press, Ames, IA.
41. Tukey, J. W. (1977) Exploratory Data Analysis. Addison-Wesley, R eading, MA.
42. Weindruch, R. & Walford, R. L. (1988) The Retardation of Aging and Disease by Dietary Restriction. Charles C Thomas, Springfield, IL.
43. Yu, B. P., ed. (1995) Modulation of Aging Processes by Dietary Restriction. CRC Press, Boca Raton, FL.