Structural Basis of the γ-Lactone-Ring Formation in Ascorbic Acid Biosynthesis by the Senescence Marker Protein-30/Gluconolactonase

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Aizawa, Shingo ^a,b,c   Senda, Miki ^d   Harada, Ayaka ^c,e   Maruyama, Naoki ^b   Ishida, Tetsuo ^f   Aigaki, Toshiro ^a   Ishigami, Akihito ^b   Senda, Toshiya ^c  

^a TOKYO METROPOLITAN UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d Koto ku   (Japan)

^e TOKYO DENKI UNIVERSITY   (Japan)

^f SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 ANHYDROSORBITOL; ASCORBIC ACID; DIVALENT CATION; GAMMA LACTONE DERIVATIVE; GLUCONOLACTONASE; GLUCOSE; HYDROXYL GROUP; METAL ION; MONOSACCHARIDE; REGUCALCIN; XYLITOL;

ANIMAL CELL; ARTICLE; ASCORBIC ACID BIOSYNTHESIS; BINDING KINETICS; BIOSYNTHESIS; COMPARATIVE STUDY; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLARIZATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; VITAMIN METABOLISM;

ANIMALS; ASCORBIC ACID; CALCIUM-BINDING PROTEINS; CARBOXYLIC ESTER HYDROLASES; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; GLUCOSE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTONES; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; XYLITOL;

EID: 84872797439     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053706     Document Type: Article

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