Slow dissolution behaviour of amorphous capecitabine

International Journal of Pharmaceutics

Volumn 441, Issue 1-2, 2013, Pages 213-217

  Meulenaar, Jelte ^a,c   Beijnen, Jos H ^a,b   Schellens, Jan H M ^b,c   Nuijen, Bastiaan ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Amorphous; Capecitabine; Dissolution; Recrystallization; Slow release; Spray drying

Indexed keywords

CAPECITABINE;

ARTICLE; DRUG SOLUBILITY; GLASS TRANSITION TEMPERATURE; PRIORITY JOURNAL; SUSTAINED RELEASE FORMULATION; TABLET COMPRESSION; TABLET DISINTEGRATION; TABLET FORMULATION; WATER CONTENT;

ANTIMETABOLITES, ANTINEOPLASTIC; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DEOXYCYTIDINE; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; FEASIBILITY STUDIES; FLUOROURACIL; GELS; REPRODUCIBILITY OF RESULTS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRANSITION TEMPERATURE;

EID: 84872803265     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.11.041     Document Type: Article

References (14)

1. M. Aulton Pharmaceutics, the Science of Dosage from Design second ed. 2002 Churchill Livingstone Edinburgh
2. A.M. Kaushal, P. Gupta, and A.K. Bansal Amorphous drug delivery systems: molecular aspects, design, and performance Crit. Rev. Ther. Drug Carrier Syst. 21 2004 133 193
3. Z.A. Langham, J. Booth, L.P. Hughes, G.K. Reynolds, and S.A.C. Wren Mechanistic insights into the dissolution of spray-dried amorphous solid dispersions J. Pharm. Sci. 101 2012 2798 2810
4. C. Leuner, and J. Dressman Improving drug solubility for oral delivery using solid dispersions Eur. J. Pharm. Biopharm. 50 2000 47 60
5. M.R.C Marques, and F. Mao USP34-NF29 2011 p. 2148
6. Meta-analysis Group In Cancer Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer J. Clin. Oncol. 16 1998 301 308
7. J.J. Moes, S.L.W. Koolen, A.D.R. Huitema, J.H.M. Schellens, J.H. Beijnen, and B. Nuijen Pharmaceutical development and preliminary clinical testing of an oral solid dispersion formulation of docetaxel (ModraDoc001) Int. J. Pharm. 420 2011 244 250
8. G. Pentheroudakis, and C. Twelves Capecitabine (Xeloda): from the laboratory to the patient's home Clin. Colorectal Cancer 2 2002 16 23
9. ® Summary of Product Characteristics 2006 Nutley NJ
10. J.H. Schellens Capecitabine Oncologist 12 2007 152 155
11. T. Sebhatu, and G. Alderborn Relationships between the effective interparticulate contact area and the tensile strength of tablets of amorphous and crystalline lactose of varying particle size Eur. J. Pharm. Sci. 8 1999 235 242
12. K. Van der Voort Maarschalk, K. Zuurman, H. Vromans, G.K. Bolhuis, and C.F. Lerk Stress relaxation of compacts produced from viscoelastic materials Int. J. Pharm. 151 1997 27 34
13. D.J. Van Drooge, W.L.J. Hinrichs, and H.W. Frijlink Anomalous dissolution behaviour of tablets prepared from sugar glass-based solid dispersions J. Control. Release 97 2004 441 452
14. C.M. Walko, and C. Lindley Capecitabine: a review Clin. Ther. 27 2005 23 44